Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Eleri Hughes"'
Autor:
Eleri Hughes, David A Middleton
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106746 (2014)
Phospholamban (PLB) is a pentameric protein that plays an important role in regulating cardiac contractility via a reversible inhibitory association with the sarcoplasmic reticulum Ca2+ATPase (SERCA), the enzyme responsible for maintaining correct ca
Externí odkaz:
https://doaj.org/article/570bf7d204674ee8a5a4c9938244bbf5
Publikováno v:
Chemical Communications. 55:13287-13290
NMR measurements of 19F chemical shift anisotropy and 1H-19F dipolar couplings provide unprecedented information on the molecular orientations of two fluorine-containing statin drugs within the heterogeneous environment of reconstituted high-density
Publikováno v:
Physical Chemistry Chemical Physics. 20:18207-18215
Fluorine is often incorporated into the aromatic moieties of synthetic bioactive molecules such as pharmaceuticals and disease diagnostics in order to alter their physicochemical properties. Fluorine substitution may increase a molecule's lipophilici
Autor:
David A. Middleton, David Townsend, Giuliano Siligardi, Eleri Hughes, Sara J. Baldock, Jillian Madine, Rohanah Hussain
Publikováno v:
Biochemistry
Peptides derived from apolipoprotein A-I (apoA-I), the main component of high-density lipoprotein (HDL), constitute the main component of amyloid deposits that colocalize with atherosclerotic plaques. Here we investigate the molecular details of full
Autor:
David Townsend, David A. Middleton, Eleri Hughes, Sheena E. Radford, Katie L. Stewart, John M. Griffin
With amyloid diseases poised to become a major health burden in countries with aging populations, diagnostic molecules that aid the detection of amyloid in vitro and in vivo are of considerable clinical value. Understanding how such ligands recognize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9757da641052980f86396137462ef289
https://doi.org/10.1021/acs.jpclett.8b02448
https://doi.org/10.1021/acs.jpclett.8b02448
Publikováno v:
Physical Chemistry Chemical Physics
An NMR approach is described for determining the orientational preference of bioactive fluoroaromatic molecules within lipid bilayers, by combining measurements of 19F chemical shift anisotropy with the detection of 1H–19F dipolar couplings.
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Autor:
David A. Middleton, Geoffrey R. Akien, Eleri Hughes, David Townsend, David L Rochester, Katie L. Stewart, Sheena E. Radford
Publikováno v:
The Journal of Biological Chemistry
Amyloid deposits of wild-type apolipoprotein A-I (apoA-I), the main protein component of high-density lipoprotein, accumulate in atherosclerotic plaques where they may contribute to coronary artery disease by increasing plaque burden and instability.
Publikováno v:
Biochemistry. 52:8984-8992
Amyloid deposits in vivo are complex mixtures composed of protein fibrils and nonfibrillar components, including polysaccharides of the glycosaminoglycan (GAG) class. It has been widely documented that GAGs influence the initiation and progress of se
Autor:
Katie L, Stewart, Eleri, Hughes, Edwin A, Yates, Geoffrey R, Akien, Teng-Yi, Huang, Marcelo A, Lima, Timothy R, Rudd, Marco, Guerrini, Shang-Cheng, Hung, Sheena E, Radford, David A, Middleton
Publikováno v:
Journal of the American Chemical Society. 138(27)
The amyloid plaques associated with Alzheimer's disease (AD) comprise fibrillar amyloid-β (Aβ) peptides as well as non-protein factors including glycosaminoglycan (GAG) polysaccharides. GAGs affect the kinetics and pathway of Aβ self-assembly and
Autor:
David A. Middleton, Li-Jun Ruan, Mikael Esmann, Hai-Yan Tian, Ren-Wang Jiang, Guang-Ping Liang, Jason T.C. Tzen, Tse-Yu Chung, Eleri Hughes, Wen-Cai Ye, Hong-Jin Tang, Natalya U. Fedosova
Publikováno v:
Scientific Reports
Tang, H-J, Ruan, L-J, Tian, H-Y, Liang, G-P, Ye, W-C, Hughes, E, Esmann, M, Fedosova, N, Chung, T-Y, Tzen, J T C, Jiang, R-W & Middleton, D 2016, ' Novel stereoselective bufadienolides reveal new insights into the requirements for Na,K-ATPase inhibition by cardiotonic steroids ', Scientific Reports . https://doi.org/10.1038/srep29155
Tang, H-J, Ruan, L-J, Tian, H-Y, Liang, G-P, Ye, W-C, Hughes, E, Esmann, M, Fedosova, N, Chung, T-Y, Tzen, J T C, Jiang, R-W & Middleton, D 2016, ' Novel stereoselective bufadienolides reveal new insights into the requirements for Na,K-ATPase inhibition by cardiotonic steroids ', Scientific Reports . https://doi.org/10.1038/srep29155
Cardiotonic steroids (CTS) are clinically important drugs for the treatment of heart failure owing to their potent inhibition of cardiac Na+, K+-ATPase (NKA). Bufadienolides constitute one of the two major classes of CTS, but little is known about ho