Hepatitis C virus controls interferon production through PKR activation.

Autor: Noëlla Arnaud, Stéphanie Dabo, Patrick Maillard, Agata Budkowska, Katerina I Kalliampakou, Penelope Mavromara, Dominique Garcin, Jacques Hugon, Anne Gatignol, Daisuke Akazawa, Takaji Wakita, Eliane F Meurs

Publikováno v: PLoS ONE, Vol 5, Iss 5, p e10575 (2010)

Hepatitis C virus is a poor inducer of interferon (IFN), although its structured viral RNA can bind the RNA helicase RIG-I, and activate the IFN-induction pathway. Low IFN induction has been attributed to HCV NS3/4A protease-mediated cleavage of the

Externí odkaz: https://doaj.org/article/bed02c5ca7014576bb11fe7b1fbd733a

Retinoic Acid Inducible Gene I and Protein Kinase R, but Not Stress Granules, Mediate the Proinflammatory Response to Yellow Fever Virus

Autor: Maxime Chazal, Sarah Lesage, Takashi Fujita, Ségolène Gracias, Eliane F. Meurs, Laura Sinigaglia, Frédéric Tangy, Daniela Bruni, Felix Streicher, Guillaume Beauclair, Salomé Bourgeau, Nolwenn Jouvenet

Publikováno v: J Virol
Journal of Virology
Journal of Virology, 2020, 94 (22), pp.e00403-20. ⟨10.1128/JVI.00403-20⟩
Journal of Virology, American Society for Microbiology, 2020, 94 (22), pp.e00403-20. ⟨10.1128/JVI.00403-20⟩

International audience; Yellow fever virus (YFV) is an RNA virus primarily targeting the liver. Severe YF cases are responsible for hemorrhagic fever, plausibly precipitated by excessive proinflammatory cytokine response. Pathogen recognition recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658b3789c6d6a44b048370894bf30abf
https://pubmed.ncbi.nlm.nih.gov/32878892

Genetic variations in toll-like receptors 7 and 8 modulate natural hepatitis C outcomes and liver disease progression

Autor: Mustapha Lkhider, Rhimou Alaoui, Eliane F. Meurs, Pascal Pineau, Soumaya Benjelloun, Fatima-Zohra Fakhir, Sayeh Ezzikouri, Wafaa Badre

Publikováno v: Liver International
Liver International, Wiley-Blackwell, 2018, 38 (3), pp.432-442. ⟨10.1111/liv.13533⟩
Liver International, 2018, 38 (3), pp.432-442. ⟨10.1111/liv.13533⟩

Background & Aims The natural outcomes of hepatitis C virus (HCV) as well as the progression of the liver disease are highly variable and depend primarily on an efficient immune response. As Toll-like receptors 7 (TLR7) and 8 (TLR8) are important eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4640cb6e6dcd6d41d63827ee5b9264
https://doi.org/10.1111/liv.13533

Differential regulation of the Wnt/β-catenin pathway by hepatitis C virus recombinants expressing core from various genotypes

Autor: Annette Martin, Brigitte Blumen, Stephanie Aicher, Eliane F. Meurs, Penelope Mavromara, Athanasios Kakkanas, Lisette Cohen, Richard Njouom, Gabriela Oprişan

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp.11185. ⟨10.1038/s41598-018-29078-2⟩
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports, 2018, 8 (1), pp.11185. ⟨10.1038/s41598-018-29078-2⟩

Clinical studies have suggested association of some hepatitis C virus (HCV) subtypes or isolates with progression toward hepatocellular carcinoma (HCC). HCV core protein has been reported to interfere with host Wnt/β-catenin pathway, a cell fate-det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc44ef9a207518b82f7ac0d08a16917c
https://hal-pasteur.archives-ouvertes.fr/pasteur-02896787/document

A potential robust antiviral defense state in the common vampire bat: Expression, induction and molecular characterization of the three interferon-stimulated genes -OAS1, ADAR1 and PKR

Autor: Stéphanie Dabo, Christine Neuveut, Vincent Lacoste, Marie-Claude Lise, Eliane F. Meurs, Anne Lavergne, Sarkis Sarkis

Publikováno v: Developmental and Comparative Immunology
Developmental and Comparative Immunology, 2018, 85, pp.95-107. ⟨10.1016/J.DCI.2018.04.006⟩
Developmental and Comparative Immunology, Elsevier, 2018, 85, pp.95-107. ⟨10.1016/J.DCI.2018.04.006⟩

Bats are known to harbor many zoonotic viruses, some of which are pathogenic to other mammals while they seem to be harmless in bats. As the interferon (IFN) response represents the first line of defense against viral infections in mammals, it is hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e58b3847c55cac981f1ea20ac5c8f2
https://pubmed.ncbi.nlm.nih.gov/29635006