Zobrazeno 1 - 10
of 267
pro vyhledávání: '"Eli, Chapman"'
Autor:
Marissa N. Trujillo, Erin Q. Jennings, Emely A. Hoffman, Hao Zhang, Aiden M. Phoebe, Grace E. Mastin, Naoya Kitamura, Julie A. Reisz, Emily Megill, Daniel Kantner, Mariola M. Marcinkiewicz, Shannon M. Twardy, Felicidad Lebario, Eli Chapman, Rebecca L. McCullough, Angelo D'Alessandro, Nathaniel W. Snyder, Darren A. Cusanovich, James J. Galligan
Publikováno v:
Molecular Metabolism, Vol 81, Iss , Pp 101888- (2024)
Chronic, systemic inflammation is a pathophysiological manifestation of metabolic disorders. Inflammatory signaling leads to elevated glycolytic flux and a metabolic shift towards aerobic glycolysis and lactate generation. This rise in lactate corres
Externí odkaz:
https://doaj.org/article/2715064b1deb49e1a938eed2068d8bb9
Autor:
Aryatara Shakya, Pengfei Liu, Jack Godek, Nicholas W. McKee, Matthew Dodson, Annadurai Anandhan, Aikseng Ooi, Joe G.N. Garcia, Max Costa, Eli Chapman, Donna D. Zhang
Publikováno v:
Redox Biology, Vol 65, Iss , Pp 102839- (2023)
p97 is a ubiquitin-targeted ATP-dependent segregase that regulates proteostasis, in addition to a variety of other cellular functions. Previously, we demonstrated that p97 negatively regulates NRF2 by extracting ubiquitylated NRF2 from the KEAP1-CUL3
Externí odkaz:
https://doaj.org/article/867adb2a581b43de91087339be330784
Autor:
Matthew Dodson, Wujing Dai, Annadurai Anandhan, Cody J. Schmidlin, Pengfei Liu, Nathan C. Wilson, Yongyi Wei, Naoya Kitamura, James J. Galligan, Aikseng Ooi, Eli Chapman, Donna D. Zhang
Publikováno v:
Molecular Oncology, Vol 16, Iss 8, Pp 1714-1727 (2022)
The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is often highly expressed in non‐small cell lung cancer (NSCLC). Through its target genes, NRF2 enhances cancer progression and chemo/radioresistance, leading to a poorer
Externí odkaz:
https://doaj.org/article/94f4ee304dad4931bce3ef765c659f45
Autor:
Pengfei Liu, Annadurai Anandhan, Jinjing Chen, Aryatara Shakya, Matthew Dodson, Aikseng Ooi, Eli Chapman, Eileen White, Joe GN. Garcia, Donna D. Zhang
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102570- (2023)
Background and aims: Caloric excess and sedentary lifestyles have led to an epidemic of obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). The objective of this study was to investigate the mechanisms underlying high fat diet
Externí odkaz:
https://doaj.org/article/a325bd8ab2114b2493bc1dc0404d0d03
Autor:
Derek J. Essegian, Tyler A. Cunningham, Christopher J. Zerio, Eli Chapman, Jonathan Schatz, Stephan C. Schürer
Publikováno v:
ACS Omega, Vol 6, Iss 38, Pp 24432-24443 (2021)
Externí odkaz:
https://doaj.org/article/7980bb329b004d37b04673cf8626bb3d
Autor:
Pengfei Liu, Matthew Dodson, Hui Li, Cody J. Schmidlin, Aryatara Shakya, Yongyi Wei, Joe G.N. Garcia, Eli Chapman, Pawel R. Kiela, Qing-Yu Zhang, Eileen White, Xinxin Ding, Aikseng Ooi, Donna D. Zhang
Publikováno v:
Molecular Metabolism, Vol 51, Iss , Pp 101243- (2021)
Objective: NRF2, a transcription factor that regulates cellular redox and metabolic homeostasis, plays a dual role in human disease. While it is well known that canonical intermittent NRF2 activation protects against diabetes-induced tissue damage, l
Externí odkaz:
https://doaj.org/article/9b6867c4cff24e0b97a6adf722e6305c
Autor:
Jared Sivinski, Andrew J. Ambrose, Iliya Panfilenko, Christopher J. Zerio, Jason M. Machulis, Niloufar Mollasalehi, Lynn K. Kaneko, Mckayla Stevens, Anne-Marie Ray, Yangshin Park, Chunxiang Wu, Quyen Q. Hoang, Steven M. Johnson, Eli Chapman
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
The GroES/GroEL chaperonin from E. coli
Externí odkaz:
https://doaj.org/article/ebd31eb709974744bdcf006fa3005b0d
Publikováno v:
Molecules and Cells. 46:165-175
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::657e5878a89db99f31c8a5ff8ef76c73
https://doi.org/10.14348/molcells.2023.0005
https://doi.org/10.14348/molcells.2023.0005
Autor:
Pengfei Liu, Gang Luo, Matthew Dodson, Cody J. Schmidlin, Yongyi Wei, Baris Kerimoglu, Aikseng Ooi, Eli Chapman, Joe GN. Garcia, Donna D. Zhang
Publikováno v:
Redox Biology, Vol 38, Iss , Pp 101766- (2021)
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible disease characterized by an increase in differentiation of fibroblasts to myofibroblasts and excessive accumulation of extracellular matrix in lung tissue. Pharmacological activati
Externí odkaz:
https://doaj.org/article/effa802854e740848688058352c9fc25
Publikováno v:
PLoS Biology, Vol 18, Iss 2, p e3000620 (2020)
Primary cilia are lost during cancer development, but the mechanism regulating cilia degeneration is not determined. While transcription factor nuclear factor-erythroid 2-like 2 (NRF2) protects cells from oxidative, proteotoxic, and metabolic stress
Externí odkaz:
https://doaj.org/article/85870749871a48f897298f43e7e78f1e