Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Elias Lolis"'
Autor:
Federica Maschietto, Tianyin Qiu, Jimin Wang, Yuanjun Shi, Brandon Allen, George P. Lisi, Elias Lolis, Victor S. Batista
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1066-1076 (2023)
The receptor-binding domains (RBDs) of the SARS-CoV-2 spike trimer exhibit ''up'' and ''down'' conformations often targeted by neutralizing antibodies. Only in the “up” configuration can RBDs bind to the ACE2 receptor of the host cell and initiat
Externí odkaz:
https://doaj.org/article/5916798c559645fa85848f4bb9e34d7b
Autor:
Jimin Wang, Federica Maschietto, Matthew J. Guberman-Pfeffer, Krystle Reiss, Brandon Allen, Yong Xiong, Elias Lolis, Victor S. Batista
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5019-5028 (2021)
The membrane fusion mechanism of SARS-CoV-2 offers an attractive target for the development of small molecule antiviral inhibitors. Fusion involves an initial binding of the crown-like trimeric spike glycoproteins of SARS-CoV-2 to the receptor angiot
Externí odkaz:
https://doaj.org/article/f6f0bc0fd4aa45f6ac162a5959e07d1f
Autor:
James W. Murphy, Deepa Rajasekaran, Janie Merkel, Erin Skeens, Camille Keeler, Michael E. Hodsdon, George P. Lisi, Elias Lolis
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
CXCL12 activates CXCR4 and is involved in embryogenesis, hematopoiesis, and angiogenesis. It has pathological roles in HIV-1, WHIM disease, cancer, and autoimmune diseases. An antagonist, AMD3100, is used for the release of CD34+ hematopoietic stem c
Externí odkaz:
https://doaj.org/article/40fb3af75ca148da8d1fef2ed5c15c09
Autor:
Jimin Wang, Yuanjun Shi, Krystle Reiss, Federica Maschietto, Elias Lolis, William H. Konigsberg, George P. Lisi, Victor S. Batista
Publikováno v:
Biochemistry. 61:1966-1973
Remdesivir is an adenosine analogue that has a cyano substitution in the C1' position of the ribosyl moiety and a modified base structure to stabilize the linkage of the base to the C1' atom with its strong electron-withdrawing cyano group. Within th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6296e0f3d24eb8b117db2d90b346328
https://doi.org/10.1021/acs.biochem.2c00341
https://doi.org/10.1021/acs.biochem.2c00341
Autor:
Robert A. Mitchell, John O. Trent, Elias Lolis, Ned Smith, Lin Leng, Richard Bucala, Randall Riggs, Gregg V. Crichlow, Beatriz E. Rendon, Swen Zierow, Jason Meier, Millicent Winner
Supplementary Table 1 from A Novel, Macrophage Migration Inhibitory Factor Suicide Substrate Inhibits Motility and Growth of Lung Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1cfe870f6b70a25b62f983aaa42c32
https://doi.org/10.1158/0008-5472.22374359
https://doi.org/10.1158/0008-5472.22374359
Autor:
Jimin Wang, Yuanjun Shi, Krystle Reiss, Brandon Allen, Federica Maschietto, Elias Lolis, William H. Konigsberg, George P. Lisi, Victor S. Batista
Publikováno v:
Biochemistry. 61:424-432
A minimal replication-transcription complex (RTC) of SARS-CoV-2 for synthesis of viral RNAs includes the nsp12 RNA-dependent RNA polymerase and two nsp8 RNA primase subunits for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2189129e0b2373f6747c690fbad2040
https://doi.org/10.1021/acs.biochem.1c00755
https://doi.org/10.1021/acs.biochem.1c00755
Autor:
Lukas Spiller, Ramu Manjula, Franz Leissing, Jerome Basquin, Priscila Bourilhon, Dzmitry Sinitski, Markus Brandhofer, Sophie Levecque, Björn Sabelleck, Regina Feederle, Andrew Flatley, Ralph Panstruga, Jürgen Bernhagen, Elias Lolis
Vertebrates have developed effective immune mechanisms to fight microbial attacks, relying on a sophisticated network of innate and adaptive responses, a circulatory system, and numerous orchestrating soluble mediators such as cytokines. Mammalian ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d624cbc9ee5a741f0eedb9fb1407347
https://doi.org/10.1101/2023.01.30.525655
https://doi.org/10.1101/2023.01.30.525655
Publikováno v:
Biochemistry
Remdesivir is an antiviral drug initially designed against the Ebola virus. The results obtained with it both in biochemical studies in vitro and in cell line assays in vivo were very promising, but it proved to be ineffective in clinical trials. Rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5972d77969cfb19e78b4464d2499e480
https://doi.org/10.1021/acs.biochem.1c00292
https://doi.org/10.1021/acs.biochem.1c00292
Autor:
Yong Xiong, Krystle Reiss, Jimin Wang, Victor S. Batista, Federica Maschietto, Elias Lolis, Brandon Allen, Matthew J. Guberman-Pfeffer
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 5019-5028 (2021)
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 5019-5028 (2021)
Graphical abstract
The membrane fusion mechanism of SARS-CoV-2 offers an attractive target for the development of small molecule antiviral inhibitors. Fusion involves an initial binding of the crown-like trimeric spike glycoproteins of SARS-CoV-
The membrane fusion mechanism of SARS-CoV-2 offers an attractive target for the development of small molecule antiviral inhibitors. Fusion involves an initial binding of the crown-like trimeric spike glycoproteins of SARS-CoV-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9460c23cb790c9110f195d53bfdc11c
https://doi.org/10.1016/j.csbj.2021.08.053
https://doi.org/10.1016/j.csbj.2021.08.053
Autor:
James W. Murphy, Eric M. Rosenberg, Georgios Pantouris, James Herrington, Elias Lolis, Deepa Rajasekaran
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
The chemokine CXCL13 relies on its N-terminus for signaling, but minor length and side-chain variations still result in a agonistic forms of the protein. Two crystal structures reveal that both the N-terminus and the C-terminal extension of the prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4878b14b6e42a11d853072b4bef65109
https://doi.org/10.1107/s2059798320011687
https://doi.org/10.1107/s2059798320011687