Up-regulation of miR-146b and Down-regulation of miR-200b Contribute to the Cytotoxic Effect of Histone Deacetylase Inhibitors on ras-Transformed Thyroid Cells

Autor: Eleonora Borbone, Carlo M. Croce, Alfredo Fusco, Lucia Altucci, Mariarosaria De Rosa, Diletta Siciliano

Publikováno v: The Journal of clinical endocrinology and metabolism (2013).
info:cnr-pdr/source/autori:Borbone E, De Rosa M, Siciliano D, Altucci L, Croce CM, Fusco A./titolo:Up-regulation of miR-146b and down-regulation of miR-200b contribute to the cytotoxic effect of Histone deacetylase inhibitors on ras-transformed thyroid cells./doi:/rivista:The Journal of clinical endocrinology and metabolism/anno:2013/pagina_da:/pagina_a:/intervallo_pagine:/volume

Context:Histone deacetylase inhibitors (HDACis) are anti-cancer agents that inhibit tumor cell growth and/or survival. However, their mechanism of action remains largely undefined. Recently, we have demonstrated that HDAC inhibitors induce apoptosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc2f928078b7f008519f84c1736bbd7
http://hdl.handle.net/11588/574422

The impairment of the High Mobility Group A (HMGA) protein function contributes to the anticancer activity of trabectedin

Autor: Roberta Frapolli, Dario Palmieri, Roberto Pacelli, Maurizio D'Incalci, Sarah Uboldi, Eleonora Borbone, Daniela D'Angelo, Alfredo Fusco, Francesco Esposito

Trabectedin (Ecteinascidin-743 or ET-743) is a novel antitumour agent of marine origin with potent antitumour activity both in vitro and in vivo . It interacts with the minor groove of DNA, interfering with transcriptional activity and DNA repair pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a9406c1ce71cf005d52dbbe7d2ed8c
http://hdl.handle.net/11588/574433

Down-Regulation of the miR-25 and miR-30d Contributes to the Development of Anaplastic Thyroid Carcinoma Targeting the Polycomb Protein EZH2

Autor: Mara Tornincasa, Francesco Esposito, Eleonora Borbone, Pierlorenzo Pallante, Giovanna Maria Pierantoni, Alfredo Fusco, Antonella Federico

Publikováno v: The Journal of clinical endocrinology and metabolism 97 (2012): E710–E718. doi:10.1210/jc.2011-3068
info:cnr-pdr/source/autori:Esposito, Francesco; Tornincasa, Mara; Pallante, Pierlorenzo; Federico, Antonella; Borbone, Eleonora; Pierantoni, Giovanna Maria; Fusco, Alfredo/titolo:Down-Regulation of the miR-25 and miR-30d Contributes to the Development of Anaplastic Thyroid Carcinoma Targeting the Polycomb Protein EZH2/doi:10.1210%2Fjc.2011-3068/rivista:The Journal of clinical endocrinology and metabolism/anno:2012/pagina_da:E710/pagina_a:E718/intervallo_pagine:E710–E718/volume:97

Context:We have previously demonstrated that a set of micro-RNA (miRNA) is significantly down-regulated in anaplastic thyroid carcinomas with respect to normal thyroid tissues and to differentiated thyroid carcinomas.Objective:The objective was to ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891967acb9a9c12894f9acb9a08a6351
http://hdl.handle.net/11588/433700

miR-191 Down-Regulation Plays a Role in Thyroid Follicular Tumors through CDK6 Targeting

Autor: Marianna Colamaio, Daniela Califano, Gennaro Chiappetta, Mimma Bianco, Eleonora Borbone, Pierlorenzo Pallante, Sabrina Battista, Alfredo Fusco, Lucia Russo, Giancarlo Troncone, Antonella Federico

Publikováno v: The Journal of clinical endocrinology and metabolism 96 (2011): E1915–E1924. doi:10.1210/jc.2011-0408
info:cnr-pdr/source/autori:Colamaio, Marianna; Borbone, Eleonora; Russo, Lucia; Bianco, Mimma; Federico, Antonella; Califano, Daniela; Chiappetta, Gennaro; Pallante, Pierlorenzo; Troncone, Giancarlo; Battista, Sabrina; Fusco, Alfredo/titolo:miR-191 Down-Regulation Plays a Role in Thyroid Follicular Tumors through CDK6 Targeting/doi:10.1210%2Fjc.2011-0408/rivista:The Journal of clinical endocrinology and metabolism/anno:2011/pagina_da:E1915/pagina_a:E1924/intervallo_pagine:E1915–E1924/volume:96

CONTEXT: Well-differentiated thyroid carcinomas include papillary (PTC) and follicular (FTC) carcinomas. FTC is usually a more aggressive form of cancer than the more common papillary type. miR-191 expression is frequently altered in several neoplasi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf1034df5342420eaaed33c8d257345

Histone deacetylase inhibitors induce thyroid cancer-specific apoptosis through proteasome-dependent inhibition of TRAIL degradation

Autor: Maria Teresa Berlingieri, Eleonora Borbone, Antonello Mai, Giovanni Chiappetta, F De Bellis, Angela Nebbioso, Alfredo Fusco, Lucia Altucci

Publikováno v: Oncogene (Basingstoke) (2009).
info:cnr-pdr/source/autori:Borbone E, Berlingieri MT, De Bellis F, Nebbioso A, Chiappetta G, Mai A, Altucci L, Fusco A./titolo:Histone deacetylase inhibitors induce thyroid cancer-specific apoptosis through proteasome-dependent inhibition of TRAIL degradation./doi:/rivista:Oncogene (Basingstoke)/anno:2009/pagina_da:/pagina_a:/intervallo_pagine:/volume
Oncogene (Basingstoke) 29 (2010): 105–116. doi:10.1038/onc.2009.306
info:cnr-pdr/source/autori:Borbone E 123, Berlingieri MT 1, De Bellis F 4, Nebbioso A 4, Chiappetta G 5, Mai A 6, Altucci L 4, Fusco A.123/titolo:Histone deacetylase inhibitors induce thyroid cancer-specific apoptosis through proteasome-dependent inhibition of TRAIL degradation./doi:10.1038%2Fonc.2009.306/rivista:Oncogene (Basingstoke)/anno:2010/pagina_da:105/pagina_a:116/intervallo_pagine:105–116/volume:29

Anaplastic thyroid carcinoma (ATC) is considered one of the most aggressive malignancies, having a poor prognosis and being refractory to conventional chemotherapy and radiotherapy. Alteration in histone deacetylase (HDAC) activity has been reported

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de312139f699b3082b733a127863371d
https://publications.cnr.it/doc/21189