Výsledky vyhledávání - "Elias Utreras"

Protocols for Characterization of Cdk5 Kinase Activity

Autor: Elias Utreras, Ashok B. Kulkarni, Harish C. Pant, B K Binukumar, Niranjana D. Amin, Bradford Hall, Anita Terse, Manju Bhaskar, Tej K. Pareek

Publikováno v: Curr Protoc

Cyclin-dependent kinases (Cdks) are generally known to be involved in controlling the cell cycle, but Cdk5 is a unique member of this protein family for being most active in post-mitotic neurons. Cdk5 is developmentally important in regulating neuron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971908650dde0dfc19b94958b3a2ea0b
https://doi.org/10.1002/cpz1.276

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Akademický článek

Role of PPARγ in the Differentiation and Function of Neurons

Autor: Rodrigo A. Quintanilla, Elias Utreras, Fabián A. Cabezas-Opazo

Publikováno v: PPAR Research, Vol 2014 (2014)

Neuronal processes (neurites and axons) have an important role in brain cells communication and, generally, they are damaged in neurodegenerative diseases. Recent evidence has showed that the activation of PPARγ pathway promoted neuronal differentia

Externí odkaz: https://doaj.org/article/d0b2cca2314b4726879608d3861cfe06

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Akademický článek

Regulation of Sox6 by cyclin dependent kinase 5 in brain.

Autor: Parvathi Rudrabhatla, Elias Utreras, Howard Jaffe, Ashok B Kulkarni

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e89310 (2014)

Cyclin dependent kinase 5 (Cdk5) is a proline-directed Ser/Thr kinase involved in various biological functions during normal brain development and neurodegeneration. In brain, Cdk5 activity is specific to post-mitotic neurons, due to neuronal specifi

Externí odkaz: https://doaj.org/article/eb637fbef23a470a8267bc8c48899d01

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Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372

Autor: Rodrigo Sandoval, Bradford Hall, Elias Utreras, Patricio A. Castro, Stanko S. Stojilkovic, Ashok B. Kulkarni, Christian Gonzalez-Billault, Anita Terse, Milos B. Rokic, Pablo Lazcano, Claudio Coddou, María José Hevia

Publikováno v: Pain
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

The purinergic P2X2 receptor (P2X2R) is an adenosine triphosphate-gated ion channel widely expressed in the nervous system. Here, we identified a putative cyclin-dependent kinase 5 (Cdk5) phosphorylation site in the full-size variant P2X2aR (TPKH), w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fb12dc4fe5e866389b17b689281aae
https://doi.org/10.1097/j.pain.0000000000001021

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Targeted overexpression of tumor necrosis factor-α increases cyclin-dependent kinase 5 activity and TRPV1-dependent Ca2+ influx in trigeminal neurons

Autor: Ricardo Piña, Pablo Rozas, Ashok B. Kulkarni, Rodolfo Madrid, Christian Gonzalez-Billault, María Pertusa, Andrew Cho, Pablo Lazcano, Elias Utreras, Anita Terse

Publikováno v: Pain
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

We reported earlier that TNF-α, a proinflammatory cytokine implicated in many inflammatory disorders causing orofacial pain, increases the activity of Cdk5, a key kinase involved in brain development and function and recently found to be involved in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172fd9bee8bb523223d7d668794c78e4
https://doi.org/10.1097/j.pain.0000000000000527

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Behavioral and synaptic alterations relevant to obsessive-compulsive disorder in mice with increased EAAT3 expression

Autor: Elias Utreras, Andrés E. Chávez, Anna K. Radke, Andrew Cho, Angélica P. Escobar, Ayesha Sengupta, Ashok B. Kulkarni, Sebastián F. Estay, Jens R. Wendland, Dennis L. Murphy, Pablo R. Moya, Andrew Holmes, Francisca Henríquez-Belmar, Ramón Sotomayor-Zárate, Valentina Haro-Acuña, Claudia Delgado-Acevedo, Cristopher A. Reyes

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 44(6)

Obsessive-compulsive disorder (OCD) is a severe, chronic neuropsychiatric disorder with a strong genetic component. The SLC1A1 gene encoding the neuronal glutamate transporter EAAT3 has been proposed as a candidate gene for this disorder. Gene varian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59915e8abf15d055489ddd885fe971d8
https://pubmed.ncbi.nlm.nih.gov/30787427

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Cdk5 regulates Rap1 activity

Autor: Alejandro Maass, Cristina Olmos, Elias Utreras, Alex Di Genova, Christian Gonzalez-Billault, Ashok B. Kulkarni, Erick Contreras-Vallejos, Daniel R. Henríquez

Publikováno v: NEUROCHEMISTRY INTERNATIONAL
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Metabolomics
Neurochemistry International

Rap1 signaling is important for migration, differentiation, axonal growth, and during neuronal polarity. Rap1 can be activated by external stimuli, which in turn regulates specific guanine nucleotide exchange factors such as C3G, among others. Cdk5 f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3afd0aa964d49406e066cd4c604cbb
https://doi.org/10.1016/j.neuint.2013.02.011

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Inhibition of cyclin-dependent kinase 5 but not of glycogen synthase kinase 3-β prevents neurite retraction and tau hyperphosphorylation caused by secretable products of human T-cell leukemia virus type I-infected lymphocytes

Autor: Luis Cartier, Elias Utreras, L. Collados, Javier Puente, Horacio Maldonado, A.M. Kettlun, Ashok B. Kulkarni, Mario Chiong, María Elsa Pando, M.A. Valenzuela, Eugenio Ramírez

Publikováno v: JOURNAL OF NEUROSCIENCE RESEARCH
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

Human T-cell leukemia virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurodegenerative disease characterized by selective loss of axons and myelin in the corticospinal tracts. This central axonopathy may origi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9062f1de1ba027769267f2960e5ff72c
https://doi.org/10.1002/jnr.22678

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Tumor Necrosis Factor-α Regulates Cyclin-dependent Kinase 5 Activity during Pain Signaling through Transcriptional Activation of p35

Autor: Michael J. Iadarola, Ashok B. Kulkarni, Parvathi Rudrabhatla, Harish C. Pant, Akira Futatsugi, Elias Utreras, Jason M. Keller

Publikováno v: Journal of Biological Chemistry. 284:2275-2284

Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase. We have previously reported that Cdk5 participates in the regulation of nociceptive signaling, and the expression of Cdk5 and its activator, p35, are up-regulated in noci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab0a6c94fd8ce14bcbb958641437969
https://doi.org/10.1074/jbc.m805052200

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Prenatal stress down-regulates Reelin expression by methylation of its promoter and induces adult behavioral impairments in rats

Autor: Juan F. Montiel, Martin Montecino, Ismael Palacios-García, Gabriela Díaz-Véliz, Elias Utreras, Ariel Lara-Vasquez, Hugo Sepulveda, Christian Gonzalez-Billault, Francisco Aboitiz

Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0117680 (2015)
Plos One
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
PLoS ONE

Prenatal stress causes predisposition to cognitive and emotional disturbances and is a risk factor towards the development of neuropsychiatric conditions like depression, bipolar disorders and schizophrenia. The extracellular protein Reelin, expresse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65001c5a4f14b9024d88e7629e47512c
https://doaj.org/article/036d7b30e48844bb9786c8828dd0ba44

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