Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Eli J Dugan"'
Autor:
Mira D. Liu, David F. Savage, Thomas G. Laughlin, Cecilia Blikstad, Sophie R. Shoemaker, Jonathan P Remis, Eli J Dugan
Carboxysomes are proteinaceous organelles that encapsulate key enzymes of CO2fixation - Rubisco and carbonic anhydrase - and are the centerpiece of the bacterial CO2concentrating mechanism (CCM). In the CCM, actively accumulated cytosolic bicarbonate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0c4f26c24e7c82f2c9527f92b59ad89
https://doi.org/10.1101/2021.11.05.467472
https://doi.org/10.1101/2021.11.05.467472
Autor:
Chunyu Zhao, Abdul Bhuiya, Jennifer A. Doudna, Melanie Ott, Emeric J Charles, Ming X. Tan, Brittney W. Thornton, Patrick D. Hsu, Amanda Mok, Arturo M. Escajeda, María Díaz de León Derby, Katherine S. Pollard, Daniel A. Fletcher, David F. Savage, G. Renuka Kumar, Noam Prywes, Tina Y. Liu, Dylan C. J. Smock, Shineui Kim, John J Desmarais, Eli J Dugan, Parinaz Fozouni, Sungmin Son, Liana F. Lareau, Neil A. Switz, Andrew R. Harris, Stephanie I. Stephens, Maxim Armstrong, Jeffrey Shu, Shrutee Jakhanwal, Anthony T. Iavarone, Roger McIntosh, Shreeya Agrawal, Gavin J. Knott
Publikováno v:
Nat Chem Biol
Nature Chemical Biology
medRxiv
article-version (status) pre
article-version (number) 1
Nature Chemical Biology
medRxiv
article-version (status) pre
article-version (number) 1
Direct, amplification-free detection of RNA has the potential to transform molecular diagnostics by enabling simple on-site analysis of human or environmental samples. CRISPR-Cas nucleases offer programmable RNA-guided RNA recognition that triggers c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c785d1b2d3e9f64e47f040660076a9bd
https://europepmc.org/articles/PMC10184463/
https://europepmc.org/articles/PMC10184463/
Autor:
Ziyang Zhang, Peter J. Rohweder, Chayanid Ongpipattanakul, Koli Basu, Markus-Frederik Bohn, Eli J. Dugan, Veronica Steri, Byron Hann, Kevan M. Shokat, Charles S. Craik
Publikováno v:
Zhang, Z, Rohweder, P J, Ongpipattanakul, C, Basu, K, Bohn, M-F, Dugan, E J, Steri, V, Hann, B, Shokat, K M & Craik, C S 2022, ' A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy ', Cancer Cell, vol. 40, no. 9, pp. 1060-1069.e7 . https://doi.org/10.1016/j.ccell.2022.07.005
Immunotargeting of tumor-specific antigens is a powerful therapeutic strategy. Immunotherapies directed at MHC-I complexes have expanded the scope of antigens and enabled the direct targeting of intracellular oncoproteins at the cell surface. We aske
Autor:
Alison Fanton, Arturo M. Escajeda, Qi Dang, Sarah A. Stanley, Scott B. Biering, Jennifer A. Doudna, Maria Lukarska, David F. Savage, Shreeya Agrawal, Sita S. Chandrasekaran, Tina Y. Liu, Shin Kim, Dylan C. J. Smock, Gavin J. Knott, Ming X. Tan, Eli J Dugan, Eva Harris, Maxim Armstrong, María Díaz de León Derby, Patrick D. Hsu, Bérénice Charrez, Abdul Bhuiya, Daniel A. Fletcher, Noam Prywes, Andrew R. Harris, Roger McIntosh, Neil A. Switz, Sungmin Son, Amanda Mok, Erik Van Dis, Liana F. Lareau
SummaryRapid nucleic acid testing is a critical component of a robust infrastructure for increased disease surveillance. Here, we report a microfluidic platform for point-of-care, CRISPR-based molecular diagnostics. We first developed a nucleic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e1f77d8169d1823e572832e48428314
