Hyperthermia as a Potential Cornerstone of Effective Multimodality Treatment with Radiotherapy, Cisplatin and PARP Inhibitor in IDH1-Mutated Cancer Cells

Autor: Mohammed Khurshed, Elia Prades-Sagarra, Sarah Saleh, Peter Sminia, Johanna W. Wilmink, Remco J. Molenaar, Hans Crezee, Cornelis J. F. van Noorden

Publikováno v: Cancers, 14(24):6228. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers; Volume 14; Issue 24; Pages: 6228
Khurshed, M, Prades-Sagarra, E, Saleh, S, Sminia, P, Wilmink, J W, Molenaar, R J, Crezee, H & van Noorden, C J F 2022, ' Hyperthermia as a Potential Cornerstone of Effective Multimodality Treatment with Radiotherapy, Cisplatin and PARP Inhibitor in IDH1-Mutated Cancer Cells ', Cancers, vol. 14, no. 24, 6228 . https://doi.org/10.3390/cancers14246228

Mutations in the isocitrate dehydrogenase 1 (IDH1MUT) gene occur in various types of malignancies, including ~60% of chondrosarcomas, ~30% of intrahepatic cholangiocarcinomas and >80% of low-grade gliomas. IDH1MUT are causal in the development and pr

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