Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Eli Wallace"'
A systems approach identifies Enhancer of Zeste Homolog 2 (EZH2) as a protective factor in epilepsy.
Autor:
Nadia Khan, Barry Schoenike, Trina Basu, Heidi Grabenstatter, Genesis Rodriguez, Caleb Sindic, Margaret Johnson, Eli Wallace, Rama Maganti, Raymond Dingledine, Avtar Roopra
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226733 (2019)
Complex neurological conditions can give rise to large scale transcriptomic changes that drive disease progression. It is likely that alterations in one or a few transcription factors or cofactors underlie these transcriptomic alterations. Identifyin
Externí odkaz:
https://doaj.org/article/7b16ff352c504ff69b9de432ae5aa2b8
Autor:
Eli Wallace, Kevin Koch, James D. Winkler, Patrice A. Lee, Joe Lyssikatos, Brian Hurley, Allison Marlow, Stefan Gross, Barbara J. Brandhuber, Darin Smith, Janet Parry, Ron J. Evans, Heidi Colwell, Josh Ballard, Bryan A. Bernat, Vivienne Marsh, Tammie C. Yeh
Supplementary Data, Yeh, et al. from Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb220f9585897004967629e2407f636
https://doi.org/10.1158/1078-0432.22441213.v1
https://doi.org/10.1158/1078-0432.22441213.v1
Autor:
Eli Wallace, Kevin Koch, James D. Winkler, Patrice A. Lee, Joe Lyssikatos, Brian Hurley, Allison Marlow, Stefan Gross, Barbara J. Brandhuber, Darin Smith, Janet Parry, Ron J. Evans, Heidi Colwell, Josh Ballard, Bryan A. Bernat, Vivienne Marsh, Tammie C. Yeh
Purpose: The Ras-Raf-mitogen-activated protein kinase kinase (MEK) pathway is overactive in many human cancers and is thus a target for novel therapeutics. We have developed a highly potent and selective inhibitor of MEK1/2. The purpose of these stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406a4a31b0cf89e0543cd3f66dfd4a9e
https://doi.org/10.1158/1078-0432.c.6518341.v1
https://doi.org/10.1158/1078-0432.c.6518341.v1
Autor:
Alok K. Sharma, Marcin Dyba, Dominic Esposito, Bin Wang, Pedro J. Beltran, Eli Wallace, Dwight Nissley, Frank McCormick, Anna E. Maciag
Publikováno v:
Molecular Cancer Research. 21:PR01-PR01
RAS mutations occur in approximately 20% of human cancers including the majority of pancreatic ductal adenocarcinoma (PDAC), half of colorectal cancers, and a third of all lung cancers. In cases of oncogenic activating RAS mutations, GTP hydrolysis i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c8dd271090ccee1f0dcc2488f1ba02e
https://doi.org/10.1158/1557-3125.ras23-pr01
https://doi.org/10.1158/1557-3125.ras23-pr01
Autor:
Jesse A. Pfammatter, Paulo Rodrigues, Rama Maganti, Sai Sruthi Konduru, Eli Wallace, Mathew V. Jones
Publikováno v:
Epilepsia Open
Epilepsia Open, Vol 6, Iss 1, Pp 181-194 (2021)
Epilepsia Open, Vol 6, Iss 1, Pp 181-194 (2021)
Study objectives Traumatic brain injury (TBI) results in sequelae that include posttraumatic epilepsy (PTE) and sleep‐wake disturbances. Here, we sought to determine whether sleep characteristics could predict development of PTE in a model of sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264a4a1f58edd0bb169e98cb23f28949
https://pubmed.ncbi.nlm.nih.gov/33681661
https://pubmed.ncbi.nlm.nih.gov/33681661
Autor:
Jesse A. Pfammatter, Mathew V. Jones, Paulo Rodrigues, Eli Wallace, Sai Sruthi Konduru, Rama Maganti
Study objectivesTraumatic brain injury (TBI) results in sequelae that include post-traumatic epilepsy (PTE) and sleep-wake disturbances. Here we sought to determine whether sleep characteristics could predict development of PTE in a model of severe T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30d2831c10b20948dc8410cae01b51ba
https://doi.org/10.1101/2020.06.16.137034
https://doi.org/10.1101/2020.06.16.137034
Autor:
Samantha Wright, Dylan J Douglas, Eli Wallace, Lauren I Steinberg, Mikolaj Filon, Rama Maganti, Carissa L Verkuilen, Cara J. Westmark, Pamela R. Westmark
Publikováno v:
Sleep
Study ObjectivesAccumulating evidence suggests a strong association between sleep, amyloid-beta (Aβ) deposition, and Alzheimer’s disease (AD). We sought to determine if: (1) deficits in rest-activity rhythms and sleep are significant phenotypes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea1976324587370fef25ab9cdd05e1b
Autor:
Antoine D. Madar, Erin I. Plumley, Bruce P. Hermann, Jesse A. Pfammatter, Michael Cowie, Mathew V. Jones, Jessica Bordenave, Rama Maganti, Eli Wallace, Swetha Ravi
Publikováno v:
J Neurosci
In temporal lobe epilepsy, the ability of the dentate gyrus to limit excitatory cortical input to the hippocampus breaks down, leading to seizures. The dentate gyrus is also thought to help discriminate between similar memories by performing pattern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f6b784772d08855b08aba3015eecc2
https://doi.org/10.1101/2020.02.13.948364
https://doi.org/10.1101/2020.02.13.948364
Autor:
James P. Stice, Sofia Donovan, Yuting Sun, Nancy Kohl, Barbara Czako, Faika Mseeh, Paul Leonard, Anna Wade, Justin Lim, Phil Jones, Eli Wallace, Kerstin Sinkevicius, Pedro Beltran
Publikováno v:
Molecular Cancer Therapeutics. 20:P207-P207
Src homology 2 domain-containing phosphatase (SHP2), a ubiquitously expressed non-receptor tyrosine phosphatase, plays a critical role in the regulation of the MAPK signaling pathway and cellular proliferation. Activating mutations in SHP2 are associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbd518f2371517aaa471c8cc35beac02
https://doi.org/10.1158/1535-7163.targ-21-p207
https://doi.org/10.1158/1535-7163.targ-21-p207
Autor:
Barry Schoenike, Heidi L. Grabenstatter, Trina Basu, Avtar Roopra, Nadia Khan, Eli Wallace, Raymond Dingledine, Genesis Rodriguez, Caleb Sindic, Rama Maganti, Margaret Johnson
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226733 (2019)
PLoS ONE
PLoS ONE
Complex neurological conditions can give rise to large scale transcriptomic changes that drive disease progression. It is likely that alterations in one or a few transcription factors or cofactors underlie these transcriptomic alterations. Identifyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e04a323b7adcbe8ad114b6441af443
https://doaj.org/article/7b16ff352c504ff69b9de432ae5aa2b8
https://doaj.org/article/7b16ff352c504ff69b9de432ae5aa2b8