Identification of FDA-approved drugs that induce heart regeneration in mammals.

Autor: Ahmed MS; Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.; These authors contributed equally: Mahmoud Salama Ahmed, Ngoc Uyen Nhi Nguyen., Nguyen NUN; Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.; These authors contributed equally: Mahmoud Salama Ahmed, Ngoc Uyen Nhi Nguyen., Nakada Y; Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL, USA., Hsu CC; Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Farag A; Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Lam NT; Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Wang P; Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Thet S; Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Menendez-Montes I; Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Elhelaly WM; Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Lou X; Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL, USA., Secco I; School of Cardiovascular and Metabolic Medicine & Sciences and British Heart Foundation Centre of Research Excellence, King's College London, London, UK., Tomczyk M; School of Cardiovascular and Metabolic Medicine & Sciences and British Heart Foundation Centre of Research Excellence, King's College London, London, UK., Zentilin L; Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy., Pei J; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Cui M; Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.; Hamon Center for Regenerative Science and Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.; Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Dos Santos M; Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.; Hamon Center for Regenerative Science and Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.; Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Liu X; Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Liu Y; Eugene McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Zaha D; Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Walcott G; Division of Cardiovascular Diseases, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Tomchick DR; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Xing C; Eugene McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Zhang CC; Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Grishin NV; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Giacca M; School of Cardiovascular and Metabolic Medicine & Sciences and British Heart Foundation Centre of Research Excellence, King's College London, London, UK.; Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy., Zhang J; Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL, USA., Sadek HA; Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.; Hamon Center for Regenerative Science and Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2024 Mar; Vol. 3 (3), pp. 372-388. Date of Electronic Publication: 2024 Mar 11.

PKM1 Exerts Critical Roles in Cardiac Remodeling Under Pressure Overload in the Heart.

Autor: Li Q; Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China (Q.L., J.Lin, Y.G., M.W., G.F.).; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Zhejiang, China (Q.L., J.Lin, Y.G., M.W., G.F.).; Division of Cardiology, Department of Internal Medicine (Q.L., C.L., A.E., G.Z., W.M.E., G.C., C.D., C.D.S., X.L., T.G.G., L.I.S., Z.V.W.), University of Texas Southwestern Medical Center, Dallas., Li C; Division of Cardiology, Department of Internal Medicine (Q.L., C.L., A.E., G.Z., W.M.E., G.C., C.D., C.D.S., X.L., T.G.G., L.I.S., Z.V.W.), University of Texas Southwestern Medical Center, Dallas., Elnwasany A; Division of Cardiology, Department of Internal Medicine (Q.L., C.L., A.E., G.Z., W.M.E., G.C., C.D., C.D.S., X.L., T.G.G., L.I.S., Z.V.W.), University of Texas Southwestern Medical Center, Dallas., Sharma G; Advanced Imaging Research Center (G.S., C.R.M.), University of Texas Southwestern Medical Center, Dallas., An YA; Touchstone Diabetes Center, Department of Internal Medicine (Y.A.A., S.Z., Y.D., P.E.S.), University of Texas Southwestern Medical Center, Dallas., Zhang G, Elhelaly WM; Division of Cardiology, Department of Internal Medicine (Q.L., C.L., A.E., G.Z., W.M.E., G.C., C.D., C.D.S., X.L., T.G.G., L.I.S., Z.V.W.), University of Texas Southwestern Medical Center, Dallas., Lin J; Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China (Q.L., J.Lin, Y.G., M.W., G.F.).; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Zhejiang, China (Q.L., J.Lin, Y.G., M.W., G.F.)., Gong Y; Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China (Q.L., J.Lin, Y.G., M.W., G.F.).; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Zhejiang, China (Q.L., J.Lin, Y.G., M.W., G.F.)., Chen G; Division of Cardiology, Department of Internal Medicine (Q.L., C.L., A.E., G.Z., W.M.E., G.C., C.D., C.D.S., X.L., T.G.G., L.I.S., Z.V.W.), University of Texas Southwestern Medical Center, Dallas., Wang M; Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China (Q.L., J.Lin, Y.G., M.W., G.F.).; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Zhejiang, China (Q.L., J.Lin, Y.G., M.W., G.F.)., Zhao S; Touchstone Diabetes Center, Department of Internal Medicine (Y.A.A., S.Z., Y.D., P.E.S.), University of Texas Southwestern Medical Center, Dallas., Dai C; Division of Cardiology, Department of Internal Medicine (Q.L., C.L., A.E., G.Z., W.M.E., G.C., C.D., C.D.S., X.L., T.G.G., L.I.S., Z.V.W.), University of Texas Southwestern Medical Center, Dallas., Smart CD; Division of Cardiology, Department of Internal Medicine (Q.L., C.L., A.E., G.Z., W.M.E., G.C., C.D., C.D.S., X.L., T.G.G., L.I.S., Z.V.W.), University of Texas Southwestern Medical Center, Dallas., Liu J; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC (J.Liu, J.W.L.)., Luo X; Division of Cardiology, Department of Internal Medicine (Q.L., C.L., A.E., G.Z., W.M.E., G.C., C.D., C.D.S., X.L., T.G.G., L.I.S., Z.V.W.), University of Texas Southwestern Medical Center, Dallas., Deng Y; Touchstone Diabetes Center, Department of Internal Medicine (Y.A.A., S.Z., Y.D., P.E.S.), University of Texas Southwestern Medical Center, Dallas., Tan L; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston (L.T., P.L.L.)., Lv SJ; State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China (S-J.L.)., Davidson SM; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge (S.M.D., M.G.V.H.)., Locasale JW; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC (J.Liu, J.W.L.)., Lorenzi PL; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston (L.T., P.L.L.)., Malloy CR; Advanced Imaging Research Center (G.S., C.R.M.), University of Texas Southwestern Medical Center, Dallas.; Department of Internal Medicine (C.R.M.), University of Texas Southwestern Medical Center, Dallas.; Department of Radiology (C.R.M.), University of Texas Southwestern Medical Center, Dallas., Gillette TG; Division of Cardiology, Department of Internal Medicine (Q.L., C.L., A.E., G.Z., W.M.E., G.C., C.D., C.D.S., X.L., T.G.G., L.I.S., Z.V.W.), University of Texas Southwestern Medical Center, Dallas., Vander Heiden MG; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge (S.M.D., M.G.V.H.).; Dana-Farber Cancer Institute, Boston, MA (M.G.V.H.)., Scherer PE; Touchstone Diabetes Center, Department of Internal Medicine (Y.A.A., S.Z., Y.D., P.E.S.), University of Texas Southwestern Medical Center, Dallas., Szweda LI; Division of Cardiology, Department of Internal Medicine (Q.L., C.L., A.E., G.Z., W.M.E., G.C., C.D., C.D.S., X.L., T.G.G., L.I.S., Z.V.W.), University of Texas Southwestern Medical Center, Dallas., Fu G; Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China (Q.L., J.Lin, Y.G., M.W., G.F.).; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Zhejiang, China (Q.L., J.Lin, Y.G., M.W., G.F.)., Wang ZV; Division of Cardiology, Department of Internal Medicine (Q.L., C.L., A.E., G.Z., W.M.E., G.C., C.D., C.D.S., X.L., T.G.G., L.I.S., Z.V.W.), University of Texas Southwestern Medical Center, Dallas.

