Výsledky vyhledávání - "Elias T. Zambidis"

Akademický článek

Antiviral cellular therapy for enhancing T-cell reconstitution before or after hematopoietic stem cell transplantation (ACES): a two-arm, open label phase II interventional trial of pediatric patients with risk factor assessment

Autor: Michael D. Keller, Patrick J. Hanley, Yueh-Yun Chi, Paibel Aguayo-Hiraldo, Christopher C. Dvorak, Michael R. Verneris, Donald B. Kohn, Sung-Yun Pai, Blachy J. Dávila Saldaña, Benjamin Hanisch, Troy C. Quigg, Roberta H. Adams, Ann Dahlberg, Shanmuganathan Chandrakasan, Hasibul Hasan, Jemily Malvar, Mariah A. Jensen-Wachspress, Christopher A. Lazarski, Gelina Sani, John M. Idso, Haili Lang, Pamela Chansky, Chase D. McCann, Jay Tanna, Allistair A. Abraham, Jennifer L. Webb, Abeer Shibli, Amy K. Keating, Prakash Satwani, Pawel Muranski, Erin Hall, Michael J. Eckrich, Evan Shereck, Holly Miller, Ewelina Mamcarz, Rajni Agarwal, Satiro N. De Oliveira, Mark T. Vander Lugt, Christen L. Ebens, Victor M. Aquino, Jeffrey J. Bednarski, Julia Chu, Suhag Parikh, Jennifer Whangbo, Michail Lionakis, Elias T. Zambidis, Elizabeth Gourdine, Catherine M. Bollard, Michael A. Pulsipher

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Viral infections remain a major risk in immunocompromised pediatric patients, and virus-specific T cell (VST) therapy has been successful for treatment of refractory viral infections in prior studies. We performed a phase II multicenter stud

Externí odkaz: https://doaj.org/article/fcdca2f7424c452f994b7e545a14509b

Zobrazit plný text záznamu

Akademický článek

Harnessing bioengineered myeloid progenitors for precision immunotherapies

Autor: Willem Buys, Elias T. Zambidis

Publikováno v: npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-9 (2023)

Abstract Granulocytes and macrophages are the frontline defenders of the innate immune system. These myeloid cells play a crucial role in not only eliminating pathogens and tumor cells, but also regulating adaptive immune responses. In neonatal sepsi

Externí odkaz: https://doaj.org/article/6477ca56a9534a60be590f701bfb0bba

Zobrazit plný text záznamu

Akademický článek

Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of rapamycin complex 1

Autor: Manasa P. Srikanth, Jace W. Jones, Maureen Kane, Ola Awad, Tea Soon Park, Elias T. Zambidis, Ricardo A. Feldman

Publikováno v: Stem Cells Translational Medicine, Vol 10, Iss 7, Pp 1081-1094 (2021)

Abstract Gaucher disease (GD) is a lysosomal storage disorder caused by mutations in GBA1, the gene that encodes lysosomal β‐glucocerebrosidase (GCase). Mild mutations in GBA1 cause type 1 non‐neuronopathic GD, whereas severe mutations cause typ

Externí odkaz: https://doaj.org/article/28529c8f68eb46f1a11a4250551275b4

Zobrazit plný text záznamu

Akademický článek

Running the full human developmental clock in interspecies chimeras using alternative human stem cells with expanded embryonic potential

Autor: Justin Thomas, Ludovic Zimmerlin, Jeffrey S. Huo, Michael Considine, Leslie Cope, Elias T. Zambidis

Publikováno v: npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-13 (2021)

Abstract Human pluripotent stem cells (hPSCs) can generate specialized cell lineages that have great potential for regenerative therapies and disease modeling. However, the developmental stage of the lineages generated from conventional hPSC cultures

Externí odkaz: https://doaj.org/article/2d63db817ceb45c390898d2afa8999ce

Zobrazit plný text záznamu

Akademický článek

Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina

Autor: Tea Soon Park, Ludovic Zimmerlin, Rebecca Evans-Moses, Justin Thomas, Jeffrey S. Huo, Riya Kanherkar, Alice He, Nensi Ruzgar, Rhonda Grebe, Imran Bhutto, Michael Barbato, Michael A. Koldobskiy, Gerard Lutty, Elias T. Zambidis

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)

hPSCs in culture acquire a more naïve pluripotent state upon tankyrase inhibition. Here, the authors show that tankyrase inhibitor-regulated naïve hiPSCs from diabetic donors generate more vascular progenitors and more efficient engraftment into mo

Externí odkaz: https://doaj.org/article/4cd3936d370a4ba1b02244ee053db93b

Zobrazit plný text záznamu

Akademický článek

Altered Differentiation Potential of Gaucherâs Disease iPSC Neuronal Progenitors due to Wnt/Î²-Catenin Downregulation

Autor: Ola Awad, Leelamma M. Panicker, Rania M. Deranieh, Manasa P. Srikanth, Robert A. Brown, Antanina Voit, Tejasvi Peesay, Tea Soon Park, Elias T. Zambidis, Ricardo A. Feldman

Publikováno v: Stem Cell Reports, Vol 9, Iss 6, Pp 1853-1867 (2017)

Summary: Gaucherâs disease (GD) is an autosomal recessive disorder caused by mutations in the GBA1 gene, which encodes acid Î²-glucocerebrosidase (GCase). Severe GBA1 mutations cause neuropathology that manifests soon after birth, suggesting that

Externí odkaz: https://doaj.org/article/b566094708174a4a9b8d13faa014a0f1

Zobrazit plný text záznamu

Akademický článek

High-Fidelity Reprogrammed Human IPSCs Have a High Efficacy of DNA Repair and Resemble hESCs in Their MYC Transcriptional Signature

Autor: Pratik K. Nagaria, Carine Robert, Tea Soon Park, Jeffrey S. Huo, Elias T. Zambidis, Feyruz V. Rassool

Publikováno v: Stem Cells International, Vol 2016 (2016)

Human induced pluripotent stem cells (hiPSCs) are reprogrammed from adult or progenitor somatic cells and must make substantial adaptations to ensure genomic stability in order to become “embryonic stem cell- (ESC-) like.” The DNA damage response

Externí odkaz: https://doaj.org/article/c05782e9dba145c5951f7f3bf252c8cd

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání