Výsledky vyhledávání - "Eliahu Roubini"

A novel, mild, specific and indirect maleimido-based radioiodolabeling method

Autor: Chih‐Tai Leu, Michael Chorev, Eliahu Roubini, Roberta L. McKee, Michael P. Caulfield, Jay J. Levy, Michael Rosenblatt, Susan W. Gibbons

Publikováno v: International Journal of Peptide and Protein Research. 40:445-455

In an effort to design a mild, non-oxidative and site-specific means of radiolabeling bioactive molecules we have employed maleimido-sulfhydryl chemistry to produce bioactive hormone radioligands. We have prepared two novel radioiodolabeled reagents,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06e19d9246f4abe44d105146e3ebf2c0
https://doi.org/10.1111/j.1399-3011.1992.tb00323.x

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Biological activity of parathyroid hormone antagonists substituted at position 13

Autor: Michael Chorev, Mark E. Goldman, Michael P. Caulfield, Eliahu Roubini, Jane E. Reagan, Susan W. Gibbons, Roberta L. McKee, Michael Rosenblatt

Publikováno v: Peptides. 12:57-62

Lysine occupies position 13 in the parathyroid hormone (PTH) antagonist, [Nle8,18,Tyr34]bPTH(7-34)NH2. Acylation of the epsilon-amino group in lysine 13 by a hydrophobic moiety is well tolerated in terms of bioactivity: the analog [Nle8,18, D-Trp12,L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de21b097485f4d04764449094b962de8
https://doi.org/10.1016/0196-9781(91)90167-n

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The Bovine Renal Parathyroid Hormone (PTH) Receptor Has Equal Affinity for Two Different Amino Acid Sequences: The Receptor Binding Domains of PTH and PTH-Related Protein Are Located within the 14–34 Region

Autor: MICHAEL P. CAULFIELD, ROBERTA L. McKEE, MARK E. GOLDMAN, LE T. DUONG, JOHN E. FISHER, C. THOMAS GAY, PATRICIA A. DEHAVEN, JAY J. LEVY, ELIAHU ROUBINI, RUTH F. NUTT, MICHAEL CHOREV, MICHAEL ROSENBLATT

Publikováno v: Endocrinology. 127:83-87

Previous studies examining the interaction of PTH and PTH-related protein (PTHrP) with target tissue have for the most part emphasized the similarity between the two hormones in binding to and activating receptors. This observation that two peptides

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acfed5e2397c2ec78e77e101002356e
https://doi.org/10.1210/endo-127-1-83

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Synthesis of fully active biotinylated analogues of parathyroid hormone and parathyroid hormone-related protein as tools for the characterization of parathyroid hormone receptors

Autor: Michael Chorev, Chih T. Leu, Michael P. Caulfield, Le T. Duong, Michael Rosenblatt, Susan W. Gibbons, Eliahu Roubini

Publikováno v: Biochemistry. 31(16)

The synthesis, purification, and characterization of biotinylated analogues of parathyroid hormone (PTH) and PTH-related protein (PTHrP) are described. A novel methodology was developed which allowed the selective biotinylation during solid-phase syn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e10ae6672e05bc3b9dcb17e98543bd
https://pubmed.ncbi.nlm.nih.gov/1314656

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Maleimido-based reagents for indirect, mild and specific radioiodolabeling of analogs of parathyroid hormone (PTH) and PTH-related protein

Autor: Michael Chorev, Michael P. Caulfield, Eliahu Roubini, Roberta L. McKee, Susan W. Gibbons, Jay J. Levy, Michael Rosenblatt

Publikováno v: Peptides ISBN: 9789401050050

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0eaeaac1412ffe2784a7e4d08aa1bb8a
https://doi.org/10.1007/978-94-011-2264-1_216

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Cyclic parathyroid hormone related protein antagonists: lysine 13 to aspartic acid 17 [i to (i + 4)] side chain to side chain lactamization

Autor: Susan W. Gibbons, Michael Chorev, Mark E. Goldman, Michael P. Caulfield, Eliahu Roubini, Roberta L. McKee, Michael Rosenblatt

Publikováno v: Biochemistry. 30(24)

Cyclization of parathyroid hormone related protein (7-34)amide [PTHrP(7-34)NH2] via covalent bond formation between the epsilon-amino of Lys13 and the beta-carboxyl of Asp17 yielded a 20-membered ring lactam. This analogue, [Lys13,Asp17]PTHrP(7-34)NH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a401448bfcc549163a4ee393aefae30f
https://pubmed.ncbi.nlm.nih.gov/1646005

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First highly potent cyclic parathyroid hormone-related peptide (PTHrP) antagonist

Autor: M. Rosenblatt, M. Chorev, Eliahu Roubini, S. W. Gibbons, Mark E. Goldman, Roberta L. McKee, M. P. Caulfield

Publikováno v: Peptides 1990 ISBN: 9789072199089
Peptides 1990

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5d1309301454c36ca6da60821b6853f
https://doi.org/10.1007/978-94-011-3034-9_305

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Effects of hydrophobic substitutions at position 18 on the potency of parathyroid hormone antagonists

Autor: Eliahu Roubini, Michael Chorev, Mark E. Goldman, Michael P. Caulfield, Jane E. Reagan, Roberta L. McKee, Susan W. Gibbons, Michael Rosenblatt

Publikováno v: International journal of peptide and protein research. 36(5)

Position 18 in a parathyroid hormone (PTH) antagonist, [Nle8,18,Tyr34]bPTH(7-34)NH2 (ii), was shown to tolerate substitutions by a range of amino acids with retention of inhibitory activity. The effects of hydrophobic substitutions at this position a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b559bcec80ef39887271971c9fb50ebc
https://pubmed.ncbi.nlm.nih.gov/2177456

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