Výsledky vyhledávání - "Eleonora Vertecchi"

Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders

Autor: Federica Moraca, Simona Marzano, Francesco D'Amico, Antonio Lupia, Silvia Di Fonzo, Eleonora Vertecchi, Erica Salvati, Anna Di Porzio, Bruno Catalanotti, Antonio Randazzo, Bruno Pagano, Jussara Amato

Publikováno v: Chemical Communications. 58:11913-11916

The single-stranded RNA genome of SARS-CoV-2 contains some G-quadruplex-forming G-rich elements which are putative drug targets. Here, we performed a ligand-based pharmacophore virtual screening of FDA approved drugs to find candidates targeting such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0fe5d1eb600bdc863084b49eb9789e3
https://doi.org/10.1039/d2cc03135c

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Telomere targeting approaches in cancer: beyond length maintenance

Autor: Eleonora Vertecchi, Erica Salvati, Angela Rizzo

Telomeres are crucial structures that preserve genome stability. Their progressive erosion over numerous DNA duplications determines the senescence of cells and organisms. As telomere length homeostasis is critical for cancer development, nowadays, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2a85f06abd0a8b8ec52b7a068c963c
https://hdl.handle.net/11573/1670325

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Telomere Targeting Approaches in Cancer: Over the Length Maintenance

Autor: A. Rizzo, Eleonora Vertecchi, Erica Salvati

Telomeres are crucial structures that preserve genome stability. Their progressive erosion over rounds of DNA duplication determines senescence of cells and organisms. Telomere length homeostasis is critical for cancer development then telomere maint

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd6911dc83a81c95c0bc296f30946b1
https://doi.org/10.20944/preprints202111.0367.v1

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Targeting of Telomeric Repeat-Containing RNA G-Quadruplexes: From Screening to Biophysical and Biological Characterization of a New Hit Compound

Autor: Bruno Pagano, Erica Salvati, Simona Marzano, Stefano De Tito, Eleonora Vertecchi, Jussara Amato, Anna Di Porzio, Nunzia Iaccarino, Antonio Randazzo

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 10315, p 10315 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 19

DNA G-quadruplex (G4) structures, either within gene promoter sequences or at telomeres, have been extensively investigated as potential small-molecule therapeutic targets. However, although G4s forming at the telomeric DNA have been extensively inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f20cfa33c2d6415fc14d7a244f853ab
https://www.mdpi.com/1422-0067/22/19/10315

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An Update of Molecular Basis of Telomere Biology Diseases

Autor: Eleonora Vertecchi, Angela Iuzzolino, Erica Salvati

Telomeres are crucial structures that preserve genome stability. Their progressive erosion over rounds of DNA duplication determines senescence of cells and organisms. In a classic view, telomere biology impinges on intracellular signaling pathways r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca5ab20a707fd7044018dc47350c954
https://doi.org/10.20944/preprints202102.0351.v1

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