Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Elfatih Elzein"'
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f72a301dddb04c891c98cf063eaaea2b
https://doi.org/10.1136/jitc-2022-sitc2022.0960
https://doi.org/10.1136/jitc-2022-sitc2022.0960
Autor:
Elfatih Elzein, Cindy Hong Li, Daniel Soohoo, Britton Kenneth Corkey, Chandru Venkataramani, Xiao-Jun Li, Manoj C. Desai, Nesrine El-Bizri, Haibo Jiang, Kobayashi Tetsuya, Nevena Mollova, Sridharan Rajamani, Jason K. Perry, Arvinder Dhalla, Thao Perry, Xiaofen Li, Robert G. Strickley, Notte Gregory, Gerry Rhodes, Ryoko Hirakawa, Luiz Belardinelli, Eve-Irene Lepist, Parkhill Eric Q, Jeff Zablocki, Oliver L. Saunders, Lu Yafan, Rao Kalla, Dmitry Koltun, Cheng Xie, Gongxin Liu, Wei-Qun Wang, Kris M. Kahlig, Bernard P. Murray, Michael Graupe, Guerrero Juan A, Martinez Ruben, Mark Osier, Lufei Hu
Publikováno v:
Journal of Medicinal Chemistry. 59:9005-9017
Late sodium current (late INa) is enhanced during ischemia by reactive oxygen species (ROS) modifying the Nav 1.5 channel, resulting in incomplete inactivation. Compound 4 (GS-6615, eleclazine) a novel, potent, and selective inhibitor of late INa, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d94b0c7942e17b573ee6f2bc8434003
https://doi.org/10.1021/acs.jmedchem.6b00939
https://doi.org/10.1021/acs.jmedchem.6b00939
Autor:
Donglin Guo, Nevena Mollova, Elfatih Elzein, Sridharan Rajamani, Nesrine El-Bizri, Gongxin Liu, Luiz Belardinelli, Kristopher M. Kahlig, Jeff Zablocki, Xiao-Liang Chen, Cindy Hong Li
Publikováno v:
British Journal of Pharmacology. 173:3088-3098
Background and Purpose Enhanced late Na+ current (late INa) in the myocardium is pro-arrhythmic. Inhibition of this current is a promising strategy to stabilize ventricular repolarization and suppress arrhythmias. Here, we describe GS-6615, a selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f37746a20cc21acfbbbaa6363f39e04
https://doi.org/10.1111/bph.13563
https://doi.org/10.1111/bph.13563
Autor:
Elfatih Elzein, Kobayashi Tetsuya, Brian Stafford, Ryoko Hirakawa, Nevena Mollova, Sridharan Rajamani, Belem Avila, Catherine Smith-Maxwell, Thao Perry, Lin Wu, Jennifer Tang, Jeff Zablocki, Xiaofen Li, Wei-Qun Wang, Dmitry Koltun, Parkhill Eric Q, Robert Jiang, Arvinder Dhalla, Luiz Belardinelli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3207-3211
We started with a medium throughput screen of heterocyclic compounds without basic amine groups to avoid hERG and β-blocker activity and identified [1,2,4]triazolo[4,3-a]pyridine as an early lead. Optimization of substituents for Late INa current in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fe40fe24221536f142ea4df6dd02ec
https://doi.org/10.1016/j.bmcl.2016.03.096
https://doi.org/10.1016/j.bmcl.2016.03.096
Autor:
Dmitry O, Koltun, Eric Q, Parkhill, Elfatih, Elzein, Tetsuya, Kobayashi, Gregory T, Notte, Rao, Kalla, Robert H, Jiang, Xiaofen, Li, Thao D, Perry, Belem, Avila, Wei-Qun, Wang, Catherine, Smith-Maxwell, Arvinder K, Dhalla, Sridharan, Rajamani, Brian, Stafford, Jennifer, Tang, Nevena, Mollova, Luiz, Belardinelli, Jeff A, Zablocki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3202-3206
We started with a medium throughput screen of heterocyclic compounds without basic amine groups to avoid hERG and β-blocker activity and identified [1,2,4]triazolo[4,3-a]pyridine as an early lead. Optimization of substituents for Late INa current in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef515260de6068eed1fe5a0177f0bb65
https://doi.org/10.1016/j.bmcl.2016.03.101
