Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Elias P. Rosen"'
Autor:
Jennifer Ocasio, Benjamin Babcock, Daniel Malawsky, Seth J. Weir, Lipin Loo, Jeremy M. Simon, Mark J. Zylka, Duhyeong Hwang, Taylor Dismuke, Marina Sokolsky, Elias P. Rosen, Rajeev Vibhakar, Jiao Zhang, Olivier Saulnier, Maria Vladoiu, Ibrahim El-Hamamy, Lincoln D. Stein, Michael D. Taylor, Kyle S. Smith, Paul A. Northcott, Alejandro Colaneri, Kirk Wilhelmsen, Timothy R. Gershon
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Although the hedgehog (HH) pathway is known to be deregulated in medulloblastoma, inhibitors of the pathway have shown disappointing clinical benefit. Using single-cell sequencing in a mouse model of the disease, the authors show that the response to
Externí odkaz:
https://doaj.org/article/2fac3f5447844cbea3e21cfcf9b5423c
Autor:
Jennifer Karin Ocasio, Benjamin Babcock, Daniel Malawsky, Seth J. Weir, Lipin Loo, Jeremy M. Simon, Mark J. Zylka, Duhyeong Hwang, Taylor Dismuke, Marina Sokolsky, Elias P. Rosen, Rajeev Vibhakar, Jiao Zhang, Olivier Saulnier, Maria Vladoiu, Ibrahim El-Hamamy, Lincoln D. Stein, Michael D. Taylor, Kyle S. Smith, Paul A. Northcott, Alejandro Colaneri, Kirk Wilhelmsen, Timothy R. Gershon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/c9c57a0e4ea24207a669b99052c30e34
Autor:
Aaron S. Devanathan, Julie B. Dumond, Daijha J.C. Anderson, Kristen Moody, Amanda J. Poliseno, Amanda P. Schauer, Craig Sykes, Cynthia L. Gay, Elias P. Rosen, Angela D.M. Kashuba, Mackenzie L. Cottrell
Publikováno v:
Clinical Pharmacology & Therapeutics. 113:896-903
Tenofovir diphosphate (TFVdp; an active metabolite of oral HIV pre-exposure prophylaxis [PrEP]) is measured in dried blood spots (DBS) to estimate adherence. However, TFVdp's long half-life in whole blood may lead to misclassification following a rec
Autor:
Elias P. Rosen, Nicole White, William M. Gilliland, Roy R. Gerona, Monica Gandhi, K. Rivet Amico, Kenneth H. Mayer, Roy M. Gulick, Angela DM Kashuba
Objective measures of adherence for antiretrovirals used as pre-exposure prophylaxis (PrEP) are critical for improving preventative efficacy in both clinical trials and real-world application. Current objective adherence measures either reflect only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e724c956fab54642a07711d1c95d4c9
https://doi.org/10.1101/2023.01.30.526384
https://doi.org/10.1101/2023.01.30.526384
Autor:
Aaron S. Devanathan, Nicole R. White, Yury Desyaterik, Gabriela De la Cruz, Michael Nekorchuk, Margaret Terry, Kathleen Busman-Sahay, Lourdes Adamson, Paul Luciw, Yuri Fedoriw, Jacob D. Estes, Elias P. Rosen, Angela D. M. Kashuba
Publikováno v:
Antimicrob Agents Chemother
Although current antiretroviral therapy (ART) has increased life expectancy, a cure for human immunodeficiency virus (HIV) remains elusive due to the persistence of the virus in tissue reservoirs. In the present study, we sought to elucidate the rela
Autor:
Elias P, Rosen, Claire, Deleage, Nicole, White, Craig, Sykes, Catherine, Brands, Lourdes, Adamson, Paul, Luciw, Jacob D, Estes, Angela D M, Kashuba
Publikováno v:
Journal of the International AIDS Society. 25
HIV reservoirs and infected cells may persist in tissues with low concentrations of antiretrovirals (ARVs). Traditional pharmacology methods cannot assess variability in ARV concentrations within morphologically complex tissues, such as lymph nodes (
Autor:
Joseph N. Mwangi, William M. Gilliland, Nicole White, Craig Sykes, Amanda Poliseno, Kelly A. Knudtson, Lisa Hightow-Weidman, Angela D. M. Kashuba, Elias P. Rosen
Publikováno v:
Antimicrob Agents Chemother
Most measures of adherence to antiretroviral therapy require a blood sample, and none capture longitudinal daily adherence. A new noninvasive method for measuring daily adherence to antiretroviral regimens containing emtricitabine (FTC) was developed
Autor:
Angela D. M. Kashuba, William M Gilliland, Elias P. Rosen, Heather M.A. Prince, Ann Marie Weideman, Nicole White, Bryan H Yam, Joseph N. Mwangi
Publikováno v:
Analyst
Analysis of drugs in hair by mass spectrometry imaging (MSI) has great potential as an objective, long-term measure of medication adherence. However, the fidelity of the chemical record in hair may be compromised by any cosmetic hair treatments. Here
Autor:
Michael D. Taylor, Marina Sokolsky, Daniel S Malawsky, Benjamin Babcock, Duhyeong Hwang, Elias P. Rosen, Jiao Zhang, Jeremy M. Simon, Lipin Loo, Ibrahim El-Hamamy, Jennifer Ocasio, Kyle S. Smith, Rajeev Vibhakar, Mark J. Zylka, Maria C. Vladoiu, Timothy R. Gershon, Olivier Saulnier, Seth J. Weir, Taylor Dismuke, Kirk C. Wilhelmsen, Alejandro Colaneri, Paul A. Northcott, Lincoln Stein
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Targeting oncogenic pathways holds promise for brain tumor treatment, but inhibition of Sonic Hedgehog (SHH) signaling has failed in SHH-driven medulloblastoma. Cellular diversity within tumors and reduced lineage commitment can undermine targeted th
Autor:
Heather M.A. Prince, Elias P. Rosen, Amanda Poliseno, William M. Gilliland, Angela D. M. Kashuba
Publikováno v:
Anal Chem
Here, we assess infrared matrix assisted laser desorption electrospray ionization (IR-MALDESI) mass spectrometry imaging (MSI) analysis of hair as a clinical tool for monitoring patient adherence to the antiretroviral maraviroc (MVC). A custom MATLAB