Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids

Autor: Giovanna Delogu, Lourdes Santana, Carmen Picciau, Gianni Podda, Elias Quezada q, Maria Joao Matos, M. Benedetta Fadda, Benedetta Era, Marcella Corda, Antonella Fais

Publikováno v: Molecules, Vol 14, Iss 7, Pp 2514-2520 (2009)

In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 values of these compounds wer

Externí odkaz: https://doaj.org/article/e1c0af23f9fd42a78d2c9b79ffdeba15

GC/MSn analysis of the crude reaction mixtures from Friedel–Crafts acylation: Unambiguous identification and differentiation of 3-aroylbenzofurans from their 4- and 6-regioisomers

Autor: Giovanna Delogu, Michela Begala, Michele Mancinelli, Elias Quezada

Publikováno v: Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname
Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela
Universidad de Santiago de Compostela (USC)

Rationale: 3-Aroylbenzofurans and their 2-nitrophenyl derivatives constitute fundamental intermediates for the synthesis of target compounds with pharmaceutical properties. However, their preparation via the Friedel–Crafts acylation of 2-phenylbenz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19fd8d925ff64a6934de6884ce3d4d49
https://hdl.handle.net/10347/26233

Novel coumarin-pyridazine hybrids as selective MAO-B inhibitors for the Parkinson’s disease therapy

Autor: Mattia Sturlese, Pedro Besada, Elias Quezada, Miguel Alonso-Pena, Stefano Moro, Carmen Terán, Dolores Viña, María Carmen Costas-Lago, Fernanda Rodríguez-Enríquez, José Angel Fontenla, Iria Torres-Terán

The 3-pyridazinylcoumarin scaffold was previously reported as an efficient core for the discovery of reversible and selective inhibitors of MAO-B, a validated drug target for PD therapy which also plays an important role in the AD progress. Looking f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156b018afc28f64a976fb7e7a10bc968
http://hdl.handle.net/11577/3349054

Discovery of new phthalazinones as vasodilator agents and novel pharmacological tools to study calcium channels

Autor: José Gil-Longo, Dolores Viña, Javier Munín, Giovanna Delogu, Eugenio Uriarte, Elias Quezada

Publikováno v: Future medicinal chemistry.

Aim: Hydralazine has led to the synthesis of phthalazinone derivatives which induce vasorelaxation. Methods: A new series of 2-(aminoalkyl)-4-benzyl-2H-phthalazin-1-one derivatives has been synthesized to study their vasorelaxant activity. Results: A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d460b9d65a2c6a2da6557328d3390b
https://pubmed.ncbi.nlm.nih.gov/30801201

MAO Inhibitory Activity of 2-Arylbenzofurans versus 3-Arylcoumarins: Synthesis, in vitro Study, and Docking Calculations

Autor: Nicholas P. Tatonetti, Dolores Viña, Santiago Vilar, Elias Quezada, Maria João Matos, Lourdes Santana, Giovanna Delogu, Carmen Picciau, Matilde Yáñez, Eugenio Uriarte, Giulio Ferino, Silvia Serra, Enzo Cadoni

Publikováno v: ChemMedChem. 8:956-966

Monoamine oxidase (MAO) is an important drug target for the treatment of neurological disorders. Several 3-arylcoumarin derivatives were previously described as interesting selective MAO-B inhibitors. Preserving the trans-stilbene structure, a series

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c093f540217d07def29ab0b74b9b2393
https://doi.org/10.1002/cmdc.201300048