Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Eliana M. Barros"'
Autor:
Kienan I. Savage, Grant S. Stewart, D. Paul Harkin, Ken I. Mills, Melissa J. La Bonte, Cheryl Latimer, Fabio G. Liberante, Hayley McMillan, Gareth W. Irwin, Satpal S. Jhujh, Eliana M. Barros, Katrina M. Lappin
Supplementary Data from Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e250212f00f5cee0275162a86dd3d0
https://doi.org/10.1158/0008-5472.22430763
https://doi.org/10.1158/0008-5472.22430763
Autor:
Kienan I. Savage, Grant S. Stewart, D. Paul Harkin, Ken I. Mills, Melissa J. La Bonte, Cheryl Latimer, Fabio G. Liberante, Hayley McMillan, Gareth W. Irwin, Satpal S. Jhujh, Eliana M. Barros, Katrina M. Lappin
Mutations in SF3B1 have been identified across several cancer types. This key spliceosome component promotes the efficient mRNA splicing of thousands of genes including those with crucial roles in the cellular response to DNA damage. Here, we demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::364cc5b93440e42b205c4d417aa934cb
https://doi.org/10.1158/0008-5472.c.6513714.v1
https://doi.org/10.1158/0008-5472.c.6513714.v1
Autor:
Kienan I. Savage, Grant S. Stewart, D. Paul Harkin, Ken I. Mills, Melissa J. La Bonte, Cheryl Latimer, Fabio G. Liberante, Hayley McMillan, Gareth W. Irwin, Satpal S. Jhujh, Eliana M. Barros, Katrina M. Lappin
Supplementary Table from Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8b72cb731bca85602ae22e3e680e94
https://doi.org/10.1158/0008-5472.22430757
https://doi.org/10.1158/0008-5472.22430757
Autor:
D. Paul Harkin, Christopher T. Elliott, Derek J. Richard, Manuel Salto-Tellez, Stuart A. McIntosh, Kevin M. Prise, Ben Ho Park, Simon S. McDade, Lorenzo Manti, Alexander Powell, Angelina F. Madden, Joy N. Kavanagh, Jekaterina Vohhodina, Katy S. Orr, Julia J. Gorski, Gareth W. Irwin, Kevin M. Cooper, Eliana M. Barros, Kyle B. Matchett, Kienan I. Savage
PDF file - 2823K, Supplementary Figure 1. Estrogen metabolites cause DNA double strand breaks in S- phase cells. Supplementary Figure 2. BRCA1 supresses estrogen metabolite mediated DSBs and is required for their repair. Supplementary Figure 3. Estro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6645350cb792a59baf4945077f274e6b
https://doi.org/10.1158/0008-5472.22398495.v1
https://doi.org/10.1158/0008-5472.22398495.v1
Autor:
D. Paul Harkin, Christopher T. Elliott, Derek J. Richard, Manuel Salto-Tellez, Stuart A. McIntosh, Kevin M. Prise, Ben Ho Park, Simon S. McDade, Lorenzo Manti, Alexander Powell, Angelina F. Madden, Joy N. Kavanagh, Jekaterina Vohhodina, Katy S. Orr, Julia J. Gorski, Gareth W. Irwin, Kevin M. Cooper, Eliana M. Barros, Kyle B. Matchett, Kienan I. Savage
PDF file - 75K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52164a60ccc310e76bd92b2c75e90088
https://doi.org/10.1158/0008-5472.22398498
https://doi.org/10.1158/0008-5472.22398498
Autor:
Katrina M. Lappin, Eliana M. Barros, Satpal S. Jhujh, Gareth W. Irwin, Hayley McMillan, Fabio G. Liberante, Cheryl Latimer, Melissa J. La Bonte, Ken I. Mills, D. Paul Harkin, Grant S. Stewart, Kienan I. Savage
Publikováno v:
Lappin, K M, Barros, E M, Jhujh, S S, Irwin, G W, McMillan, H, Liberante, F G, Latimer, C, LaBonte, M J, Mills, K I, Harkin, D P, Stewart, G S & Savage, K I 2022, ' Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors ', Cancer Research, vol. 82, no. 5, pp. 819-830 . https://doi.org/10.1158/0008-5472.CAN-21-1843
Cancer Res
Cancer Res