https://doi.org/10.1101/2020.12.14.20247874
https://doi.org/10.1101/2020.12.14.20247874
Autor:
David F. Savage, Shira Amram, Cecilia Blikstad, Ron Milo, Arren Bar-Even, Avi I. Flamholz, Eli J Dugan, Shmuel Gleizer, Niv Antonovsky, Sumedha Ravishankar, Elad Noor, Roee Ben-Nissan
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Many photosynthetic organisms employ a CO2concentrating mechanism (CCM) to increase the rate of CO2fixation via the Calvin cycle. CCMs catalyze ≈50% of global photosynthesis, yet it remains unclear which genes and proteins are required to produce t
Autor:
Cecilia Blikstad, Niv Antonovsky, Shmuel Gleizer, Eli J Dugan, Roee Ben-Nissan, Ron Milo, Arren Bar-Even, David F. Savage, Elad Noor, Avi I. Flamholz, Shira Amram, Sumedha Ravishankar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb5d01b57edeceaec8ed797f7e297d21
https://doi.org/10.7554/elife.59882.sa2
https://doi.org/10.7554/elife.59882.sa2
Autor:
Avi I. Flamholz, David F. Savage, Roee Ben-Nissan, Shmuel Gleizer, Ron Milo, Cecilia Blikstad, Shira Amram, Sumedha Ravishankar, Niv Antonovsky, Elad Noor, Arren Bar-Even, Eli J Dugan
Many photosynthetic organisms employ a CO2concentrating mechanism (CCM) to increase the rate of CO2fixation via the Calvin cycle. CCMs catalyze ≈50% of global photosynthesis, yet it remains unclear which genes and proteins are required to produce t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::287f5910d20687fd4d68a57ba9cad124
https://doi.org/10.1101/2020.05.27.119784
https://doi.org/10.1101/2020.05.27.119784
Autor:
Thomas G. Laughlin, John J Desmarais, Joy Y. Wang, Allen W. Chen, Avi I. Flamholz, Kelly M. Wetmore, Luke M. Oltrogge, Spencer Diamond, Eli J Dugan, Cecilia Blikstad, David F. Savage
Publikováno v:
Nature microbiology, vol 4, iss 12
Nat Microbiol
Nat Microbiol
Bacterial autotrophs often rely on CO2 concentrating mechanisms (CCMs) to assimilate carbon. Although many CCM proteins have been identified, a systematic screen of the components of CCMs is lacking. Here, we performed a genome-wide barcoded transpos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6741af8ff6acae75b17a234bc1911f
https://escholarship.org/uc/item/31j2806m
https://escholarship.org/uc/item/31j2806m
Autor:
Amanda Mok, G. Renuka Kumar, Eli J Dugan, Noam Prywes, Stephanie I. Stephens, Shreeya Agrawal, María Díaz de León Derby, Liana F. Lareau, John J Desmarais, Brittney W. Thornton, David F. Savage, Andrew R. Harris, Katherine S. Pollard, Roger McIntosh, Patrick D. Hsu, Abdul Bhuiya, Emeric J Charles, Gavin J. Knott, Parinaz Fozouni, Anthony T. Iavarone, Melanie Ott, Shineui Kim, Sungmin Son, Ming X. Tan, Tina Y. Liu, Neil A. Switz, Chunyu Zhao, Shrutee Jakhanwal, Arturo M. Escajeda, Maxim Armstrong, Jeffrey Shu, Dylan C. J. Smock, Jennifer A. Doudna, Daniel A. Fletcher
Publikováno v:
Nature Chemical Biology. 17:1210-1210
Autor:
Aochiu Chen, Avi I. Flamholz, Cecilia Blikstad, Kelly M. Wetmore, Luke M. Oltrogge, John J Desmarais, Eli J Dugan, Spencer Diamond, J. Wang, Thomas G. Laughlin, David F. Savage
Many bacterial autotrophs rely on CO2concentrating mechanisms (CCMs) to assimilate carbon. Although many CCM proteins have been identified, including a 200+ MDa protein organelle called the carboxysome, a systematic screen of CCM components has not b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a27ddda1556dd4cb779f24f17795f15