Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Eliška Procházková"'
Delivery of N-heterocyclic drugs, acids, phenols, and thiols via Tailor−made Self−immolative linkers
Autor:
Vahid Barati, Anna Hruzíková, Eliška Procházková, Martin Zavřel, Jaroslav Kozák, Jana Trylčová, Dominik Rejman, Jan Weber, Kateřina Bogdanová, Milan Kolář, Ondřej Baszczyňski
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 12, Iss , Pp 100216- (2024)
Heterocyclic drugs display diverse pharmacological activities and metabolic stability. However, their poor solubility and pharmacokinetic properties often compromise bioavailability and clinical outcomes. Nevertheless, the prodrug approach provides a
Externí odkaz:
https://doaj.org/article/02da55a35360455dbc11c50a0c3d790f
Autor:
Adam Čepa, Veronika Dejmková, Ladislav Lešetický, Ivan Jelínek, Stanislav Smrček, Martin Štícha, Jana Jašprová, Marie Urbanová, Iryna Goncharova, Martin Dračínský, Eliška Procházková, Donald J. Ostrow, Libor Vítek
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Unconjugated bilirubin (UCB) is the end-product of heme catabolism in the intravascular compartment. Although beneficial for human health when mildly elevated in the body, when present at greater than a critical threshold concentration, UCB
Externí odkaz:
https://doaj.org/article/76e84440156a41a0b3afe937582ade16
Publikováno v:
Molecules, Vol 26, Iss 17, p 5160 (2021)
Amine-containing drugs often show poor pharmacological properties, but these disadvantages can be overcome by using a prodrug approach involving self-immolative linkers. Accordingly, we designed l-lactate linkers as ideal candidates for amine deliver
Externí odkaz:
https://doaj.org/article/87e515ac3bbf45af8674cbb73d46f56e
Autor:
Kateřina Lněničková, Eliška Procházková, Lenka Skálová, Petra Matoušková, Hana Bártíková, Pavel Souček, Barbora Szotáková
Publikováno v:
Molecules, Vol 21, Iss 9, p 1186 (2016)
The knowledge of processes in intestinal cells is essential, as most xenobiotics come into contact with the small intestine first. Caco-2 cells are human colorectal adenocarcinoma that once differentiated, exhibit enterocyte-like characteristics. Our
Externí odkaz:
https://doaj.org/article/96e0d28cf1b3489ebefcb1751781a423
Autor:
You Dan Xu, Linqing Tian, Rebecca Yong Lai, Zihao Li, Eliška Procházková, Junming Ho, Martina H. Stenzel
Publikováno v:
Bioconjugate Chemistry. 33:321-332
Preexisting serum albumin-polymer bioconjugates have been formed either through covalent conjugation or supramolecular interactions. However, the viability of producing a bioconjugate where both covalent conjugation and supramolecular interactions ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72daebea820fca8e04b0f27e46952bec
https://doi.org/10.1021/acs.bioconjchem.1c00536
https://doi.org/10.1021/acs.bioconjchem.1c00536
Autor:
Ondřej Štěpánek, Adéla Čmoková, Eliška Procházková, Valéria Grobárová, Jan Černý, Martina Slapničková, Alena Zíková, Miroslav Kolařík, Ondřej Baszczyňski
Publikováno v:
ChemMedChem. 17(21)
Ketoconazole (KTZ) is an imidazole drug applied topically to treat numerous skin infections. However, as a systemic antifungal, KTZ' efficacy and safety no longer justify its use as a first-line treatment. Azole conjugates often display higher solubi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122c13ecf73ae56d434cc9b9d087adc5
https://pubmed.ncbi.nlm.nih.gov/36115047
https://pubmed.ncbi.nlm.nih.gov/36115047
Publikováno v:
ACS Macro Letters. 10:819-824
Albumin has consistently demonstrated its potential for enhancing the delivery of drugs and polymer-drug conjugates, binding via supramolecular forces within its multiple binding sites. Herein, we introduce saturation transfer difference (STD-NMR) as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0312e6fb8ee1feceff199491870001
https://doi.org/10.1021/acsmacrolett.1c00270
https://doi.org/10.1021/acsmacrolett.1c00270
Autor:
Anna Hruzíková, Lucie Mužíková Čechová, Sille Štěpánová, Lucie Tučková, Markéta Tichotová, Aleš Růžička, Václav Kašička, Eliška Procházková
Publikováno v:
Dyes and Pigments. 212:111099
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d76b997cd50120b5a0174f7b3da58164
https://doi.org/10.1016/j.dyepig.2023.111099
https://doi.org/10.1016/j.dyepig.2023.111099
Autor:
Miroslav Kolařík, Oleksandr Kucherak, Ivana Císařová, Eliška Procházková, Miroslav Flieger, Ondřej Baszczyňski, Eva Stodůlková, Zdeněk Tošner
Publikováno v:
Journal of Natural Products. 84:46-55
Naphthoquinones isolated from Quambalaria cyanescens (quambalarines) are natural pigments possessing significant cytotoxic and antimicrobial properties. Determining the structure of naphthoquinone compounds is important for the understanding of their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93b00293303c34fb6e66736183e89928
https://doi.org/10.1021/acs.jnatprod.0c00930
https://doi.org/10.1021/acs.jnatprod.0c00930
Autor:
Aleksander Semenenko, Radek Pohl, Dmytro O. Sysoiev, Svitlana V. Shishkina, Eliška Procházková, Dmytro A. Yushchenko, Blanka Klepetářová, Volodymyr V. Shvadchak
Publikováno v:
ChemPlusChem. 85:2084-2092
Bis(benzothienyl)ethene sulfones are very interesting molecules for super-resolution microscopy due to their photoswitching properties. However, functionalization of the 'classical' bis(benzothienyl)ethene sulfones with a five-membered central ring l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e808f15281f6f1ac9dc2eee294d4c6
https://doi.org/10.1002/cplu.202000481
https://doi.org/10.1002/cplu.202000481