Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Elham, Khajehali"'
Autor:
Ziva Vuckovic, Jinan Wang, Vi Pham, Jesse I Mobbs, Matthew J Belousoff, Apurba Bhattarai, Wessel AC Burger, Geoff Thompson, Mahmuda Yeasmin, Vindhya Nawaratne, Katie Leach, Emma T van der Westhuizen, Elham Khajehali, Yi-Lynn Liang, Alisa Glukhova, Denise Wootten, Craig W Lindsley, Andrew Tobin, Patrick Sexton, Radostin Danev, Celine Valant, Yinglong Miao, Arthur Christopoulos, David M Thal
Publikováno v:
eLife, Vol 12 (2023)
Allosteric modulation of G protein-coupled receptors (GPCRs) is a major paradigm in drug discovery. Despite decades of research, a molecular-level understanding of the general principles that govern the myriad pharmacological effects exerted by GPCR
Externí odkaz:
https://doaj.org/article/7f71dbdee2334fc988c8a96b377f0938
Publikováno v:
Molecular Biology Reports. 50:2231-2241
Selective serotonin reuptake inhibitors (SSRIs) are the most common class of medicines used for the treatment of major depression. Recent studies have reported an association between depression and inflammation and suggested the significant effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1818e841980aa6060c350a2560f7fa9
https://doi.org/10.1007/s11033-022-08219-x
https://doi.org/10.1007/s11033-022-08219-x
Autor:
Jesse I Mobbs, Vi Pham, Jinan Wang, Ziva Vuckovic, Matthew J Belousoff, Apurba Bhattarai, Wessel AC Burger, Geoff Thompson, Mahmuda Yeasmin, Vindhya Nawaratne, Katie Leach, Emma T van der Westhuizen, Elham Khajehali, Yi-Lynn Liang, Alisa Glukhova, Denise Wootten, Craig W Lindsley, Andrew Tobin, Patrick Sexton, Radostin Danev, Celine Valant, Yinglong Miao, Arthur Christopoulos, David M Thal
Publikováno v:
eLife. 12
Allosteric modulation of G protein-coupled receptors (GPCRs) is a major paradigm in drug discovery. Despite decades of research, a molecular-level understanding of the general principles that govern the myriad pharmacological effects exerted by GPCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a3f8c39932d4142cae5d5abc25a4480
https://doi.org/10.7554/elife.83477
https://doi.org/10.7554/elife.83477
Autor:
Manuela Jörg, Emma T. van der Westhuizen, Yao Lu, K. H. Christopher Choy, David M. Shackleford, Elham Khajehali, Andrew Tobin, David Thal, Ben Capuano, Arthur Christopoulos, Celine Valant, Peter Scammells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b15a8d7eea63a48c1a2875d38a584ede
https://doi.org/10.2139/ssrn.4432468
https://doi.org/10.2139/ssrn.4432468
Autor:
Louis, Dwomoh, Mario, Rossi, Miriam, Scarpa, Elham, Khajehali, Colin, Molloy, Pawel, Herzyk, Shailesh N, Mistry, Andrew R, Bottrill, Patrick M, Sexton, Arthur, Christopoulos, Jeffrey, Conn, Craig W, Lindsley, Sophie J, Bradley, Andrew B, Tobin
Publikováno v:
Science signaling. 15(760)
Many dementias are propagated through the spread of "prion-like" misfolded proteins. This includes prion diseases themselves (such as Creutzfeldt-Jakob disease) and Alzheimer's disease (AD), for which no treatments are available to slow or stop progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee6615158b043fc9f0ea7d2b16efa605
https://pubmed.ncbi.nlm.nih.gov/36378750
https://pubmed.ncbi.nlm.nih.gov/36378750
Autor:
Louis Dwomoh, Mario Rossi, Miriam Scarpa, Elham Khajehali, Colin Molloy, Pawel Herzyk, Shailesh N. Mistry, Andrew R. Bottrill, Patrick M. Sexton, Arthur Christopoulos, Jeffrey Conn, Craig W. Lindsley, Sophie J. Bradley, Andrew B. Tobin
Publikováno v:
Science Signaling. 15
Many dementias are propagated through the spread of “prion-like” misfolded proteins. This includes prion diseases themselves (such as Creutzfeldt-Jakob disease) and Alzheimer’s disease (AD), for which no treatments are available to slow or stop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c168e561d75a13f908e050a3542ed50
https://doi.org/10.1126/scisignal.abm3720
https://doi.org/10.1126/scisignal.abm3720
Background Selective serotonin reuptake inhibitors (SSRIs) as the commonest therapeutic option are used to treat major depression. Recent studies have reported an association between depression and inflammation as well as the significant effect of SS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f7bc51c38d4ce7a2ddf52b662bb2b76
https://doi.org/10.21203/rs.3.rs-2077015/v1
https://doi.org/10.21203/rs.3.rs-2077015/v1
Autor:
Ziva Vuckovic, Jinan Wang, Vi Pham, Jesse I. Mobbs, Matthew J. Belousoff, Apurba Bhattarai, Wessel A.C. Burger, Geoff Thompson, Mahmuda Yeasmin, Katie Leach, Emma T. van der Westhuizen, Elham Khajehali, Yi-Lynn Liang, Alisa Glukhova, Denise Wootten, Craig W. Lindsley, Andrew B. Tobin, Patrick M. Sexton, Radostin Danev, Celine Valant, Yinglong Miao, Arthur Christopoulos, David M. Thal
Allosteric modulation of G protein-coupled receptors (GPCRs) is a major paradigm in drug discovery. Despite decades of research, a molecular level understanding of the general principals that govern the myriad pharmacological effects exerted by GPCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c582d2c3aeeced33d04530cd651f1edd
https://doi.org/10.1101/2022.09.27.509640
https://doi.org/10.1101/2022.09.27.509640
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c220dd58f0845e6db0ced1fb1c92477
https://doi.org/10.1096/fasebj.2022.36.s1.r2328
https://doi.org/10.1096/fasebj.2022.36.s1.r2328
Autor:
Arthur Christopoulos, Colin Molloy, Lisa Finlayson, Emma T van der Westhuizen, Celine Valant, Craig W. Lindsley, Sophie J. Bradley, Patrick M. Sexton, Elham Khajehali, Andrew B. Tobin
Publikováno v:
ACS Chemical Neuroscience. 11:4270-4279
Designer receptors exclusively activated by designer drugs (DREADDs) have been successfully employed to activate signaling pathways associated with specific muscarinic acetylcholine receptor (mAChR) subtypes. The M1 DREADD mAChR displays minimal resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f08b271a3fe2e2704c93343fc1cc1a1
https://doi.org/10.1021/acschemneuro.0c00540
https://doi.org/10.1021/acschemneuro.0c00540