Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Eli C. Lewis"'
Autor:
Ido Brami, Tsila Zuckerman, Ron Ram, Batia Avni, Galit Peretz, Daniel Ostrovsky, Yotam Lior, Caroline Faour, Oisin McElvaney, Noel G. McElvaney, Eli C. Lewis
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 422 (2023)
α1-Antitrypsin (AAT), an acute-phase reactant not unsimilar to C-reactive protein (CRP), is a serine protease inhibitor that harbors tissue-protective and immunomodulatory attributes. Its concentrations appropriately increase during conditions of ex
Externí odkaz:
https://doaj.org/article/06a97daf5c92472e935ac2178e4a0801
Publikováno v:
Applied Sciences, Vol 12, Iss 18, p 9359 (2022)
Protecting tissues from excessive inflammation by glucocorticoids results in an effective blockade of inflammation; however, it does not instigate processes of inflammatory resolution or tissue repair. Moreover, glucocorticoids have side effects such
Externí odkaz:
https://doaj.org/article/66db8a9cfc824f70abcfc16826f0a2ed
Autor:
Alon Gimmon, Lior Sherker, Lena Kojukarov, Melodie Zaknoun, Yotam Lior, Tova Fadel, Ronen Schuster, Eli C. Lewis, Eldad Silberstein
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7364 (2022)
Wound healing requires a non-compromising combination of inflammatory and anti-inflammatory processes. Human α1-antitrypsin (hAAT), a circulating glycoprotein that rises during acute-phase responses and during healthy pregnancies, is tissue-protecti
Externí odkaz:
https://doaj.org/article/6e0d41351a664ed0a8517c5dadd8b8d0
Autor:
Ziv Kaner, Rotem Engelman, Ronen Schuster, Peleg Rider, David Greenberg, Yossef Av-Gay, Moran Benhar, Eli C. Lewis
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background: Human α1-antitrypsin (hAAT) is a circulating anti-inflammatory serine-protease inhibitor that rises during acute phase responses. in vivo, hAAT reduces bacterial load, without directly inhibiting bacterial growth. In conditions of excess
Externí odkaz:
https://doaj.org/article/3d9bd825ade54ac09780d1d4b599b443
Autor:
Marco A. Sutter, Tiziana P. Cremona, Izabela Nita, Eleonora Cavarra, Giuseppe Lungarella, Eli C. Lewis, Johannes C. Schittny, Thomas Geiser, Amiq Gazdhar
Publikováno v:
Pharmaceutics, Vol 12, Iss 9, p 793 (2020)
Rationale: Mutation in the alpha1 antitrypsin (AAT) gene leads to low circulating levels of AAT, which is associated with several disease processes including pulmonary emphysema. The standard of care relies on substitution with plasma-purified AAT. W
Externí odkaz:
https://doaj.org/article/7e02e3d291bc4b8e8e09e6a0b265e311
Autor:
Yotam Lior, Mariana Zaretsky, David E. Ochayon, Diana Lotysh, Boris M. Baranovski, Ronen Schuster, Ofer Guttman, Amir Aharoni, Eli C. Lewis
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
IntroductionHuman α1-antitrypsin (hAAT) is a 394-amino acid long anti-inflammatory, neutrophil elastase inhibitor, which binds elastase via a sequence-specific molecular protrusion (reactive center loop, RCL; positions 357–366). hAAT formulations
Externí odkaz:
https://doaj.org/article/485d78fe6906435d902fe3ccf61c2442
Autor:
Ariel Sobarzo, Yael Eskira, Andrew S. Herbert, Ana I. Kuehne, Spencer W. Stonier, David E. Ochayon, Shlomit Fedida-Metula, Steven Balinandi, Yaara Kislev, Neta Tali, Eli C. Lewis, Julius Julian Lutwama, John M. Dye, Victoria Yavelsky, Leslie Lobel
Publikováno v:
Viruses, Vol 7, Iss 1, Pp 37-51 (2015)
Recovery from ebolavirus infection in humans is associated with the development of both cell-mediated and humoral immune responses. According to recent studies, individuals that did not survive infection with ebolaviruses appear to have lacked a robu
Externí odkaz:
https://doaj.org/article/e07c7302308e4c59ba15db0a749dc146
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
α1-antitrypsin (AAT), a circulating glycoprotein that rises during acute phase responses and healthy pregnancies, exhibits immunomodulatory properties in several T-cell–dependent immune pathologies. However, AAT does not interfere with isolated T-
Externí odkaz:
https://doaj.org/article/424d9020d321405794983a8a30fd8d72
Autor:
David E. Ochayon, Boris M. Baranovski, Peter Malkin, Ronen Schuster, Noa Kalay, Rotem Ben-Hamo, Ido Sloma, Justin Levinson, Jared Brazg, Sol Efroni, Eli C. Lewis, Uri Nevo
Publikováno v:
Cell Transplantation, Vol 25 (2016)
Immune tolerance toward “self” is critical in multiple immune disorders. While there are several mechanisms to describe the involvement of immune cells in the process, the role of peripheral tissue cells in that context is not yet clear. The theo
Externí odkaz:
https://doaj.org/article/8c074e7b554446628cf5b9dae397d835
Publikováno v:
Cell Transplantation, Vol 22 (2013)
Pancreatic islets are a highly vascularized entity, and their transplantation into diabetic individuals requires optimal revascularization. In addition, β-cells in islets are extremely sensitive to inflammation. α-1-Antitrypsin (AAT), a circulating
Externí odkaz:
https://doaj.org/article/4eb58508c0a64ecd8b422452742a818c