Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Elias K Halvas"'
Autor:
Shuang Guo, Brian T Luke, Amy R Henry, Samuel Darko, Leah D Brandt, Ling Su, David Sun, Daria Wells, Kevin W Joseph, Dimiter Demirov, Elias K Halvas, Daniel C Douek, Xiaolin Wu, John W Mellors, Stephen H Hughes
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8, p e1010726 (2022)
Although combination antiretroviral therapy (ART) blocks HIV replication, it is not curative because infected CD4+ T cells that carry intact, infectious proviruses persist. Understanding the behavior of clones of infected T cells is important for und
Externí odkaz:
https://doaj.org/article/e4d901c328ff4314aeae578f4ca25641
Autor:
John K Bui, Elias K Halvas, Elizabeth Fyne, Michele D Sobolewski, Dianna Koontz, Wei Shao, Brian Luke, Feiyu F Hong, Mary F Kearney, John W Mellors
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006230 (2017)
The fate of HIV-infected cells after reversal of proviral latency is not well characterized. Simonetti, et al. recently showed that CD4+ T-cells containing intact proviruses can clonally expand in vivo and produce low-level infectious viremia. We hyp
Externí odkaz:
https://doaj.org/article/ee331779609b446789aaefe54e5f381a
Autor:
Mark A. Marzinke, Jessica M. Fogel, Zhe Wang, Estelle Piwowar-Manning, Ryan Kofron, Amber Moser, Pradip Bhandari, Ryann Gollings, Lane R. Bushman, Lei Weng, Elias K. Halvas, John Mellors, Peter L. Anderson, Deborah Persaud, Craig W. Hendrix, Marybeth McCauley, Alex R. Rinehart, Marty St Clair, Susan L. Ford, James F. Rooney, Adeola Adeyeye, Suwat Chariyalertsak, Kenneth Mayer, Roberto C. Arduino, Myron S. Cohen, Beatriz Grinsztejn, Brett Hanscom, Raphael J. Landovitz, Susan H. Eshleman
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
HPTN 083 demonstrated that injectable cabotegravir (CAB) was superior to oral tenofovir disoproxil fumarate-emtricitabine (TDF-FTC) for HIV prevention in cisgender men and transgender women who have sex with men. We previously analyzed 58 infections
Autor:
Kevin W. Joseph, Elias K. Halvas, Leah D. Brandt, Sean C. Patro, Jason W. Rausch, Abha Chopra, Simon Mallal, Mary F. Kearney, John M. Coffin, John W. Mellors
Publikováno v:
Journal of virology. 96(13)
The integration of human immunodeficiency virus type 1 (HIV-1) into chromosomal DNA establishes the long-term persistence of HIV-1 as proviruses despite effective antiretroviral therapy (ART). Characterizing proviruses is difficult because of their r
Autor:
Joshua C. Cyktor, Jason W. Rausch, Wei Shao, Camille Tumiotto, Elias K. Halvas, Michael J. Bale, John W. Mellors, Mary F. Kearney, John M. Coffin, Michele D. Sobolewski, John K. Bui, Jana L. Jacobs, Shuang Guo, Leah D. Brandt, Kevin W. Joseph, Brandon F. Keele, Stephen H. Hughes, Xiaolin Wu, Gene D. Morse
Publikováno v:
J Clin Invest
BACKGROUNDHIV-1 viremia that is not suppressed by combination antiretroviral therapy (ART) is generally attributed to incomplete medication adherence and/or drug resistance. We evaluated individuals referred by clinicians for nonsuppressible viremia
Autor:
John M. Coffin, Rebecca Hoh, Jason W. Rausch, Brandon F. Keele, Frank Maldarelli, Sean C Patro, Christine M. Fennessey, Shuang Guo, Christopher Hautman, Leah D. Brandt, Brian T. Luke, Elias K. Halvas, Steven G. Deeks, Kevin W. Joseph, Wei Shao, Michael J. Bale, Adam A. Capoferri, Aurelie Niyongabo, Michele D. Sobolewski, Jonathan Spindler, Xiaolin Wu, Jeffrey M. Milush, Stephen H. Hughes, Ben Murrell, John W. Mellors, Castle Raley, Mary F. Kearney, Jenna M Hasson, Wei-Shau Hu, Ann Wiegand
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 51
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Understanding HIV-1 persistence despite antiretroviral therapy (ART) is of paramount importance. Both single-genome sequencing (SGS) and integration site analysis (ISA) provide useful information regarding the structure of persistent HIV DNA populati
Autor:
Rahil Sethi, Daniel W. Szydlo, Amy Heaps, John W. Mellors, Urvi M. Parikh, Elias K. Halvas, William E. Schwarzmann, Jared M. Baeten, Uma R. Chandran, Thesla Palanee-Phillips, Marla Husnik, Russell L. Hardesty, Kelley C. Gordon, Mtn Study Team, B Jay Goetz, Kerri J. Penrose
Publikováno v:
Journal of the International AIDS Society
Introduction A potential concern with the use of dapivirine (DPV) for HIV prevention is the selection of a drug‐resistant virus that could spread and reduce the effectiveness of non‐nucleoside reverse transcriptase (NNRTI)‐based first‐line an
Autor:
Leah D. Brandt, Elias K. Halvas, Xiaolin Wu, Shuang Guo, Dimiter Demirov, Ling Su, John W. Mellors, Beth Scott, Aaron T. Hamilton, Kevin W. Joseph, Baktiar Karim, Asma Naqvi, Zhonghe Sun, Donna Butcher, Stephen H. Hughes, Marintha Heil
Publikováno v:
Science Advances. 7
Retroviruses cause cancers in animals by integrating in or near oncogenes. Although HIV-1 infection increases the risk of cancer, most of the risk is associated with immunodeficiency and coinfection by oncogenic virus (Epstein-Barr virus, Kaposi sarc
Autor:
John W, Mellors, Shuang, Guo, Asma, Naqvi, Leah D, Brandt, Ling, Su, Zhonghe, Sun, Kevin W, Joseph, Dimiter, Demirov, Elias K, Halvas, Donna, Butcher, Beth, Scott, Aaron, Hamilton, Marintha, Heil, Baktiar, Karim, Xiaolin, Wu, Stephen H, Hughes
Publikováno v:
Science Advances
Description
HIV-1 proviruses in the first introns of STAT3 and LCK can contribute to the development of T cell lymphomas.
Retroviruses cause cancers in animals by integrating in or near oncogenes. Although HIV-1 infection increases the risk
HIV-1 proviruses in the first introns of STAT3 and LCK can contribute to the development of T cell lymphomas.
Retroviruses cause cancers in animals by integrating in or near oncogenes. Although HIV-1 infection increases the risk
Autor:
Joshua C. Cyktor, Wei Shao, Ann Wiegand, Elias K. Halvas, Daria Wells, John M. Coffin, Xiaolin Wu, Gert U. van Zyl, Jonathan Spindler, Mary Grace Katusiime, Mark F. Cotton, John W. Mellors, Stephen H. Hughes, Michael J. Bale, Mary F. Kearney
Publikováno v:
mBio
mBio, Vol 12, Iss 2 (2021)
mBio, Vol 12, Iss 2 (2021)
HIV-1 integrates its genome into the DNA of host cells. Consequently, HIV-1 genomes are copied with the host cell DNA during cellular division.
Little is known about the emergence and persistence of human immunodeficiency virus (HIV)-infected T-
Little is known about the emergence and persistence of human immunodeficiency virus (HIV)-infected T-