Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Eli R. Schuman"'
Autor:
Alexandra D. Zaitsev, Marcie A. Glicksman, Ross L. Stein, Brittany Dobson, Ken Auerbach, Zhenyu Yue, Min Liu, Kathleen Seyb, Shibu M. Poulose, Eli R. Schuman, Gregory D. Cuny
Publikováno v:
Analytical Biochemistry. 404:186-192
LRRK2 is a large and complex protein that possesses kinase and GTPase activities and has emerged as the most relevant player in PD pathogenesis possibly through a toxic gain-of-function mechanism. Kinase activity is a critical component of LRRK2 func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1355d152d1ee8eb13257db35da4c0ab
https://doi.org/10.1016/j.ab.2010.05.033
https://doi.org/10.1016/j.ab.2010.05.033
Autor:
Eli R. Schuman, Marcie A. Glicksman, Jake Ni, William F. Crowley, Maria Burnett, Ursula B. Kaiser, Wendy Kuohung, Deepa Mukhtyar
Publikováno v:
SLAS Discovery. 15:508-517
Recent data have shown that the G-protein-coupled receptor GPR54 (also known as KiSS-1 receptor) regulates GnRH release from the hypothalamus. This essential role of GPR54 in controlling the hypothalamic-pituitary-gonadal axis makes it an attractive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb63d7e1c94fe180add4b3d8d47d8fc5
https://doi.org/10.1177/1087057110369701
https://doi.org/10.1177/1087057110369701
Publikováno v:
SLAS Discovery. 13:870-878
Calpain activation is hypothesized to be an early occurrence in the sequence of events resulting in neurodegeneration, as well as in the signaling pathways linking extracellular accumulation of Aβ peptides and intracellular formation of neurofibrill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e48333d23e7d8c0e57ea8c41ef10e9
https://doi.org/10.1177/1087057108323909
https://doi.org/10.1177/1087057108323909
Autor:
Haining Zhu, Kathleen Seyb, Xiaohu Tang, Ping Shi, Eli R. Schuman, Mickey Huang, Marcie A. Glicksman
Aberrant protein-protein interactions are attractive drug targets in a variety of neurodegenerative diseases due to the common pathology of accumulation of protein aggregates. In amyotrophic lateral sclerosis, mutations in SOD1 cause the formation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15bc2fb021a43aea64563f651f0c0dbc
https://europepmc.org/articles/PMC3580275/
https://europepmc.org/articles/PMC3580275/
Autor:
Ci-Di Chen, Patricia L. Brazee, Eli R. Schuman, Carmela R. Abraham, Gregory D. Cuny, Gwendalyn D. King, Ella Zeldich, Maxime Robin, Mickey Huang, Marcie A. Glicksman
Publikováno v:
The Biochemical journal. 441(1)
The absence of Klotho (KL) from mice causes the development of disorders associated with human aging and decreased longevity, whereas increased expression prolongs lifespan. With age, KL protein levels decrease, and keeping levels consistent may prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c26dd184131ef65519381e279c9d08
https://pubmed.ncbi.nlm.nih.gov/21939436
https://pubmed.ncbi.nlm.nih.gov/21939436
Autor:
Gwendalyn D. King, CiDi Chen, Mickey M. Huang, Ella Zeldich, Patricia L. Brazee, Eli R. Schuman, Maxime Robin, Gregory D. Cuny, Marcie A. Glicksman, Carmela R. Abraham
Publikováno v:
Biochemical Journal; Jan2012, Vol. 441 Issue 1, p453-461, 9p