Výsledky vyhledávání - "Eleonora Elhalem"

Design, Synthesis, and Characterization of Novel sn-1 Heterocyclic DAG-Lactones as PKC Activators

Autor: Mariana Cooke, Eleonora Elhalem, Marcelo G. Kazanietz, Ana Bellomo, Antonella Scravaglieri, Larry V. Pearce, Maria Julieta Comin, Megan L. Peach, Lucía Gandolfi Donadío

Publikováno v: Journal of Medicinal Chemistry. 64:11418-11431

DAG-lactones represent useful templates for the design of potent and selective C1 domain ligands for PKC isozymes. The ester moiety at the sn-1 position, a common feature in this template, is relevant for C1 domain interactions, but it represents a l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4b945efbd8a3199dab081038433fcf7
https://doi.org/10.1021/acs.jmedchem.1c00739

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Design, Synthesis, and Characterization of Novel

Autor: Eleonora, Elhalem, Ana, Bellomo, Mariana, Cooke, Antonella, Scravaglieri, Larry V, Pearce, Megan L, Peach, Lucía, Gandolfi Donadío, Marcelo G, Kazanietz, María J, Comin

Publikováno v: Journal of medicinal chemistry. 64(15)

DAG-lactones represent useful templates for the design of potent and selective C1 domain ligands for PKC isozymes. The ester moiety at the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::49c93cff89a3cfdf7734d263e671a44d
https://pubmed.ncbi.nlm.nih.gov/34279947

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Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKCα, PKCε, and RasGRP

Autor: Lucía Gandolfi Donadío, James A. Kelley, Xiaoling Zhou, Lia Cynthia Garcia, Christopher C. Lai, Megan L. Peach, Nancy E. Lewin, Maria Julieta Comin, Peter M. Blumberg, Eleonora Elhalem

Publikováno v: Bioorganic & Medicinal Chemistry. 25:2971-2980

C1 domain-containing proteins, such as protein kinase C (PKC), have a central role in cellular signal transduction. Their involvement in many diseases, including cancer, cardiovascular disease, and immunological and neurological disorders has been ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ed507ec724289cb336f8d8748c1ca1
https://doi.org/10.1016/j.bmc.2017.03.022

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NMR study on the stabilization and chiral discrimination of sulforaphane enantiomers and analogues by cyclodextrins

Autor: Inmaculada Fernández, Noureddine Khiar, Rocío Recio, Juan Andrés Benito, Eleonora Elhalem

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla

Sulforaphane (SFN), a phytochemical isolated from broccoli, is an important antitumoral compound with additional beneficial effect on other important diseases. However, the chemical instability of SFN has hampered its clinical use. In order to circum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912ff4538ce6689bc5b206b10ac0e70b
https://pubmed.ncbi.nlm.nih.gov/29486836

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Synthesis and biological evaluation of N-thia-carba-thymidine as an antiherpetic agent

Autor: Juan B. Rodriguez, Eleonora Elhalem, Carlos A. Pujol, Elsa B. Damonte

Publikováno v: Tetrahedron. 66:3332-3340

As a continuation of our project aimed at the search for new antiviral agents, the synthesis and biological evaluation of N-thia-carba-thymidine ((1R,2S,4S,5S)-5-methyl-1-{6-thia-4-hydroxy-5-[(hydroxy)-methyl]bicyclo[3.1.0]hex-2-yl}-1,3-dihydropyrimi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9145d0d7a747a27fea1a53ce722f426e
https://doi.org/10.1016/j.tet.2010.02.092

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Synthetic studies toward the preparation of (4R,5R)-(−)-3-[(benzyloxy)methyl]-4,5-O-isopropylidene-cyclopenten-2-one: an important synthetic intermediate for carbanucleosides

Autor: Maria Julieta Comin, Guadalupe García-Liñares, Eleonora Elhalem, Juan B. Rodriguez, Julieta Leitofuter

Publikováno v: Tetrahedron: Asymmetry. 16:425-431

The carbocyclic compound (4R,5R)-(-)-3-[(benzyloxy)methyl]-4,5-O- isopropylidene-2-cyclopentenone 1 is an important synthetic intermediate to access a variety of carbanucleosides. Herein, synthetic studies that lead to this valuable compound employin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10828c38954e6a5768d4fed8b297c823
https://doi.org/10.1016/j.tetasy.2004.11.069

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Studies on the diastereoselective oxidation of 1-thio-β-D-glucopyranosides: synthesis of the usually less favoured RS sulfoxide as a single diastereoisomer

Autor: Inmaculada Fernández, Eleonora Elhalem, Rocío Recio, Eleuterio Álvarez, Noureddine Khiar, Juan Francisco Moya-López

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla

A detailed study on the diastereoselective oxidation of 1-thio-β-D-glucopyranosides is reported. It has been shown that the sense and the degree of stereochemical outcome of the oxidation are highly dependent on the substituent of the sulfur and on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f94e9e12230af430d6f6d9d70f52b2
http://hdl.handle.net/10261/110757

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Design and Synthesis of Aryloxyethyl Thiocyanate Derivatives as Potent Inhibitors ofTrypanosoma cruziProliferation

Autor: Sergio H. Szajnman, Juan B. Rodriguez, Eleonora Elhalem, Wen Yan, Brian N. Bailey, Roberto Docampo

Publikováno v: Journal of Medicinal Chemistry. 43:1826-1840

As a part of our project directed at the search of new chemotherapeutic agents against American trypanosomiasis (Chagas' disease), several drugs possessing the 4-phenoxyphenoxy skeleton and other closely related structures employing the thiocyanate m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39e43075625600d74a15ecb857a6646
https://doi.org/10.1021/jm9905007

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Sulforaphane homologues: Enantiodivergent synthesis of both enantiomers, activationof the Nrf2 transcription factor and selective cytotoxic activity

Autor: Inmaculada Fernández, Franziska Lieder, Noureddine Khiar, Sabine Werner, Miguel López-Lázaro, José Manuel Calderón-Montaño, Eleonora Elhalem, Rocío Recio

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla

Reported is an enantiodivergent approach for the synthesis of both enantiomers of sulforaphane (SFN) homologues with different chain lengths between the sulfinyl sulfur and the isothiocyanate groups and different substituents on the sulfinyl sulfur.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34a8d82170c5592d88e817843c68907

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Proline-coated gold nanoparticles as a highly efficient nanocatalyst for the enantioselective direct aldol reaction in water

Autor: Victoria Valdivia, Inmaculada Fernández, Eleonora Elhalem, Raquel Navas, Noureddine Khiar

Publikováno v: idUS. Depósito de Investigación de la Universidad de Sevilla
instname

Reported is an efficient approach to the synthesis of water-soluble proline-coated gold nanoparticles through a place exchange reaction between pentanethiolate stabilized gold nanoparticles and a proline-tethered amphiphilic thiol. Preliminary studie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84031ffd7b06489fb89a4491285e7665
https://idus.us.es/xmlui/handle/11441/42702

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