https://doi.org/10.1016/j.bmcl.2016.03.101
Autor:
Leanna Lagpacan, Christopher Allen Ziebenhaus, Bruno Marchand, Elfatih Elzein, Jason K. Perry, Bernard P. Murray, Scott Preston Simonovich, Parkhill Eric Q, Armando G. Villaseñor, WaiLok K. Hung, Nikos Pagratis, Rao Kalla, Jeff Zablocki, Dmitry Koltun, John R. Somoza, Timothy R. Hansen, Ron Aoyama, Thao Perry, Magdeleine Hung, Xiaofen Li
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(3)
We hereby disclose the discovery of inhibitors of CaMKII (7h and 7i) that are highly potent in rat ventricular myocytes, selective against hERG and other off-target kinases, while possessing good CaMKII tissue isoform selectivity (cardiac γ/δ vs. n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caba80ce7be1413193b5f5243755c5aa
https://pubmed.ncbi.nlm.nih.gov/29254643
https://pubmed.ncbi.nlm.nih.gov/29254643
Autor:
Jeff A, Zablocki, Elfatih, Elzein, Xiaofen, Li, Dmitry O, Koltun, Eric Q, Parkhill, Tetsuya, Kobayashi, Ruben, Martinez, Britton, Corkey, Haibo, Jiang, Thao, Perry, Rao, Kalla, Gregory T, Notte, Oliver, Saunders, Michael, Graupe, Yafan, Lu, Chandru, Venkataramani, Juan, Guerrero, Jason, Perry, Mark, Osier, Robert, Strickley, Gongxin, Liu, Wei-Qun, Wang, Lufei, Hu, Xiao-Jun, Li, Nesrine, El-Bizri, Ryoko, Hirakawa, Kris, Kahlig, Cheng, Xie, Cindy Hong, Li, Arvinder K, Dhalla, Sridharan, Rajamani, Nevena, Mollova, Daniel, Soohoo, Eve-Irene, Lepist, Bernard, Murray, Gerry, Rhodes, Luiz, Belardinelli, Manoj C, Desai
Publikováno v:
Journal of medicinal chemistry. 59(19)
Late sodium current (late I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::42002de8c78a8f6b8aa2978518cc834f
https://pubmed.ncbi.nlm.nih.gov/27690427
https://pubmed.ncbi.nlm.nih.gov/27690427
Autor:
Xiaofen Li, Rao Kalla, Art Gimbel, Thao Perry, Elfatih Elzein, Jeff Zablocki, Ming Yang, Dewan Zeng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1397-1401
A series of N-1 monosubstituted 8-pyrazolyl xanthines have been synthesized and evaluated for their affinity for the adenosine receptors (AdoRs). We have discovered two compounds 18 (CVT-7124) and 28 (CVT-6694) that display good affinity for the A(2B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ad952cae86b92e38484b3004599916
https://doi.org/10.1016/j.bmcl.2008.01.008
https://doi.org/10.1016/j.bmcl.2008.01.008
Publikováno v:
Expert Opinion on Therapeutic Patents. 16:1347-1357
The intense efforts by many pharmaceutical companies and academics in the A2B adenosine receptor (AdoR) antagonist field are driven by the plethora of disease states where the A2B AdoR has been implicated to play a role: asthma, in which it mediates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22bc2ee4c7e00da19c15fce8d7bbfa66
https://doi.org/10.1517/13543776.16.10.1347
https://doi.org/10.1517/13543776.16.10.1347
Autor:
Kwan Leung, Ken Rehder, Xiaofen Li, Bob Jiang, Marie Nguyen, Timothy A. Marquart, Nancy Chu, Victoria Y. Maydanik, David Lustig, Kevin D. Shenk, Yuan Li, Elfatih Elzein, Reina Natero, Daniel Soohoo, Prabha Ibrahim, Jeff Zablocki, Suresh S. Kerwar, Dmitry Koltun, Jia Hao, Dewan Zeng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:6017-6021
New inhibitors of palmitoyl-CoA oxidation are based on the introduction of nitrogen heterocycles in the ‘Western Portion’ of the molecule. SAR studies led to the discovery of CVT-4325 (shown), a potent FOXi (IC50 = 380 nM rat mitochondria) with f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80324da80b70144f2e62fa211bc8e33
https://doi.org/10.1016/j.bmcl.2004.09.077
https://doi.org/10.1016/j.bmcl.2004.09.077