Výsledky vyhledávání - "Eliana S. Armstrong"

Akademický článek

Outcomes of high-dose levofloxacin therapy remain bound to the levofloxacin minimum inhibitory concentration in complicated urinary tract infections

Autor: Eliana S. Armstrong, Janelle A. Mikulca, Daniel J. Cloutier, Caleb A. Bliss, Judith N. Steenbergen

Publikováno v: BMC Infectious Diseases, Vol 16, Iss 1, Pp 1-6 (2016)

Abstract Background Fluoroquinolones are a guideline-recommended therapy for complicated urinary tract infections, including pyelonephritis. Elevated drug concentrations of fluoroquinolones in the urine and therapy with high-dose levofloxacin are bel

Externí odkaz: https://doaj.org/article/d8ad02f39611496d91cd976cefa11988

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A Multicenter, Randomized, Double-Blind, Phase 2 Study of the Efficacy and Safety of Plazomicin Compared with Levofloxacin in the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis

Autor: Deborah S Cebrik, Eliana S. Armstrong, Loren G. Miller, Valerie Riddle, Lynn E. Connolly

Publikováno v: Antimicrobial Agents and Chemotherapy. 62

Increasing antimicrobial resistance among uropathogens limits treatment options for patients with complicated urinary tract infection (cUTI). Plazomicin, a new aminoglycoside, has in vitro activity against multidrug-resistant Enterobacteriaceae , inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1095bcd1a926d0aab4083dd884a9b1c0
https://doi.org/10.1128/aac.01989-17

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1364. Efficacy of Omadacycline Against Molecularly Characterized Gram-Positive and Gram-Negative Pathogens Causing Infections in the Phase 3 CABP and ABSSSI Clinical Trials

Autor: Eliana S. Armstrong, Robert K. Flamm, Mariana Castanheira, Judith N. Steenbergen, Rodrigo E. Mendes

Publikováno v: Open Forum Infectious Diseases

Background Omadacycline (OMC) is a once-daily agent with IV and oral formulations. One Phase 3 trial for community-acquired bacterial pneumonia (CABP; OPTIC) and two Phase 3 trials for acute bacterial skin and skin structure infections (ABSSSI; OASIS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545169a7c5fbc5ce86fd663c4e599daf
https://doi.org/10.1093/ofid/ofy210.1195

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1377. Omadacycline In Vitro Activity Against a Molecularly Characterized Collection of Clinical Isolates with Known Tetracycline Resistance Mechanisms

Autor: Mariana Castanheira, Robert K. Flamm, Rodrigo E. Mendes, Judith N. Steenbergen, Eliana S. Armstrong

Publikováno v: Open Forum Infectious Diseases

Background Omadacycline is a novel aminomethylcycline that recently completed Phase 3 clinical trials for the treatment of acute bacterial skin and skin structure infections (ABSSSIs) and community-acquired bacterial pneumonia (CABP). This study eval

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7d48b88263139ad373e34125840f01
http://europepmc.org/articles/PMC6253154

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In Vitro Activity of Ceftolozane-Tazobactam against Anaerobic Organisms Identified during the ASPECT-cIAI Study

Autor: Judith N. Steenbergen, Eliana S. Armstrong, David J. Farrell, Melissa Palchak

Publikováno v: Antimicrobial agents and chemotherapy. 60(1)

The in vitro activities of ceftolozane-tazobactam, meropenem, and metronidazole were determined against anaerobic organisms isolated from patients with complicated intraabdominal infections (cIAI) in global phase III studies. Ceftolozane-tazobactam a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7673340b6af2a24892085610bb43d85
https://pubmed.ncbi.nlm.nih.gov/26552971

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Detection of Methyltransferases Conferring High-Level Resistance to Aminoglycosides in Enterobacteriaceae from Europe, North America, and Latin America

Autor: Ronald N. Jones, Mariana Castanheira, Eliana S. Armstrong, Thomas R. Fritsche, George H. Miller

Publikováno v: Antimicrobial Agents and Chemotherapy. 52:1843-1845

The alteration of ribosomal targets by recently described 16S rRNA methyltransferases confers resistance to most aminoglycosides, including arbekacin. Enterobacteriaceae and nonfermentative bacilli acquired through global surveillance programs were s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6123dca581d2eb7fb3c33b8b249fa8
https://doi.org/10.1128/aac.01477-07

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BTI1, an azoreductase with pH-dependent substrate specificity

Autor: Margaret A. Roy, Albert Wong, Richard E. Grant, Hans E. Johansson, Erik J. Peterson, Eliana S. Armstrong, Mary Katherine Johansson, Ronald M. Cook, Mark V. Reddington

Publikováno v: Applied and environmental microbiology. 77(12)

The group II azoreductase BTI1 utilizes NADPH to directly cleave azo bonds in water-soluble azo dyes, including quenchers of fluorescence. Unexpectedly, optimal reduction was dye specific, ranging from a pH of 8.3 for flame orange.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c91b5506ac0d2db25a6c703eb5b9aaf
https://pubmed.ncbi.nlm.nih.gov/21531830

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