NGN2 mmRNA-Based Transcriptional Programming in Microfluidic Guides hiPSCs Toward Neural Fate With Multiple Identities

Autor: Anna Maria Tolomeo, Cecilia Laterza, Eleonora Grespan, Federica Michielin, Isaac Canals, Zaal Kokaia, Maurizio Muraca, Onelia Gagliano, Nicola Elvassore

Publikováno v: Frontiers in Cellular Neuroscience, Vol 15 (2021)

Recent advancements in cell engineering have succeeded in manipulating cell identity with the targeted overexpression of specific cell fate determining transcription factors in a process named transcriptional programming. Neurogenin2 (NGN2) is suffic

Externí odkaz: https://doaj.org/article/70fb9a7e10ef467b87f3bb33ca6e744c

Nuclear Morphological Remodeling in Human Granulocytes Is Linked to Prenylation Independently from Cytoskeleton

Autor: Sebastian Martewicz, Camilla Luni, Xi Zhu, Meihua Cui, Manli Hu, Siqi Qu, Damiano Buratto, Guang Yang, Eleonora Grespan, Nicola Elvassore

Publikováno v: Cells, Vol 9, Iss 11, p 2509 (2020)

Nuclear shape modulates cell behavior and function, while aberrant nuclear morphologies correlate with pathological phenotype severity. Nevertheless, functions of specific nuclear morphological features and underlying molecular mechanisms remain poor

Externí odkaz: https://doaj.org/article/8e3b439265f448ca98736bad02430447

Micropillar-based phenotypic screening platform uncovers involvement of HDAC2 in nuclear deformability

Autor: Sebastian Martewicz, Xi Zhu, Siqi Qu, Meihua Cui, Eleonora Grespan, Camilla Luni, Biao Jiang, Guang Yang, Nicola Elvassore

Publikováno v: Biomaterials. 286

Nuclear deformation is an essential phenomenon allowing cell migration and can be observed in association with pathological conditions such as laminopathies, neurodegenerative disorders and diabetes. Abnormal nuclear morphologies are a hallmark of ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbb497ba3c3c2a58fa60fa44080d8d8
https://pubmed.ncbi.nlm.nih.gov/35576810

Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT:An IMI DIRECT Study

Autor: Anubha Mahajan, Tarja Kokkola, Mark Walker, Torben Hansen, Femke Rutters, Tue H. Hansen, Jagadish Vangipurapu, Christian S. Göbl, Kristine H. Allin, Andrea Mari, Jerzy Adamski, Martin Ridderstråle, Petra J. M. Elders, Ana Viñuela, Konstantinos D. Tsirigos, Eleonora Grespan, Jochen M. Schwenk, Imre Pavo, Anitra D.M. Koopman, Henrik Vestergaard, Joline W. J. Beulens, Markku Laakso, Ian M Forgie, Timothy J. McDonald, Mark I. McCarthy, Robert W. Koivula, Andrea Tura, Giuseppe N. Giordano, Federico De Masi, Ewan R. Pearson, Oluf Pedersen, Emmanouil T. Dermitzakis, Henna Cederberg, Hartmut Ruetten, Søren Brunak, Paul W. Franks

Publikováno v: Tura, A, Grespan, E, Göbl, C S, Koivula, R W, Franks, P W, Pearson, E R, Walker, M, Forgie, I M, Giordano, G N, Pavo, I, Ruetten, H, Dermitzakis, E T, McCarthy, M I, Pedersen, O, Schwenk, J M, Adamski, J, De Masi, F, Tsirigos, K D, Brunak, S, Viñuela, A, Mahajan, A, McDonald, T J, Kokkola, T, Vangipurapu, J, Cederberg, H, Laakso, M, Rutters, F, Elders, P J M, Koopman, A D M, Beulens, J W, Ridderstråle, M, Hansen, T H, Allin, K H, Hansen, T, Vestergaard, H & Mari, A 2021, ' Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT : An IMI DIRECT Study ', Diabetes, vol. 70, no. 9, pp. 2092-2106 . https://doi.org/10.2337/db21-0227
IMI DIRECT Consortium 2021, ' Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT : An IMI DIRECT Study ', Diabetes, vol. 70, no. 9, pp. 2092-2106 . https://doi.org/10.2337/db21-0227
Diabetes, 70(9), 2092-2106. American Diabetes Association Inc.
Tura, A, Grespan, E, Göbl, C S, Koivula, R W, Franks, P W, Pearson, E R, Walker, M, Forgie, I M, Giordano, G N, Pavo, I, Ruetten, H, Dermitzakis, E T, McCarthy, M I, Pedersen, O, Schwenk, J M, Adamski, J, De Masi, F, Tsirigos, K D, Brunak, S, Viñuela, A, Mahajan, A, McDonald, T J, Kokkola, T, Vangipurapu, J, Cederberg, H, Laakso, M, Rutters, F, Elders, P J M, Koopman, A D M, Beulens, J W, Ridderstråle, M, Hansen, T H, Allin, K H, Hansen, T, Vestergaard, H, Mari, A & IMI-DIRECT consortium 2021, ' Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT : An IMI DIRECT study ', Diabetes, vol. 70, no. 6, db210227 . https://doi.org/10.2337/db21-0227
Diabetes 70, 2092-2106 (2021)

Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 months. HbA1c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe3fd6707df448f60afcf2eb791a6b7
https://orbit.dtu.dk/en/publications/e05b676e-e47c-43cf-a437-7d574d852e66

Mathematical Modeling for the Physiological and Clinical Investigation of Glucose Homeostasis and Diabetes

Autor: Roberto Bizzotto, Andrea Mari, Eleonora Grespan, Andrea Tura

Publikováno v: Frontiers in Physiology
Frontiers in Physiology, Vol 11 (2020)

Mathematical modeling in the field of glucose metabolism has a longstanding tradition. The use of models is motivated by several reasons. Models have been used for calculating parameters of physiological interest from experimental data indirectly, to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcecefbd65c71f101ce3fd09b86af4cb
https://pubmed.ncbi.nlm.nih.gov/33324238