Výsledky vyhledávání - "Elias T Zambidis"

Akademický článek

Antiviral cellular therapy for enhancing T-cell reconstitution before or after hematopoietic stem cell transplantation (ACES): a two-arm, open label phase II interventional trial of pediatric patients with risk factor assessment

Autor: Michael D. Keller, Patrick J. Hanley, Yueh-Yun Chi, Paibel Aguayo-Hiraldo, Christopher C. Dvorak, Michael R. Verneris, Donald B. Kohn, Sung-Yun Pai, Blachy J. Dávila Saldaña, Benjamin Hanisch, Troy C. Quigg, Roberta H. Adams, Ann Dahlberg, Shanmuganathan Chandrakasan, Hasibul Hasan, Jemily Malvar, Mariah A. Jensen-Wachspress, Christopher A. Lazarski, Gelina Sani, John M. Idso, Haili Lang, Pamela Chansky, Chase D. McCann, Jay Tanna, Allistair A. Abraham, Jennifer L. Webb, Abeer Shibli, Amy K. Keating, Prakash Satwani, Pawel Muranski, Erin Hall, Michael J. Eckrich, Evan Shereck, Holly Miller, Ewelina Mamcarz, Rajni Agarwal, Satiro N. De Oliveira, Mark T. Vander Lugt, Christen L. Ebens, Victor M. Aquino, Jeffrey J. Bednarski, Julia Chu, Suhag Parikh, Jennifer Whangbo, Michail Lionakis, Elias T. Zambidis, Elizabeth Gourdine, Catherine M. Bollard, Michael A. Pulsipher

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Viral infections remain a major risk in immunocompromised pediatric patients, and virus-specific T cell (VST) therapy has been successful for treatment of refractory viral infections in prior studies. We performed a phase II multicenter stud

Externí odkaz: https://doaj.org/article/fcdca2f7424c452f994b7e545a14509b

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Akademický článek

Growth factor-activated stem cell circuits and stromal signals cooperatively accelerate non-integrated iPSC reprogramming of human myeloid progenitors.

Autor: Tea Soon Park, Jeffrey S Huo, Ann Peters, C Conover Talbot, Karan Verma, Ludovic Zimmerlin, Ian M Kaplan, Elias T Zambidis

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e42838 (2012)

Nonviral conversion of skin or blood cells into clinically useful human induced pluripotent stem cells (hiPSC) occurs in only rare fractions (~0.001%-0.5%) of donor cells transfected with non-integrating reprogramming factors. Pluripotency induction

Externí odkaz: https://doaj.org/article/bb295cefd4024c0da87cf3df9bb3a84c

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Akademický článek

A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability.

Autor: Paul W Burridge, Susan Thompson, Michal A Millrod, Seth Weinberg, Xuan Yuan, Ann Peters, Vasiliki Mahairaki, Vassilis E Koliatsos, Leslie Tung, Elias T Zambidis

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e18293 (2011)

The production of cardiomyocytes from human induced pluripotent stem cells (hiPSC) holds great promise for patient-specific cardiotoxicity drug testing, disease modeling, and cardiac regeneration. However, existing protocols for the differentiation o

Externí odkaz: https://doaj.org/article/c68c721930e24e289ccb28097a812e54

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Akademický článek

Harnessing bioengineered myeloid progenitors for precision immunotherapies

Autor: Willem Buys, Elias T. Zambidis

Publikováno v: npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-9 (2023)

Abstract Granulocytes and macrophages are the frontline defenders of the innate immune system. These myeloid cells play a crucial role in not only eliminating pathogens and tumor cells, but also regulating adaptive immune responses. In neonatal sepsi

Externí odkaz: https://doaj.org/article/6477ca56a9534a60be590f701bfb0bba

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Akademický článek

Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of rapamycin complex 1

Autor: Manasa P. Srikanth, Jace W. Jones, Maureen Kane, Ola Awad, Tea Soon Park, Elias T. Zambidis, Ricardo A. Feldman

Publikováno v: Stem Cells Translational Medicine, Vol 10, Iss 7, Pp 1081-1094 (2021)

Abstract Gaucher disease (GD) is a lysosomal storage disorder caused by mutations in GBA1, the gene that encodes lysosomal β‐glucocerebrosidase (GCase). Mild mutations in GBA1 cause type 1 non‐neuronopathic GD, whereas severe mutations cause typ

Externí odkaz: https://doaj.org/article/28529c8f68eb46f1a11a4250551275b4

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Akademický článek

Running the full human developmental clock in interspecies chimeras using alternative human stem cells with expanded embryonic potential

Autor: Justin Thomas, Ludovic Zimmerlin, Jeffrey S. Huo, Michael Considine, Leslie Cope, Elias T. Zambidis

Publikováno v: npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-13 (2021)

Abstract Human pluripotent stem cells (hPSCs) can generate specialized cell lineages that have great potential for regenerative therapies and disease modeling. However, the developmental stage of the lineages generated from conventional hPSC cultures

Externí odkaz: https://doaj.org/article/2d63db817ceb45c390898d2afa8999ce

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Akademický článek

Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina

Autor: Tea Soon Park, Ludovic Zimmerlin, Rebecca Evans-Moses, Justin Thomas, Jeffrey S. Huo, Riya Kanherkar, Alice He, Nensi Ruzgar, Rhonda Grebe, Imran Bhutto, Michael Barbato, Michael A. Koldobskiy, Gerard Lutty, Elias T. Zambidis

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)

hPSCs in culture acquire a more naïve pluripotent state upon tankyrase inhibition. Here, the authors show that tankyrase inhibitor-regulated naïve hiPSCs from diabetic donors generate more vascular progenitors and more efficient engraftment into mo

Externí odkaz: https://doaj.org/article/4cd3936d370a4ba1b02244ee053db93b

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Akademický článek

Altered Differentiation Potential of Gaucherâs Disease iPSC Neuronal Progenitors due to Wnt/Î²-Catenin Downregulation

Autor: Ola Awad, Leelamma M. Panicker, Rania M. Deranieh, Manasa P. Srikanth, Robert A. Brown, Antanina Voit, Tejasvi Peesay, Tea Soon Park, Elias T. Zambidis, Ricardo A. Feldman

Publikováno v: Stem Cell Reports, Vol 9, Iss 6, Pp 1853-1867 (2017)

Summary: Gaucherâs disease (GD) is an autosomal recessive disorder caused by mutations in the GBA1 gene, which encodes acid Î²-glucocerebrosidase (GCase). Severe GBA1 mutations cause neuropathology that manifests soon after birth, suggesting that

Externí odkaz: https://doaj.org/article/b566094708174a4a9b8d13faa014a0f1

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