Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Eli Fritz McDonald"'
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0297560 (2024)
Variants in the cystic fibrosis transmembrane conductance regulator gene (CFTR) result in cystic fibrosis-a lethal autosomal recessive disorder. Missense variants that alter a single amino acid in the CFTR protein are among the most common cystic fib
Externí odkaz:
https://doaj.org/article/d9b8d3609c484310a0dc18ddebc2180b
Autor:
Eli Fritz McDonald, Hope Woods, Shannon T. Smith, Minsoo Kim, Clara T. Schoeder, Lars Plate, Jens Meiler
Publikováno v:
Biomolecules, Vol 12, Iss 3, p 471 (2022)
Cystic fibrosis (CF) is a rare genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), an epithelial anion channel expressed in several vital organs. Absence of functional CFTR results in imbalanced osmo
Externí odkaz:
https://doaj.org/article/1714a81650424879aa472f0f4712ffcc
Autor:
Jazlyn A. Selvasingh, Eli Fritz McDonald, Jacob R. Mckinney, Jens Meiler, Kaitlyn V. Ledwitch
Measuring protein thermostability provides valuable information on the biophysical rules that govern structure-energy relationships of proteins. However, such measurements remain a challenge for membrane proteins. Here, we introduce a new experimenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7d4da46e9189284e6b8ec7342ea8a1a
https://doi.org/10.1101/2023.05.08.539917
https://doi.org/10.1101/2023.05.08.539917
Autor:
Georg Kuenze, Amanda M Duran, Hope Woods, Kathryn R Brewer, Eli Fritz McDonald, Carlos G Vanoye, Alfred L George, Charles R Sanders, Jens Meiler
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0220415 (2019)
The voltage-gated potassium channel KCNQ1 (KV7.1) assembles with the KCNE1 accessory protein to generate the slow delayed rectifier current, IKS, which is critical for membrane repolarization as part of the cardiac action potential. Loss-of-function
Externí odkaz:
https://doaj.org/article/34428767e7f74f1ab409652801eb3dd6
Autor:
Minsoo Kim, Eli Fritz McDonald, Carleen Mae P. Sabusap, Bibek Timalsina, Disha Joshi, Jeong S. Hong, Andras Rab, Eric J. Sorscher, Lars Plate
Cystic fibrosis (CF) is one of the most prevalent lethal genetic diseases with over 2000 identified mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Pharmacological chaperones such as Lumacaftor (VX-809), Tezacaftor (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20aff35d966b885857a7dc91c14c4000
https://doi.org/10.1101/2023.02.04.527134
https://doi.org/10.1101/2023.02.04.527134
Publikováno v:
Molecular Biology of the Cell. 33
Pharmacological chaperones represent a class of therapeutic compounds for treating protein misfolding diseases. One of the most prominent examples is the FDA-approved pharmacological chaperone lumacaftor (VX-809), which has transformed cystic fibrosi
Publikováno v:
ACS Infectious Diseases
bioRxiv
article-version (status) pre
article-version (number) 1
bioRxiv
article-version (status) pre
article-version (number) 1
Human coronaviruses (hCoV) have become a threat to global health and society, as evident from the SARS outbreak in 2002 caused by SARS-CoV-1 and the most recent COVID-19 pandemic caused by SARS-CoV-2. Despite high sequence similarity between SARS-CoV
Publikováno v:
Structure (London, England : 1993). 31(1)
Recent advancements in computational tools have allowed protein structure prediction with high accuracy. Computational prediction methods have been used for modeling many soluble and membrane proteins, but the performance of these methods in modeling
Autor:
Minsoo Kim, Lars Plate, Eli Fritz McDonald, Shannon T. Smith, Jens Meiler, Hope Woods, Clara T. Schoeder
Cystic Fibrosis (CF) is a common genetic disease caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), an epithelial anion channel expressed in several vital organs. Absence of functional CFTR results in imbalanced os
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::448da26036503f9e0600f7739caf79b4
https://doi.org/10.1101/2021.11.17.468921
https://doi.org/10.1101/2021.11.17.468921
Autor:
Sneha Adusumilli, Hope Woods, Charles R. Sanders, Jens Meiler, Georg Kuenze, Carlos G. Vanoye, Reshma R. Desai, Eli Fritz McDonald, Alfred G. George, Kathryn R. Brewer
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
The function of the voltage-gated KCNQ1 potassium channel is regulated by co-assembly with KCNE auxiliary subunits. KCNQ1-KCNE1 channels generate the slow delayed rectifier current, IKs, which contributes to the repolarization phase of the cardiac ac