Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Elfriede Noeßner"'
Autor:
Adrian Schmalen, Ilona E. Kammerl, Silke Meiners, Elfriede Noessner, Cornelia A. Deeg, Stefanie M. Hauck
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1300 (2023)
The majority of peptides presented by MHC class I result from proteasomal protein turnover. The specialized immunoproteasome, which is induced during inflammation, plays a major role in antigenic peptide generation. However, other cellular proteases
Externí odkaz:
https://doaj.org/article/e3164ef2c26140198e4a67d4e9975140
Autor:
Anna Esteve-Codina, Thomas P. Hofer, Dorothe Burggraf, Marion S. Heiss-Neumann, Wolfgang Gesierich, Anne Boland, Robert Olaso, Marie-Therese Bihoreau, Jean-Francois Deleuze, Winfried Moeller, Otmar Schmid, María Soler Artigas, Kathrin Renner, Jens M. Hohlfeld, Tobias Welte, Thomas Fuehner, Lukas Jerrentrup, Andreas Rembert Koczulla, Timm Greulich, Antje Prasse, Joachim Müller-Quernheim, Sumit Gupta, Christopher Brightling, Deepak R. Subramanian, David G. Parr, Umme Kolsum, Vandana Gupta, Imre Barta, Balázs Döme, János Strausz, Mariarita Stendardo, Marco Piattella, Piera Boschetto, Damian Korzybski, Dorota Gorecka, Adam Nowinski, Marc Dabad, Marcos Fernández-Callejo, David Endesfelder, Wolfgang zu Castell, Pieter S. Hiemstra, Per Venge, Elfriede Noessner, Thasso Griebel, Simon Heath, Dave Singh, Ivo Gut, Loems Ziegler-Heitbrock
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Chronic obstructive pulmonary disease (COPD) is a destructive inflammatory disease and the genes expressed within the lung are crucial to its pathophysiology. We have determined the RNAseq transcriptome of bronchial brush cells from 312 stri
Externí odkaz:
https://doaj.org/article/910271cd28a0431e890028bbd9684f22
Autor:
Madhura Modak, Ann-Kathrin Mattes, Daniela Reiss, Wioletta Skronska-Wasek, Rebecca Langlois, Nicolas Sabarth, Renate Konopitzky, Fidel Ramirez, Katharina Lehr, Tobias Mayr, David Kind, Coralie Viollet, Lee Kim Swee, Jutta Petschenka, Karim C. El Kasmi, Elfriede Noessner, Kerstin Kitt, Stefan Pflanz
Publikováno v:
JCI Insight, Vol 7, Iss 11 (2022)
In many solid cancers, tumor-associated macrophages (TAM) represent the predominant myeloid cell population. Antigen (Ag) cross-presentation leading to tumor Ag–directed cytotoxic CD8+ T cell responses is crucial for antitumor immunity. However, th
Externí odkaz:
https://doaj.org/article/4e405ca8fdb049239e02f1107be9dd50
Autor:
Rolf D. Issels, Lars H. Lindner, Michael von Bergwelt-Baildon, Peter Lang, Christoph Rischpler, Heinz Diem, Barbara Mosetter, Judith Eckl, Dolores J. Schendel, Christoph Salat, Oliver Stötzer, Stefan Burdach, Irene von Luettichau-Teichert, Rupert Handgretinger, Jens Neumann, Thomas Kirchner, Katja Steiger, Melanie Boxberg, Ulrich Mansmann, Gabriele Multhoff, Elfriede Noessner
Publikováno v:
International Journal of Hyperthermia, Vol 37, Iss 1, Pp 55-65 (2020)
Introduction An abscopal effect is a clinical observation whereby a local treatment is associated with regression of metastatic cancer at a site distant from the primary location of treatment. Here, we describe the clinical systemic effect induced by
Externí odkaz:
https://doaj.org/article/994f1713490d468e8ea0a0cafdbdc7df
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Activation of co-stimulatory pathways in cytotoxic T lymphocytes expressing chimeric antigen receptors (CARs) have proven to boost effector activity, tumor rejection and long-term T cell persistence. When using antigen-specific T cell receptors (TCR)
Externí odkaz:
https://doaj.org/article/0de3501e8ca94ab1bedcd6a7f66b7639
Autor:
Dorothee Brech, Anna S. Herbstritt, Sarah Diederich, Tobias Straub, Evangelos Kokolakis, Martin Irmler, Johannes Beckers, Florian A. Büttner, Elke Schaeffeler, Stefan Winter, Matthias Schwab, Peter J. Nelson, Elfriede Noessner
Publikováno v:
Cells, Vol 11, Iss 20, p 3289 (2022)
Since their initial description by Elie Metchnikoff, phagocytes have sparked interest in a variety of biologic disciplines. These important cells perform central functions in tissue repair and immune activation as well as tolerance. Myeloid cells can
Externí odkaz:
https://doaj.org/article/3f44b1cff36c45188b6ce3b9a5452c67
Autor:
Chang-Feng Chu, Florian Sabath, Silvia Fibi-Smetana, Shan Sun, Rupert Öllinger, Elfriede Noeßner, Ying-Yin Chao, Linus Rinke, Elena Winheim, Roland Rad, Anne B. Krug, Leila Taher, Christina E. Zielinski
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
COVID-19, the disease caused by SARS-CoV-2 infection, can assume a highly variable disease course, ranging from asymptomatic infection, which constitutes the majority of cases, to severe respiratory failure. This implies a diverse host immune respons
Externí odkaz:
https://doaj.org/article/a4a5a8a224bb40909430cdabe11e9302
Autor:
Gitte Holmen Olofsson, Manja Idorn, Ana Micaela Carnaz Simões, Pia Aehnlich, Signe Koggersbøl Skadborg, Elfriede Noessner, Reno Debets, Bernhard Moser, Özcan Met, Per thor Straten
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The human Vγ9Vδ2 T cell is a unique cell type that holds great potential in immunotherapy of cancer. In particular, the therapeutic potential of this cell type in adoptive cell therapy (ACT) has gained interest. In this regard optimization of in vi
Externí odkaz:
https://doaj.org/article/f3c9003ba1074c3faf2c252ea6733a3b
Autor:
Dorota E. Kuczek, Anne Mette H. Larsen, Marie-Louise Thorseth, Marco Carretta, Adrija Kalvisa, Majken S. Siersbæk, Ana Micaela C. Simões, Anne Roslind, Lars H. Engelholm, Elfriede Noessner, Marco Donia, Inge Marie Svane, Per thor Straten, Lars Grøntved, Daniel H. Madsen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract Background Tumor progression is accompanied by dramatic remodeling of the surrounding extracellular matrix leading to the formation of a tumor-specific ECM, which is often more collagen-rich and of increased stiffness. The altered ECM of the
Externí odkaz:
https://doaj.org/article/a8b31eed6af14bd29e66f25eb8528c73
Autor:
Angelika J. Fischbeck, Svenja Ruehland, Andreas Ettinger, Kerstin Paetzold, Ilias Masouris, Elfriede Noessner, Anna N. Mendler
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Adoptive T cell therapy (ACT) is highly effective in the treatment of hematologic malignancies, but shows limited success in solid tumors. Inactivation of T cells in the tumor milieu is a major hurdle to a wider application of ACT. Cytotoxicity is th
Externí odkaz:
https://doaj.org/article/302c86f4e7e749b2b3d6b3da0510006d