Výsledky vyhledávání - "Eleonora Feketova"

Oral pretreatment with recombinant human lactoferrin limits trauma-hemorrhagic shock–induced gut injury and the biological activity of mesenteric lymph

Autor: Elizabeth J. Quackenbush, Julie Y. Son, Benjamin Chandler, Yung Qin, Eleonora Feketova, Edwin A. Deitch

Publikováno v: Journal of Surgical Research. 187:270-277

Background Lactoferrin (LF) is a pleiotropic glycoprotein that is found in bodily secretions and is postulated to enhance the gastrointestinal barrier and promote mucosal immunity. Thus, the ability of talactoferrin, an oral recombinant form of human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc0f77d704bf99f0ae7b2b7234fe603d
https://doi.org/10.1016/j.jss.2013.10.026

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Recombinant Factor XIII Mitigates Hemorrhagic Shock-Induced Organ Dysfunction

Autor: Inga Malinina, Sergey B. Zaets, Eleonora Feketova, Tamara L. Berezina, Eva H. N. Olsen, Edwin A. Deitch, Qi Lu, Da-Zhong Xu

Publikováno v: Journal of Surgical Research. 166:e135-e142

Background Plasma factor XIII (FXIII) is responsible for stabilization of fibrin clot at the final stage of blood coagulation. Since FXIII has also been shown to modulate inflammation, endothelial permeability, as well as diminish multiple organ dysf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8859741ce21242c8f57f9833ae7059
https://doi.org/10.1016/j.jss.2010.12.001

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Trauma-hemorrhagic shock-induced red blood cell damage leads to decreased microcirculatory blood flow*

Autor: Eleonora Feketova, Tamara L. Berezina, Da Zhong Xu, Zoltán Spolarics, Edwin A. Deitch, Sergey B. Zaets, George W. Machiedo

Publikováno v: Critical Care Medicine. 37:1000-1010

Objective: To test the hypothesis that trauma-hemorrhagic shock (T/HS)-induced changes in red blood cells (RBC) contribute to the reduction of blood flow in distant organs. Design: Laboratory study. Setting: Academic medical center laboratory. Subjec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d06cef6460e2ca6014c644c76a8832c
https://doi.org/10.1097/ccm.0b013e3181962d39

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Alteration of α-spectrin ubiquitination after hemorrhagic shock

Autor: Michael R. Condon, George W. Machiedo, Da-Zhang Xu, Eleonora Feketova, Kimberly Caprio, Edward A. Deitch

Publikováno v: The American Journal of Surgery. 196:663-669

Background RBC deformability after trauma and hemorrhagic shock (T/HS) leads to the microcirculatory dysfunction and clinical manifestations of organ failure. However, the cellular mechanism of this phenomenon remains unknown. Spectrins are important

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da2cf58e43952e11dc07f9c4de943482
https://doi.org/10.1016/j.amjsurg.2008.07.019

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Augmented erythrocyte band-3 phosphorylation in septic mice

Autor: Edwin A. Deitch, George W. Machiedo, Zoltán Spolarics, Michael R. Condon, Eleonora Feketova

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1772:580-586

Infection-induced RBC dysfunction has been shown to play a role in the modulation of host response to injury and infection. The underlying biochemical mechanisms are not known. This study investigated alterations in RBC band-3 phosphorylation status

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3485b3cc56d73924a31af9ade6a5715e
https://doi.org/10.1016/j.bbadis.2007.02.004

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Does recombinant factor XIII eliminate early manifestations of multiple-organ injury after experimental burn similarly to gut ischemia-reperfusion injury or trauma-hemorrhagic shock?

Autor: Eva H. N. Olsen, Sergey B. Zaets, Qi Lu, Inga Malinina, Edwin A. Deitch, Eleonora Feketova, Tamara L. Berezina, Da-Zhong Xu

Publikováno v: Journal of burn careresearch : official publication of the American Burn Association. 35(4)

The authors have previously shown that recombinant factor XIII (rFXIII) eliminates early manifestations of multiple-organ injury caused by experimental superior mesenteric artery occlusion or trauma-hemorrhagic shock. The aim of the present study was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dcad66d507bf9ddfc844e76795abab1
https://pubmed.ncbi.nlm.nih.gov/24043240

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Parasympathetic stimulation via the vagus nerve prevents systemic organ dysfunction by abrogating gut injury and lymph toxicity in trauma and shock

Autor: Da-Zhong Xu, Wei Dong, Vamsi Alli, Luis Ulloa, Gal Levy, Benjamin Chandler, Eleonora Feketova, Jordan E. Fishman, Edwin A. Deitch, Yong Qin

Publikováno v: Shock, 39(5), 460-461. LIPPINCOTT WILLIAMS & WILKINS

Trauma, hemorrhagic shock (T/HS), and subsequent multiple organ dysfunction syndrome (MODS) remain a current challenge in modern medicine. During trauma-hemorrhagic shock, intestinal injury and increased permeability leads to the generation of tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a632e3cc7af8e626664c71797fca4a
https://cris.maastrichtuniversity.nl/en/publications/4557228c-95dc-40ba-9139-841995275cea

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Intravenous Injection of Mesenteric Lymph Produced During Hemorrhagic Shock Decreases RBC Deformability in the Rat

Autor: Da Zhong Xu, Maheswari Senthil, George W. Machiedo, Edwin A. Deitch, Sharvil U. Sheth, Michael R. Condon, Leonard Mason, Zoltán Spolarics, Eleonora Feketova

Increasing evidence from both preclinical and clinical studies-indicate that red blood cells (RBC) alterations or dysfunction plays a role in the pathogenesis of the multiple organ dysfunction syndrome (MODS) in patients sustaining major trauma, espe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93803bf2118657edfd728b6cae026391
https://europepmc.org/articles/PMC3684280/

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RECOMBINANT FACTOR XIII DIMINISHES MULTIPLE ORGAN DYSFUNCTION IN RATS CAUSED BY GUT ISCHEMIA-REPERFUSION INJURY

Autor: Inga Malinina, Sergey B. Zaets, Eva H. N. Olsen, Maryann Gruda, Edwin A. Deitch, Qi Lu, Eleonora Feketova, Da-Zhong Xu, Tamara L. Berezina

Plasma factor XIII (FXIII) is responsible for stabilization of fibrin clot at the final stage of blood coagulation. Because FXIII has also been shown to modulate inflammation and endothelial permeability, we hypothesized that FXIII diminishes multipl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf661065f44d142bd1933334c1532cf
https://europepmc.org/articles/PMC3024715/

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ELIMINATION OF C5AR PREVENTS INTESTINAL MUCOSAL DAMAGE AND ATTENUATES NEUTROPHIL INFILTRATION IN LOCAL AND REMOTE ORGANS

Autor: Qi Lu, John H. Zhang, Xiaoman Yang, Yang Cao, Sergey B. Zaets, Harini Rajan, Nancy Bogdan, Da-Zhong Xu, Ruihua Chen, Edwin A. Deitch, Eleonora Feketova

The complement C5a pathway has been shown to be an important mediator of inflammation and tissue injury. To further understand the role of C5a receptor (C5aR) pathway in ischemia/reperfusion (I/R) injury, and to evaluate the potential of antagonizing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817855c94760e7a44a6262ca4e05bf2c
https://europepmc.org/articles/PMC3024711/

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