Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Eli Akude"'
Autor:
Elena Zherebitskaya, Jason Schapansky, Eli Akude, Darrell R Smith, Randy Van der Ploeg, Natasha Solovyova, Alexei Verkhratsky, Paul Fernyhough
Publikováno v:
ASN Neuro, Vol 4 (2011)
Distal symmetrical sensory neuropathy in diabetes involves the dying back of axons, and the pathology equates with axonal dystrophy generated under conditions of aberrant Ca 2+ signalling. Previous work has described abnormalities in Ca 2+ homoeostas
Externí odkaz:
https://doaj.org/article/f082142f950145fd9bb5f4bdade76ad6
Autor:
Ali Saleh, Subir K. Roy Chowdhury, Suzanne Gomes, Jason Schapansky, Nigel A. Calcutt, Darrell R. Smith, Dwane Morrow, Eli Akude, Alexandra Marquez, Paul Fernyhough
Publikováno v:
Brain. 135:1751-1766
Mitochondrial dysfunction occurs in sensory neurons and may contribute to distal axonopathy in animal models of diabetic neuropathy. The adenosine monophosphate-activated protein kinase and peroxisome proliferator-activated receptor γ coactivator-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ecdcae619b2abac6062328b72736e63
https://doi.org/10.1093/brain/aws097
https://doi.org/10.1093/brain/aws097
Autor:
Darrell R. Smith, Paul Fernyhough, Rick T. Dobrowsky, Subir K. Roy Chowdhury, Elena Zherebitskaya, Eli Akude
Publikováno v:
Diabetes
OBJECTIVE Impairments in mitochondrial function have been proposed to play a role in the etiology of diabetic sensory neuropathy. We tested the hypothesis that mitochondrial dysfunction in axons of sensory neurons in type 1 diabetes is due to abnorma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d869e234cbf044e1d63ee60814ecc2a0
http://europepmc.org/articles/PMC3012184
http://europepmc.org/articles/PMC3012184
Publikováno v:
Diabetes. 58:1356-1364
OBJECTIVE Reactive oxygen species (ROS) are pro-oxidant factors in distal neurodegeneration in diabetes. We tested the hypothesis that sensory neurons exposed to type 1 diabetes would exhibit enhanced ROS and oxidative stress and determined whether t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::811de4b335e1621bebef2339cc1e49cc
https://doi.org/10.2337/db09-0034
https://doi.org/10.2337/db09-0034
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(26)
Synapses in autonomic ganglia represent the final output of various CNS structures that regulate the function of the periphery. Normally, these excitatory cholinergic-nicotinic synapses produce large suprathreshold EPSPs on sympathetic and parasympat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c6ada2984ef5b2215697bc205626fa
https://pubmed.ncbi.nlm.nih.gov/24966386
https://pubmed.ncbi.nlm.nih.gov/24966386
Autor:
Nigel A. Calcutt, Dwane Morrow, Paul Fernyhough, Eli Akude, Subir K. Roy Chowdhury, Ali Saleh, Lori Tessler, Darrell R. Smith
Publikováno v:
Cellular and molecular neurobiology. 34(5)
Mitochondrial dysfunction occurs in sensory neurons and contributes to diabetic neuropathy. Ciliary neurotrophic factor (CNTF) stimulates axon regeneration in type 1 diabetic rodents and prevents deficits in axonal caliber, nerve conduction, and ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e20fd53e34e27e720b4bfeaa5417f0
https://pubmed.ncbi.nlm.nih.gov/24682898
https://pubmed.ncbi.nlm.nih.gov/24682898
Autor:
Eli Akude, Paul Fernyhough, Corinne G. Jolivalt, Sharmila Chattopadhyay, Elena Zherebitskaya, Nigel A. Calcutt, Subir K. Roy Chowdhury, Darrell R. Smith
Publikováno v:
Diabetes
OBJECTIVE Impairments in mitochondrial physiology may play a role in diabetic sensory neuropathy. We tested the hypothesis that mitochondrial dysfunction in sensory neurons is due to abnormal mitochondrial respiratory function. RESEARCH DESIGN AND ME
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248b002fc6108bdce70d495dd462913d
https://pubmed.ncbi.nlm.nih.gov/20103706
https://pubmed.ncbi.nlm.nih.gov/20103706
Publikováno v:
Neurotoxicity research. 17(1)
Modification of proteins by 4-hydroxy-2-nonenal (4-HNE) has been proposed to cause neurotoxicity in a number of neurodegenerative diseases, including distal axonopathy in diabetic sensory neuropathy. We tested the hypothesis that exposure of cultured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30063c7e58be4bdac1e9888db35bec60
https://pubmed.ncbi.nlm.nih.gov/19557324
https://pubmed.ncbi.nlm.nih.gov/19557324
Autor:
Alexei Verkhratsky, Randy Van der Ploeg, Paul Fernyhough, Jason Schapansky, Elena Zherebitskaya, Darrell R. Smith, Natasha Solovyova, Eli Akude
Publikováno v:
Scopus-Elsevier
ASN NEURO
ASN NEURO
Distal symmetrical sensory neuropathy in diabetes involves the dying back of axons, and the pathology equates with axonal dystrophy generated under conditions of aberrant Ca2+ signalling. Previous work has described abnormalities in Ca2+ homoeostasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef9c341404d604b91006d48fe10ffd1
http://www.scopus.com/inward/record.url?eid=2-s2.0-84864003480&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-84864003480&partnerID=MN8TOARS
Autor:
Paul Fernyhough, Eli Akude, Rick T. Dobrowsky, Darrell R. Smith, Elena Zherebitskaya, Subir K. Roy Chowdhury
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. :76
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b5e1952715e9973dd8258f0ad4d01f