Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Elghraoui A"'
Autor:
Elghraoui, Afif, Valafar, Faramarz
Background: DNA, RNA, and protein sequence motifs can be recognition sites for biological functions such as regulation, DNA base modification, and molecular binding in general. The gain and loss of such motifs can carry important consequences. When c
Externí odkaz:
http://arxiv.org/abs/2210.09842
Autor:
Conkle-Gutierrez, Derek, Gorman, Bria M., Thosar, Nachiket, Elghraoui, Afif, Modlin, Samuel J., Valafar, Faramarz
Publikováno v:
In Drug Resistance Updates November 2024 77
Autor:
Derek Conkle-Gutierrez, Sarah M. Ramirez-Busby, Bria M. Gorman, Afif Elghraoui, Sven Hoffner, Wael Elmaraachli, Faramarz Valafar
Publikováno v:
Frontiers in Microbiology, Vol 14 (2024)
BackgroundRifampicin (RIF) is a key first-line drug used to treat tuberculosis, a primarily pulmonary disease caused by Mycobacterium tuberculosis. RIF resistance is caused by mutations in rpoB, at the cost of slower growth and reduced transcription
Externí odkaz:
https://doaj.org/article/b76eb18710f04ef39fa75e8b8a62b606
Akademický článek
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Autor:
Samuel J. Modlin, Afif Elghraoui, Deepika Gunasekaran, Alyssa M. Zlotnicki, Nicholas A. Dillon, Nermeeta Dhillon, Norman Kuo, Cassidy Robinhold, Carmela K. Chan, Anthony D. Baughn, Faramarz Valafar
Publikováno v:
mSystems, Vol 6, Iss 6 (2021)
ABSTRACT Accurate and timely functional genome annotation is essential for translating basic pathogen research into clinically impactful advances. Here, through literature curation and structure-function inference, we systematically update the functi
Externí odkaz:
https://doaj.org/article/d38fb0ef6dbc4db38915e5bc82ff5dd4
Autor:
Conkle-Gutierrez, Derek, Ramirez-Busby, Sarah M., Gorman, Bria M., Elghraoui, Afif, Hoffner, Sven, Elmaraachli, Wael, Valafar, Faramarz
Publikováno v:
Frontiers in Microbiology; 2024, p1-11, 11p
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-14 (2017)
Abstract Background The genetic basis of virulence in Mycobacterium tuberculosis has been investigated through genome comparisons of virulent (H37Rv) and attenuated (H37Ra) sister strains. Such analysis, however, relies heavily on the accuracy of the
Externí odkaz:
https://doaj.org/article/dd3d627a5be441a0a99533e49029ac73
Akademický článek
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Publikováno v:
Bioinformatics. 39
MotivationThe phylogenetic signal of structural variation informs a more comprehensive understanding of evolution. As (near-)complete genome assembly becomes more commonplace, the next methodological challenge for inferring genome rearrangement trees
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22892b8c1889f0e3c1ab6ea36b3e4d06
https://doi.org/10.1093/bioinformatics/btad024
https://doi.org/10.1093/bioinformatics/btad024
De novo assembly has become commonplace for microbial organisms, increasing the demand for reliable genome annotation. Ab initio annotation is not an ideal approach for closely related strains due to suboptimal matching of the short or hypervariable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98daf590ddbebbe5f4c5ae197d2496f6
https://doi.org/10.1101/2022.11.09.515824
https://doi.org/10.1101/2022.11.09.515824