Mutations in SF3B1 have been identified across several cancer types. This key spliceosome component promotes the efficient mRNA splicing of thousands of genes including those with crucial roles in the cellular response to DNA damage. Here, we demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8583de82348cd7f0370c472d20963c86
https://doi.org/10.1158/0008-5472.can-21-1843
https://doi.org/10.1158/0008-5472.can-21-1843
Autor:
Richard D. Kennedy, Kienan Savage, Richard D A Wilkinson, Katrina M. Lappin, Stuart McIntosh, Roger A. Greenberg, Eileen Parkes, Eliana M. Barros, David Johnston, Nuala McCabe, Denis Paul Harkin, Rayhaan M.M. Ali
Tumours with genomic instability demonstrate enhanced immunogenicity and potential for response to immune checkpoint blockade (ICB). We previously demonstrated activation of the cGAS-STING pathway following loss of DNA repair, resulting in cytokine i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068685f1474980ce5318286b0872d3e1
https://doi.org/10.1101/764662
https://doi.org/10.1101/764662
Autor:
Manuel Salto-Tellez, Andrea Pellagatti, Kienan I. Savage, Dennis J. McCance, Gareth W. Irwin, W. Glenn McCluggage, D. Paul Harkin, Derek J. Richard, Eliana M. Barros, Jacqueline Boultwood, Julia J. Gorski, Giuseppe Schettino, Alexander J. Powell, Lorenzo Manti, Natalia Lukashchuk, Simon S. McDade
Publikováno v:
Molecular Cell
Savage, K I, Gorski, J J, Barros, E M, Irwin, G W, Manti, L, Powell, A J, Pellagatti, A, Lukashchuk, N, McCance, D J, McCluggage, W G, Schettino, G, Salto-Tellez, M, Boultwood, J, Richard, D J, McDade, S S & Harkin, D P 2014, ' Identification of a BRCA1-mRNA Splicing Complex Required for Efficient DNA Repair and Maintenance of Genomic Stability ', Molecular Cell, vol. 54, no. 3, pp. 445-459 . https://doi.org/10.1016/j.molcel.2014.03.021
Savage, K I, Gorski, J J, Barros, E M, Irwin, G W, Manti, L, Powell, A J, Pellagatti, A, Lukashchuk, N, McCance, D J, McCluggage, W G, Schettino, G, Salto-Tellez, M, Boultwood, J, Richard, D J, McDade, S S & Harkin, D P 2014, ' Identification of a BRCA1-mRNA Splicing Complex Required for Efficient DNA Repair and Maintenance of Genomic Stability ', Molecular Cell, vol. 54, no. 3, pp. 445-459 . https://doi.org/10.1016/j.molcel.2014.03.021
Summary Mutations within BRCA1 predispose carriers to a high risk of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through the assembly of multiple protein complexes involved in DNA repair, cell-cycle arrest, and transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613a82001de26e4f5af73828458714ad
https://pubmed.ncbi.nlm.nih.gov/24746700
https://pubmed.ncbi.nlm.nih.gov/24746700
Autor:
Julia J. Gorski, Paul B. Mullan, Mary T. Harte, J W Purcell, Eliana M. Barros, P M Burn, Kienan I. Savage, Neil D. Perkins, Richard D. Kennedy, D. P. Harkin, C McFarlane
Publikováno v:
Oncogene
BRCA1 mediates resistance to apoptosis in response to DNA-damaging agents, causing BRCA1 wild-type tumours to be significantly more resistant to DNA damage than their mutant counterparts. In this study, we demonstrate that following treatment with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb393171aa9127c2f9b416c8a19c41b6
https://pubmed.ncbi.nlm.nih.gov/23435429
https://pubmed.ncbi.nlm.nih.gov/23435429
Publikováno v:
European Journal of Cancer. 50:S75
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e307341f39f63615fe2f339dbc69daf2
https://doi.org/10.1016/s0959-8049(14)50280-8
https://doi.org/10.1016/s0959-8049(14)50280-8