Discovery of potent dihydro-oxazinoquinolinone inhibitors of GuaB for the treatment of tuberculosis.

Autor: Zhou Y; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address: zhou.yuebiao@gene.com., Aliagas I; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Wang S; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Li CS; Wuxi Apptec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China., Liu Z; Wuxi Apptec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China., Bowman CM; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Burdick DJ; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Clark KR; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Dening TJ; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Flygare J; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Ganti A; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Girgis HS; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Hanan EJ; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Harris SF; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Hu C; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Kapadia SB; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Koehler MFT; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Lai T; Wuxi Apptec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China., Liang J; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Liu X; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Ma F; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Mao J; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Nicolai J; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Sims J; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Unhayaker S; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Wai J; Wuxi Apptec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China., Wang X; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Wu P; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Xu Y; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Yen CW; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Zhang R; Wuxi Apptec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China., Elfert TF; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Tan MW; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Kofoed EM; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Crawford TD; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address: terry@gene.com.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Nov 11, pp. 130026. Date of Electronic Publication: 2024 Nov 11.