Publikováno v: Circulation [Circulation] 2021 Aug 31; Vol. 144 (9), pp. 712-727. Date of Electronic Publication: 2021 Jun 09.

A calcineurin-Hoxb13 axis regulates growth mode of mammalian cardiomyocytes.

Autor: Nguyen NUN; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Canseco DC; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Xiao F; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Nakada Y; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Li S; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Lam NT; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Muralidhar SA; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Savla JJ; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Hill JA; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Le V; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Zidan KA; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., El-Feky HW; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Wang Z; Center for Regenerative Science and Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Ahmed MS; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Hubbi ME; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Menendez-Montes I; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Moon J; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Ali SR; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Le V; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Villalobos E; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Mohamed MS; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Elhelaly WM; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Thet S; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Anene-Nzelu CG; Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.; Genome Institute of Singapore, Singapore, Singapore., Tan WLW; Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.; Genome Institute of Singapore, Singapore, Singapore., Foo RS; Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore.; Genome Institute of Singapore, Singapore, Singapore., Meng X; The College of Life Sciences, Northwest University, Xi'an, China., Kanchwala M; Eugene McDermott Center for Human Growth and Development/Center for Human Genetics, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Xing C; Eugene McDermott Center for Human Growth and Development/Center for Human Genetics, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Roy J; Department of Biology, Stanford University, Stanford, California, USA., Cyert MS; Department of Biology, Stanford University, Stanford, California, USA., Rothermel BA; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Sadek HA; Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA. hesham.sadek@utsouthwestern.edu.; Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX, USA. hesham.sadek@utsouthwestern.edu.; Center for Regenerative Science and Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA. hesham.sadek@utsouthwestern.edu.

Publikováno v: Nature [Nature] 2020 Jun; Vol. 582 (7811), pp. 271-276. Date of Electronic Publication: 2020 Apr 22.

C-Kit Cells Do Not Significantly Contribute to Cardiomyogenesis During Neonatal Heart Regeneration.

Autor: Elhelaly WM; Department of Internal Medicine and Center for Regenerative Science and Medicine, The University of Texas Southwestern Medical Center, Dallas (W.M.E., A.C.C., A.H.M.P., A.E., S.E., Y.N., H.A.S.)., Cardoso AC; Department of Internal Medicine and Center for Regenerative Science and Medicine, The University of Texas Southwestern Medical Center, Dallas (W.M.E., A.C.C., A.H.M.P., A.E., S.E., Y.N., H.A.S.).; Brazilian National Laboratory for Biosciences, Center for Research in Energy and Materials, Campinas (A.C.C., A.H.M.P.)., Pereira AHM; Department of Internal Medicine and Center for Regenerative Science and Medicine, The University of Texas Southwestern Medical Center, Dallas (W.M.E., A.C.C., A.H.M.P., A.E., S.E., Y.N., H.A.S.).; Brazilian National Laboratory for Biosciences, Center for Research in Energy and Materials, Campinas (A.C.C., A.H.M.P.)., Elnawasany A; Department of Internal Medicine and Center for Regenerative Science and Medicine, The University of Texas Southwestern Medical Center, Dallas (W.M.E., A.C.C., A.H.M.P., A.E., S.E., Y.N., H.A.S.)., Ebrahimi S; Department of Internal Medicine and Center for Regenerative Science and Medicine, The University of Texas Southwestern Medical Center, Dallas (W.M.E., A.C.C., A.H.M.P., A.E., S.E., Y.N., H.A.S.)., Nakada Y; Department of Internal Medicine and Center for Regenerative Science and Medicine, The University of Texas Southwestern Medical Center, Dallas (W.M.E., A.C.C., A.H.M.P., A.E., S.E., Y.N., H.A.S.)., Sadek HA; Department of Internal Medicine and Center for Regenerative Science and Medicine, The University of Texas Southwestern Medical Center, Dallas (W.M.E., A.C.C., A.H.M.P., A.E., S.E., Y.N., H.A.S.).

Publikováno v: Circulation [Circulation] 2019 Jan 22; Vol. 139 (4), pp. 559-561.