Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Eli Rothenberg"'
Autor:
Liana Goehring, Sarah Keegan, Sudipta Lahiri, Wenxin Xia, Michael Kong, Judit Jimenez-Sainz, Dipika Gupta, Ronny Drapkin, Ryan B. Jensen, Duncan J. Smith, Eli Rothenberg, David Fenyö, Tony T. Huang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract BRCA2 is a tumor suppressor protein responsible for safeguarding the cellular genome from replication stress and genotoxicity, but the specific mechanism(s) by which this is achieved to prevent early oncogenesis remains unclear. Here, we pro
Externí odkaz:
https://doaj.org/article/6eae7c91ca5e4e60a5079c4501597601
Autor:
Aina Maria Mas, Enrique Goñi, Igor Ruiz de los Mozos, Aida Arcas, Luisa Statello, Jovanna González, Lorea Blázquez, Wei Ting Chelsea Lee, Dipika Gupta, Álvaro Sejas, Shoko Hoshina, Alexandros Armaos, Gian Gaetano Tartaglia, Shou Waga, Jernej Ule, Eli Rothenberg, María Gómez, Maite Huarte
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Cells must coordinate the activation of thousands of replication origins dispersed throughout their genome. Active transcription is known to favor the formation of mammalian origins, although the role that RNA plays in this process remains u
Externí odkaz:
https://doaj.org/article/b3707f40fa664ce89cc857b4fe225cb8
Autor:
Sameera Vipat, Dipika Gupta, Sagun Jonchhe, Hele Anderspuk, Eli Rothenberg, Tatiana N. Moiseeva
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
DNA polymerase epsilon has a critical role in DNA replication initiation. Here, the authors show that in human cancer cells POLE is dispensable for the replicative helicase assembly but not for replication initiation, which requires the non-catalytic
Externí odkaz:
https://doaj.org/article/e374e13487da4baf92fe559ec9fff4dd
Autor:
Kate E. Coleman, Yandong Yin, Sarah Kit Leng Lui, Sarah Keegan, David Fenyo, Duncan J. Smith, Eli Rothenberg, Tony T. Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Here the authors provide mechanistic insights into how auto-cleavage of the USP1 deubiquitinase regulates DNA replication and genome stability. Implications for the targeting of USP1 activity via protein-DNA trapping in cancer therapy are discussed.
Externí odkaz:
https://doaj.org/article/000e432cb2774ebca453ed5d0d729f67
Autor:
Judit Jimenez-Sainz, Joshua Mathew, Gemma Moore, Sudipta Lahiri, Jennifer Garbarino, Joseph P Eder, Eli Rothenberg, Ryan B Jensen
Publikováno v:
eLife, Vol 11 (2022)
Pathogenic mutations in the BRCA2 tumor suppressor gene predispose to breast, ovarian, pancreatic, prostate, and other cancers. BRCA2 maintains genome stability through homology-directed repair (HDR) of DNA double-strand breaks (DSBs) and replication
Externí odkaz:
https://doaj.org/article/eee52955fae0447b99212376c3441014
Autor:
Wei Ting C. Lee, Yandong Yin, Michael J. Morten, Peter Tonzi, Pam Pam Gwo, Diana C. Odermatt, Mauro Modesti, Sharon B. Cantor, Kerstin Gari, Tony T. Huang, Eli Rothenberg
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
In the genome, repetitive guanine-rich sequences have the potential to spontaneously fold into non-canonical DNA secondary structures known as G-quadruplex (G4). Using novel single-molecule imaging approaches, the authors reveal that G4 formation wit
Externí odkaz:
https://doaj.org/article/6a1841de8fd7414d95ee7b037e0668ec
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
V(D)J recombination is an essential mechanism of the adaptive immune system, producing a diverse set of antigen receptors in developing lymphocytes via regulated double strand DNA break and subsequent repair. DNA cleavage is initiated by the recombin
Externí odkaz:
https://doaj.org/article/a0c06117416c44109451e262c57a4970
Autor:
Bailin Zhao, Go Watanabe, Michael J. Morten, Dylan A. Reid, Eli Rothenberg, Michael R. Lieber
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
During a process termed synapsis, the two DNA ends at a double-strand break (DSB) are brought together into physical proximity. Here, the authors use a single-molecule FRET approach with purified proteins to investigate the mechanism of synapsis in D
Externí odkaz:
https://doaj.org/article/8ea44050cb614a2e9f26069961a8fcee
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
Analyzing the organization of molecular complexes in multi-color single-molecule localization microscopy data requires heavy computation resources that are impractical for laboratory computers. Here the authors develop a coordinate-based Triple-Corre
Externí odkaz:
https://doaj.org/article/bbb34acb11294718a24f1e868e239844
Autor:
Hannah L Klein, Kenny K.H. Ang, Michelle R. Arkin, Emily C. Beckwitt, Yi-Hsuan Chang, Jun Fan, Youngho Kwon, Michael J. Morten, Sucheta Mukherjee, Oliver J. Pambos, Hafez el Sayyed, Elizabeth S. Thrall, João P. Vieira-da-Rocha, Quan Wang, Shuang Wang, Hsin-Yi Yeh, Julie S. Biteen, Peter Chi, Wolf-Dietrich Heyer, Achillefs N. Kapanidis, Joseph J. Loparo, Terence R. Strick, Patrick Sung, Bennett Van Houten, Hengyao Niu, Eli Rothenberg
Publikováno v:
Microbial Cell, Vol 6, Iss 1, Pp 65-101 (2019)
Genomes are constantly in flux, undergoing changes due to recombination, repair and mutagenesis. In vivo, many of such changes are studies using reporters for specific types of changes, or through cytological studies that detect changes at the single
Externí odkaz:
https://doaj.org/article/284d1fa54b1b42a89ebab92b52616ba5