Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Elia Smeir"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Treatment of multiple myeloma (MM) aims at inducing cell apoptosis by surpassing the limited capacity of MM cells to cope with oxidative stress. MM cell survival may further be suppressed by limiting cellular cholesterol. Long-chain fatty ac
Externí odkaz:
https://doaj.org/article/48da890086fd45d8856e963201073334
Autor:
David Lohr, Arne Thiele, Max Stahnke, Vera Braun, Elia Smeir, Joachim Spranger, Sebastian Brachs, Robert Klopfleisch, Anna Foryst-Ludwig, Laura M. Schreiber, Ulrich Kintscher, Niklas Beyhoff
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundObesity exerts multiple deleterious effects on the heart that may ultimately lead to cardiac failure. This study sought to characterize myocardial microstructure and function in an experimental model of obesity-related cardiac dysfunction.M
Externí odkaz:
https://doaj.org/article/f61a6287ebfa4d6b852632693ca330ce
Autor:
Elia Smeir, Sarah Leberer, Annelie Blumrich, Georg Vogler, Anastasia Vasiliades, Sandra Dresen, Carsten Jaeger, Yoann Gloaguen, Christian Klose, Dieter Beule, P. Christian Schulze, Rolf Bodmer, Anna Foryst-Ludwig, Ulrich Kintscher
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103314- (2021)
Summary: Cardiolipin (CL) is a major cardiac mitochondrial phospholipid maintaining regular mitochondrial morphology and function in cardiomyocytes. Cardiac CL production includes its biosynthesis and a CL remodeling process. Here we studied the impa
Externí odkaz:
https://doaj.org/article/495faf1d987c41ec8b93ea96ff9681f2
Autor:
Janek Salatzki, Anna Foryst-Ludwig, Kajetan Bentele, Annelie Blumrich, Elia Smeir, Zsofia Ban, Sarah Brix, Jana Grune, Niklas Beyhoff, Robert Klopfleisch, Sebastian Dunst, Michal A Surma, Christian Klose, Michael Rothe, Frank R Heinzel, Alexander Krannich, Erin E Kershaw, Dieter Beule, P Christian Schulze, Nikolaus Marx, Ulrich Kintscher
Publikováno v:
PLoS Genetics, Vol 14, Iss 1, p e1007171 (2018)
Adipose tissue lipolysis occurs during the development of heart failure as a consequence of chronic adrenergic stimulation. However, the impact of enhanced adipose triacylglycerol hydrolysis mediated by adipose triglyceride lipase (ATGL) on cardiac f
Externí odkaz:
https://doaj.org/article/ad8ab46f3d804bf2a9226a30b7313c13
Autor:
Jacob Bar-Tana, Eli Pikarsky, Martha Smets, Elia Smeir, Sarit Ohayon, Rachel Hertz, Udi Gluschnaider
Supplemental Figures S1-S3. c-Src/STAT3 crosstalk of Met-1 cells (S1); c-Src/STAT3 crosstalk of HCC1954 cells (S2); MEDICA amplifies radiation-suppressed clonogenity of HCC1954 cells (S3).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f0e80aa7b713a659dbc01744e2f079
https://doi.org/10.1158/0008-5472.22403924
https://doi.org/10.1158/0008-5472.22403924
Autor:
Jacob Bar-Tana, Eli Pikarsky, Martha Smets, Elia Smeir, Sarit Ohayon, Rachel Hertz, Udi Gluschnaider
Supplemental Figure Legends. Legends for Supplemental Figures S1-S3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4f3f3cd43350ffda5cf44a7260c5e1
https://doi.org/10.1158/0008-5472.22403927.v1
https://doi.org/10.1158/0008-5472.22403927.v1
Publikováno v:
Current Opinion in Pharmacology. 60:249-254
Cardiometabolic disorders, such as diabetes, obesity, or metabolic syndrome, are often considered as key comorbidities, leading to the development of different forms of cardiovascular diseases such as heart failure or diabetic cardiomyopathy. Althoug
Autor:
Ulrich Kintscher, Nicola Wilck, Arne Thiele, Hendrik Bartolomaeus, Anna Katharina Migglautsch, Elia Smeir, Robert Klopfleisch, Jana Grune, Michael Schupp, Katja Luettges, Michael Rothe, Rolf Breinbauer, Daniel Ritter, Erin E. Kershaw, Anna Foryst-Ludwig, Gernot F. Grabner, Niklas Beyhoff, Julia S. Steinhoff, Rudolf Zechner
Publikováno v:
Cardiovasc Res
Aims Heart failure (HF) is characterized by an overactivation of β-adrenergic signaling that directly contributes to impairment of myocardial function. Moreover, β-adrenergic overactivation induces adipose tissue lipolysis, which may further worsen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
Treatment of multiple myeloma (MM) aims at inducing cell apoptosis by surpassing the limited capacity of MM cells to cope with oxidative stress. MM cell survival may further be suppressed by limiting cellular cholesterol. Long-chain fatty acid analog
Publikováno v:
Oncotarget
B-Raf(V600E) activates MEK/MAPK signalling and acts as oncogenic driver of a variety of cancers, including melanoma, colorectal and papillary thyroid carcinoma. Specific B-Raf(V600E) kinase inhibitors (e.g., Vemurafenib) prove initial efficacy in mel