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Akademický článek

'Addressing barriers to digital health readiness among a Latino population'

Autor: Karla Martin González, Alexzandra T. Gentsch, Chelsea Torres, Elias Borne, Josefina Hendry, Lianette Pappaterra, Maryann Salib, Brooke Worster, Steven Gravier-Leon, Kristin L. Rising

Publikováno v: PEC Innovation, Vol 5, Iss , Pp 100336- (2024)

Objective: There are many potential barriers to an individual's readiness and ability to use telehealth, including technology access, trust and knowledge. This qualitative study was a partnership between Jefferson and Esperanza Health Center (EHC), f

Externí odkaz: https://doaj.org/article/299c867d876c42928111fca9053d906d

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Akademický článek

Recommendations from people who use drugs in Philadelphia, PA about structuring point-of-care drug checking

Autor: Megan K. Reed, Elias Borne, Tracy Esteves Camacho, Morgan Kelly, Kristin L. Rising

Publikováno v: Harm Reduction Journal, Vol 21, Iss 1, Pp 1-12 (2024)

Abstract Background Adulterants, such as fentanyl and xylazine, among others, are present in a high percentage of the illicit drug supply, increasing the risk for overdose and other adverse health events among people who use drugs (PWUD). Point-of-ca

Externí odkaz: https://doaj.org/article/9b1bc2991c1944aea0ce83ee9168ca7f

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Simulations of the regulatory ACT domain of human phenylalanine hydroxylase (PAH) unveil its mechanism of phenylalanine binding

Autor: Emilia C. Arturo, Yunhui Ge, Shannon Stewart, Michael Hansen, Elias Borne, Eileen K. Jaffe, Vincent A. Voelz

Publikováno v: Journal of Biological Chemistry. 293:19532-19543

Phenylalanine hydroxylase (PAH) regulates phenylalanine (Phe) levels in mammals to prevent neurotoxicity resulting from high Phe concentrations as observed in genetic disorders leading to hyperphenylalaninemia and phenylketonuria. PAH senses elevated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e309a084b41ae20a51fea6c16964845
https://doi.org/10.1074/jbc.ra118.004909

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Biophysical characterization of full-length human phenylalanine hydroxylase provides a deeper understanding of its quaternary structure equilibrium

Autor: Emilia C. Arturo, Elias Borne, Kushol Gupta, Eileen K. Jaffe, Michael Hansen

Publikováno v: J Biol Chem

Dysfunction of human phenylalanine hydroxylase (hPAH, EC 1.14.16.1) is the primary cause of phenylketonuria, the most common inborn error of amino acid metabolism. The dynamic domain rearrangements of this multimeric protein have thwarted structural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0edc4b24c0f15645c87f6f5a11ae5c5c
https://pubmed.ncbi.nlm.nih.gov/31076506

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Amino Acid Substitution at Phe80 of Mammalian Phenylalanine Hydroxylase Destabilizes Both Resting‐State and Activated Conformations Increasing the Population of Intermediates

Autor: Michael Hansen, Kushol Gupta, Eileen K. Jaffe, Sophia Lisowski, Emilia C. Arturo, George Merkel, Elias Borne

Publikováno v: The FASEB Journal. 34:1-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6213514a6f6ecfb4f90eff054b34a711
https://doi.org/10.1096/fasebj.2020.34.s1.06346

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Single-residue variants of phenylalanine hydroxylase help to observe multiple structural isoforms that comprise the structural equilibrium

Autor: Michael Hansen, Emilia C. Arturo, Elias Borne, Eileen K. Jaffe

Publikováno v: Acta Crystallographica Section A Foundations and Advances. 74:a216-a216

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d71736c8ebdce4da8da815336e2c3d6e
https://doi.org/10.1107/s0108767318097830

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