Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Elham Paknia"'
Autor:
Lisa-Marie Funk, Gereon Poschmann, Fabian Rabe von Pappenheim, Ashwin Chari, Kim M. Stegmann, Antje Dickmanns, Marie Wensien, Nora Eulig, Elham Paknia, Gabi Heyne, Elke Penka, Arwen R. Pearson, Carsten Berndt, Tobias Fritz, Sophia Bazzi, Jon Uranga, Ricardo A. Mata, Matthias Dobbelstein, Rolf Hilgenfeld, Ute Curth, Kai Tittmann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Besides vaccines, the development of antiviral drugs targeting SARS-CoV-2 is critical for preventing future COVID outbreaks. The SARS-CoV-2 main protease (Mpro), a cysteine protease with essential functions in viral replication, has been val
Externí odkaz:
https://doaj.org/article/721e5465cdfb4b73a39d8f7ff2da8167
Publikováno v:
Cell Reports, Vol 16, Iss 12, Pp 3103-3112 (2016)
The formation of macromolecular complexes within the crowded environment of cells often requires aid from assembly chaperones. PRMT5 and SMN complexes mediate this task for the assembly of the common core of pre-mRNA processing small nuclear ribonucl
Externí odkaz:
https://doaj.org/article/bf3a2a49ad1d4a1f9249f6e399a30bb9
Autor:
Kai Tittmann, Lisa-Marie Funk, Fabian Rabe von Pappenheim, Marie Wensien, Nora Eulig, Elke Penka, Kim Stegmann, Antje Dickmanns, Matthias Dobbelstein, Ricardo Mata, Jon Uranga, Sophia Bazzi, Tobias Fritz, Ashwin Chari, Elham Paknia, Gaby Heyne, Arwen Pearson, Rolf Hilgenfeld, Ute Curth, Carsten Berndt, Gereon Poschmann
Besides vaccines, the development of antiviral drugs targeting SARS-CoV-2 is critical for stopping the current COVID-19 pandemic and preventing future outbreaks. The SARS-CoV-2 main protease (Mpro), a cysteine protease with essential functions in vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c52d5429e39701bce7669e6b07b16574
https://doi.org/10.21203/rs.3.rs-2341326/v1
https://doi.org/10.21203/rs.3.rs-2341326/v1
Autor:
Lisa-Marie Funk, Gereon Poschmann, Ashwin Chari, Fabian Rabe von Pappenheim, Kim-Maren Stegmann, Antje Dickmanns, Nora Eulig, Marie Wensien, Elham Paknia, Gabi Heyne, Elke Penka, Arwen R. Pearson, Carsten Berndt, Tobias Fritz, Sophia Bazzi, Jon Uranga, Ricardo A. Mata, Matthias Dobbelstein, Rolf Hilgenfeld, Ute Curth, Kai Tittmann
Besides vaccines, the development of antiviral drugs targeting SARS-CoV-2 is critical for stopping the current COVID-19 pandemic and preventing future outbreaks. The SARS-CoV-2 main protease (Mpro), a cysteine protease with essential functions in vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c180ad7c9a84e59bc5f1117bc181f463
https://doi.org/10.1101/2022.04.18.487732
https://doi.org/10.1101/2022.04.18.487732
Autor:
Clemens Schulze-Briese, Gleb Bourenkov, Thomas R. Schneider, Uma L. Dakshinamoorthy, Elham Paknia, Ashwin Chari, Rasmus Fogh, Peter Keller, Gérard Bricogne
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 78:a125-a125
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09511f01b2292b1f0f55f3ed718bcda5
https://doi.org/10.1107/s2053273322098746
https://doi.org/10.1107/s2053273322098746
Publikováno v:
Nature. 587(7832)
Single-particle electron cryo-microscopy (cryo-EM) is a powerful method for solving the three-dimensional structures of biological macromolecules. The technological development of transmission electron microscopes, detectors and automated procedures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1871e2b4ed9b5d3ae72423878c9a08ff
https://pubmed.ncbi.nlm.nih.gov/33487509
https://pubmed.ncbi.nlm.nih.gov/33487509
Publikováno v:
Cell Reports
Cell Reports, Vol 16, Iss 12, Pp 3103-3112 (2016)
Cell Reports, Vol 16, Iss 12, Pp 3103-3112 (2016)
SummaryThe formation of macromolecular complexes within the crowded environment of cells often requires aid from assembly chaperones. PRMT5 and SMN complexes mediate this task for the assembly of the common core of pre-mRNA processing small nuclear r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ca00d5317a4970151f4190619a8e88
Autor:
Elizabeth Sweeney, Elham Paknia, Melanie Refke, Utz Fischer, Roland Kruse, Niklas Schäfer, Alan Fryer, Markus M. Nöthen, Thomas Franz, M. Just, Maurice A.M. van Steensel, Clemens Grimm, Sandra M. Pasternack, Regina C. Betz, Carlos Ferrándiz, Hans Christian Hennies
Publikováno v:
American Journal of Human Genetics, 92(1), 81-87. Cell Press
Hypotrichosis simplex (HS) comprises a group of hereditary isolated alopecias that are characterized by a diffuse and progressive loss of hair starting in childhood and shows a wide phenotypic variability. We mapped an autosomal-dominant form of HS t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc35f09c1251d881d0b751e5dbb0a1f
https://doi.org/10.1016/j.ajhg.2012.10.022
https://doi.org/10.1016/j.ajhg.2012.10.022
Autor:
Jan-Michael Peters, Georg Petzold, Jürgen Markl, Brenda A. Schulman, Holger Stark, Vanessa Möller, Juergen Ohmer, Niels Fischer, Jeremiah J. Frye, Clemens Grimm, Kai Tittmann, Ashwin Chari, Marc A. Jarvis, Utz Fischer, David Haselbach, Oleg M. Ganichkin, Elham Paknia, Michael Tietzel, Jan-Martin Kirves
Publikováno v:
Nature Methods
Molecular machines or macromolecular complexes are supramolecular assemblies of biomolecules that ensure cellular homeostasis. Structure determination of those complexes in a purified state is often a tedious undertaking due to the compositional comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c16bb4a4da0f0b67cfe2019bd889ff
https://pubmed.ncbi.nlm.nih.gov/26237227
https://pubmed.ncbi.nlm.nih.gov/26237227
Publikováno v:
Current opinion in cell biology. 21(3)
Mutations that affect pre-mRNA processing are the cause for many genetic diseases. Most such mutations target cis-acting regulatory sequences in a given transcript, thus preventing its proper maturation. Only recently however, mutations in trans-acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4bd559aa0bd832b278e8c8e28db051
https://pubmed.ncbi.nlm.nih.gov/19286363
https://pubmed.ncbi.nlm.nih.gov/19286363