Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Eli Schuman"'
Autor:
Tricia L. May-Dracka, Fang Gao, Brian T. Hopkins, Xiaoping Hronowski, TeYu Chen, Jayanth V. Chodaparambil, Claire M. Metrick, Mike Cullivan, Istvan Enyedy, Maciej Kaliszczak, Mark W. Kankel, Isaac Marx, Mackenzie A. Michell-Robinson, Param Murugan, P. Rajesh Kumar, Michael Rooney, Eli Schuman, Anindya Sen, Ti Wang, Tao Ye, Emily A. Peterson
Publikováno v:
ACS Med Chem Lett
[Image: see text] Phospholipase D (PLD) is a phospholipase enzyme responsible for hydrolyzing phosphatidylcholine into the lipid signaling molecule, phosphatidic acid, and choline. From a therapeutic perspective, PLD has been implicated in human canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe055bd69fb8ef7e48f9498480b28a32
https://europepmc.org/articles/PMC9014516/
https://europepmc.org/articles/PMC9014516/
Autor:
Kristopher W King, Brenda Amaral, Eli Schuman, LaiYee Wong, Michael Rooney, Marta Nevalainen, Jun Feng, Paramasivam Murugan, Jayanth V. Chodaparambil, Thomas A. Patterson, Hannah Certo, Martin K Himmelbauer, Rab Gilfillan, Tamara Halkina, Sarah Lamore, J Howard Jones, Douglas Marcotte, Gregory M Dillon, Jaclyn L. Henderson, Thomas Hesson, P Rajesh Kumar, Edward Yin-Shiang Lin, Channa Bao, Felix Gonzalez-Lopez de Turiso, Joshua L Johnson, Michael Calhoun
Publikováno v:
Journal of medicinal chemistry. 64(9)
Structural analysis of the known NIK inhibitor 3 bound to the kinase domain of TTBK1 led to the design and synthesis of a novel class of azaindazole TTBK1 inhibitors exemplified by 8 (cell IC50: 571 nM). Systematic optimization of this series of anal
Autor:
Ghotas Evindar, Frank T. Coppo, George P. Vlasuk, Eli Schuman, Charles A. Blum, Cheney Mao, Lei Jin, Han Dai, Robert B. Perni, Jianghe Deng, Svetlana L. Belyanskaya, Todd L. Graybill, John W. Cuozzo, Leah Aquilani, Jeremy S. Disch, Cynthia H. Chiu, Siva Lavu, Kenneth E Lind
Publikováno v:
Journal of Medicinal Chemistry. 56:3666-3679
The sirtuins SIRT1, SIRT2, and SIRT3 are NAD(+) dependent deacetylases that are considered potential targets for metabolic, inflammatory, oncologic, and neurodegenerative disorders. Encoded library technology (ELT) was used to affinity screen a 1.2 m
Autor:
Lewis C. Cantley, Jun Xian, Heather R. Christofk, Edward E. Harlow, Alexander O. Subtelny, Eli Schuman, Matthew G. Vander Heiden, Hadar Sharfi
Publikováno v:
Biochemical Pharmacology. 79:1118-1124
A common feature of tumors arising from diverse tissue types is a reliance on aerobic glycolysis for glucose metabolism. This metabolic difference between cancer cells and normal cells could be exploited for therapeutic benefit in patients. Cancer ce
Autor:
Joel Moss, Sean M. Armour, Huizhen Zhao, Alvin J. Y. Ling, Charles A. Blum, Yoshitomo Hamuro, Konrad T. Howitz, George P. Vlasuk, Jeremy S. Disch, Bradley L. Pentelute, Jessica E. Lee, Dudley W. Lamming, Ana P. Gomes, James L. Ellis, Shaday Michan, Anabela P. Rolo, Sharon Sweitzer, David A. Sinclair, Thomas Considine, Robert B. Perni, Pui Yee Ng, Sook Yen E, April Case, Eli Schuman, Thomas V. Riera, Basil P. Hubbard, Yong Jiang, Linda A. Stevens, Han Dai, Jun Li
Publikováno v:
PMC
A molecule that treats multiple age-related diseases would have a major impact on global health and economics. The SIRT1 deacetylase has drawn attention in this regard as a target for drug design. Yet controversy exists around the mechanism of sirtui