Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Elias N. Glaros"'
Autor:
Theresa N. T. Dang, Carol Dobson-Stone, Elias N. Glaros, Woojin S. Kim, Marianne Hallupp, Lauren Bartley, Olivier Piguet, John R. Hodges, Glenda M. Halliday, Kay L. Double, Peter R. Schofield, Peter J. Crouch, John B. J. Kwok
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 5, Pp 1198-1204 (2013)
SUMMARY Frontotemporal dementia (FTD) is associated with motor neurone disease (FTD-MND), corticobasal syndrome (CBS) and progressive supranuclear palsy syndrome (PSPS). Together, this group of disorders constitutes a major cause of young-onset demen
Externí odkaz:
https://doaj.org/article/652819affd724e67a4c39f977e1db999
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 8, Pp 1677-1681 (2008)
Glycosphingolipids (GSLs) have been implicated as potential atherogenic lipids. Studies in apolipoprotein E-null (apoE−/−) mice indicate that exacerbated tissue GSL accumulation resulting from α-galactosidase deficiency promotes atherosclerosis,
Externí odkaz:
https://doaj.org/article/d8f8969a879c40109a1e7508fe6527b8
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 2, Pp 324-331 (2008)
The serine palmitoyl transferase inhibitor myriocin potently suppresses the development of atherosclerosis in apolipoprotein E (apoE) gene knockout (apoE−/−) mice fed a high-fat diet. This is associated with reduced plasma sphingomyelin (SM) and
Externí odkaz:
https://doaj.org/article/09a3d02ea6314eb9a104de9b2f8d1ac6
Autor:
Yizhou Huang, Karen L. MacKenzie, Dominik Beck, Santi Suryani, John E. Pimanda, Vashe Chandrakanthan, Jake Olivier, Adam Boulton, Elias N. Glaros, Richard B. Lock, John H. Bushweller, Julie A. I. Thoms, Shane R. Thomas, Kathy Knezevic, Melinda L. Tursky, Jason W. H. Wong
Publikováno v:
Leukemia. 30:1552-1561
Aberrant ERG (v-ets avian erythroblastosis virus E26 oncogene homolog) expression drives leukemic transformation in mice and high expression is associated with poor patient outcomes in acute myeloid leukemia (AML) and T-acute lymphoblastic leukemia (
Autor:
Leonardo Pasalic, Latasha Abeynaike, Heather Campbell, Elias N. Glaros, Philip J. Hogg, Vu Minh Hua, Vivien M. Chen
Publikováno v:
Blood. 126:2852-2862
A subpopulation of platelets fulfills a procoagulant role in hemostasis and thrombosis by enabling the thrombin burst required for fibrin formation and clot stability at the site of vascular injury. Excess procoagulant activity is linked with patholo
Publikováno v:
Proceedings of the National Academy of Sciences. 111:8119-8124
Oxidative stress (an overproduction of reactive oxygen species in relation to defense mechanisms) may restrict investment in life history traits, such as growth, reproduction, lifespan, and the production of sexual signals to attract mates. The const
Autor:
Anthony S. Don, Surabhi Bhatia, Elias N. Glaros, Woojin S. Kim, Shuichi Tsuruoka, Glenda M. Halliday, Cynthia Shannon Weickert, Jen-Hsiang T. Hsiao
Publikováno v:
Biochemical Journal. 452:401-410
Members of the ABCA (ATP-binding cassette subfamily A) family are characterized by their ability to transport lipids across cellular membranes and regulate lipid homoeostasis in the brain and peripheral tissues. ABCA8 is a little-known member of this
Autor:
Yean J. Lim, Martin D. Rees, Tito S Sempértegui Plaza, Elias N. Glaros, Amanda W. S. Yeung, XiaoSuo Wang, Shane R. Thomas, Mohammed Freewan, Paul K. Witting, Andrew C. Terentis
Publikováno v:
Journal of Biological Chemistry. 288:1548-1567
The heme enzyme indoleamine 2,3-dioxygenase (IDO) is a key regulator of immune responses through catalyzing l-tryptophan (l-Trp) oxidation. Here, we show that hydrogen peroxide (H(2)O(2)) activates the peroxidase function of IDO to induce protein oxi
Autor:
Jimmy F.P. Berbée, Kerry-Anne Rye, Diana Nawara, Peter J. Meikle, Betty Leung, Leonard Kritharides, Maaike Kockx, Theodore W.K. Ng, Patrick C.N. Rensen, Carmel M. Quinn, Elias N. Glaros, Virginie Deswaerte, Wendy Jessup
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology, 36(7), 1338-+. LIPPINCOTT WILLIAMS & WILKINS
Objective— Cyclosporin A (CsA) is an immunosuppressant commonly used to prevent organ rejection but is associated with hyperlipidemia and an increased risk of cardiovascular disease. Although studies suggest that CsA-induced hyperlipidemia is media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035374aaac397e4a1d467235dbac82d6
https://hdl.handle.net/1887/99415
https://hdl.handle.net/1887/99415
Autor:
Kathy Knezevic, Heather Campbell, Deborah Packham, John E. Pimanda, Elias N. Glaros, Vivien M. Chen, Louise E. Purton, Robyn L. Ward, Vashe Chandrakanthan, Yizhou Huang, Thuan Thai, Panagiotis Papathanasiou, Shane R. Thomas, Amanda W. S. Yeung, Robert Tunningley, Jason W. H. Wong, Luke B. Hesson, Qiao Qiao, Julie A. I. Thoms, Belinda Whittle, Jia Jenny Liu
Publikováno v:
Molecular and cellular biology. 36(8)
© 2016, American Society for Microbiology. All Rights Reserved. Dihydrofolate reductase (DHFR) is a critical enzyme in the folate metabolism pathway and also plays a role in regulating nitric oxide (NO) signaling in endothelial cells. Although both