Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Eleonora Laritsky"'
Autor:
Wen-Jou Chang, Maria S. Baker, Eleonora Laritsky, Chathura J. Gunasekara, Uditha Maduranga, Justine C. Galliou, Joseph W. McFadden, Jessica R. Waltemyer, Bruce Berggren-Thomas, Brianna N. Tate, Hanxue Zhang, Benjamin D. Rosen, Curtis P. Van Tassell, George E. Liu, Cristian Coarfa, Yi Athena Ren, Robert A. Waterland
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background We recently identified ~ 10,000 correlated regions of systemic interindividual epigenetic variation (CoRSIVs) in the human genome. These methylation variants are amenable to population studies, as DNA methylation measurements in b
Externí odkaz:
https://doaj.org/article/d374279e13bb4fddb9705909460fcb20
Autor:
Chathura J. Gunasekara, Harry MacKay, C. Anthony Scott, Shaobo Li, Eleonora Laritsky, Maria S. Baker, Sandra L. Grimm, Goo Jun, Yumei Li, Rui Chen, Joseph L. Wiemels, Cristian Coarfa, Robert A. Waterland
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract Background Genetic variants can modulate phenotypic outcomes via epigenetic intermediates, for example at methylation quantitative trait loci (mQTL). We present the first large-scale assessment of mQTL at human genomic regions selected for i
Externí odkaz:
https://doaj.org/article/d2673718183743649c5bae8c0315c583
Autor:
C. Anthony Scott, Jack D. Duryea, Harry MacKay, Maria S. Baker, Eleonora Laritsky, Chathura J. Gunasekara, Cristian Coarfa, Robert A. Waterland
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-23 (2020)
Abstract Background The traditional approach to studying the epigenetic mechanism CpG methylation in tissue samples is to identify regions of concordant differential methylation spanning multiple CpG sites (differentially methylated regions). Variati
Externí odkaz:
https://doaj.org/article/4ae1ac73f7754ba3b8068bc641735177
Autor:
Harry MacKay, C. Anthony Scott, Jack D. Duryea, Maria S. Baker, Eleonora Laritsky, Amanda E. Elson, Theodore Garland Jr., Marta L. Fiorotto, Rui Chen, Yumei Li, Cristian Coarfa, Richard B. Simerly, Robert A. Waterland
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
AgRP neurons in the hypothalamic arcuate nucleus (ARH) are involved in regulating hunger and energy balance. Here the authors show that knockout of the DNA methyltransferase Dnmt3a in AgRP neurons of the ARH leads to a reduction in voluntary exercise
Externí odkaz:
https://doaj.org/article/3ce73e60fe8e45fe8361296ab5b90707
Autor:
Chathura J. Gunasekara, C. Anthony Scott, Eleonora Laritsky, Maria S. Baker, Harry MacKay, Jack D. Duryea, Noah J. Kessler, Garrett Hellenthal, Alexis C. Wood, Kelly R. Hodges, Manisha Gandhi, Amy B. Hair, Matt J. Silver, Sophie E. Moore, Andrew M. Prentice, Yumei Li, Rui Chen, Cristian Coarfa, Robert A. Waterland
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background DNA methylation is thought to be an important determinant of human phenotypic variation, but its inherent cell type specificity has impeded progress on this question. At exceptional genomic regions, interindividual variation in DN
Externí odkaz:
https://doaj.org/article/5ad1e273b23e4b7b8400bfdedb7d6255
Autor:
Timothy E. Van Baak, Cristian Coarfa, Pierre-Antoine Dugué, Giovanni Fiorito, Eleonora Laritsky, Maria S. Baker, Noah J. Kessler, Jianrong Dong, Jack D. Duryea, Matt J. Silver, Ayden Saffari, Andrew M. Prentice, Sophie E. Moore, Akram Ghantous, Michael N. Routledge, Yun Yun Gong, Zdenko Herceg, Paolo Vineis, Gianluca Severi, John L. Hopper, Melissa C. Southey, Graham G. Giles, Roger L. Milne, Robert A. Waterland
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-20 (2018)
Abstract Background Monozygotic twins have long been studied to estimate heritability and explore epigenetic influences on phenotypic variation. The phenotypic and epigenetic similarities of monozygotic twins have been assumed to be largely due to th
Externí odkaz:
https://doaj.org/article/d717c5547306414888fccbb11bec07c0
Autor:
Robert A Waterland, Richard Kellermayer, Eleonora Laritsky, Pura Rayco-Solon, R Alan Harris, Michael Travisano, Wenjuan Zhang, Maria S Torskaya, Jiexin Zhang, Lanlan Shen, Mark J Manary, Andrew M Prentice
Publikováno v:
PLoS Genetics, Vol 6, Iss 12, p e1001252 (2010)
Throughout most of the mammalian genome, genetically regulated developmental programming establishes diverse yet predictable epigenetic states across differentiated cells and tissues. At metastable epialleles (MEs), conversely, epigenotype is establi
Externí odkaz:
https://doaj.org/article/22fb21c93460465bbf41d2d3353e3175
Autor:
Chathura J Gunasekara, Jack D. Duryea, C. Anthony Scott, Eleonora Laritsky, Robert A. Waterland, Harry MacKay, Maria S. Baker, Cristian Coarfa
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-23 (2020)
Genome Biology
Genome Biology
Background The traditional approach to studying the epigenetic mechanism CpG methylation in tissue samples is to identify regions of concordant differential methylation spanning multiple CpG sites (differentially methylated regions). Variation limite
Autor:
Andrew M. Prentice, Robert A. Waterland, Eleonora Laritsky, Noah J. Kessler, David Jeffries, Chathura J Gunasekara, Matt J. Silver, Philip James, Marian Ludgate, Kate A Ward, Sophie E. Moore, Rajavel Elango, Toby Candler, Maria S. Baker, Roger A. Dyer
Publikováno v:
Science Advances
Description
Child PAX8 methylation is associated with thyroid volume and function and influenced by maternal periconceptional nutrition.
PAX8 is a key thyroid transcription factor implicated in thyroid gland differentiation and function, an
Child PAX8 methylation is associated with thyroid volume and function and influenced by maternal periconceptional nutrition.
PAX8 is a key thyroid transcription factor implicated in thyroid gland differentiation and function, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ad44f0389929233d8693d498ea5e0e
https://www.repository.cam.ac.uk/handle/1810/332188
https://www.repository.cam.ac.uk/handle/1810/332188
Autor:
Rui Chen, C. Anthony Scott, Yumei Li, Robert A. Waterland, Theodore Garland, Jack D. Duryea, Marta L. Fiorotto, Maria S. Baker, Richard B. Simerly, Eleonora Laritsky, Cristian Coarfa, Amanda E. Elson, Harry MacKay
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
DNA methylation regulates cell type-specific gene expression. Here, in a transgenic mouse model, we show that deletion of the gene encoding DNA methyltransferase Dnmt3a in hypothalamic AgRP neurons causes a sedentary phenotype characterized by reduce