scMuffin: an R package to disentangle solid tumor heterogeneity by single-cell gene expression analysis

Autor: Valentina Nale, Alice Chiodi, Noemi Di Nanni, Ingrid Cifola, Marco Moscatelli, Cinzia Cocola, Matteo Gnocchi, Eleonora Piscitelli, Ada Sula, Ileana Zucchi, Rolland Reinbold, Luciano Milanesi, Alessandra Mezzelani, Paride Pelucchi, Ettore Mosca

Publikováno v: BMC Bioinformatics, Vol 24, Iss 1, Pp 1-18 (2023)

Abstract Introduction Single-cell (SC) gene expression analysis is crucial to dissect the complex cellular heterogeneity of solid tumors, which is one of the main obstacles for the development of effective cancer treatments. Such tumors typically con

Externí odkaz: https://doaj.org/article/f5fb666a746d4a0c9efa37c72f66cf11

Transmembrane Protein TMEM230, a Target of Glioblastoma Therapy

Autor: Cinzia Cocola, Valerio Magnaghi, Edoardo Abeni, Paride Pelucchi, Valentina Martino, Laura Vilardo, Eleonora Piscitelli, Arianna Consiglio, Giorgio Grillo, Ettore Mosca, Roberta Gualtierotti, Daniela Mazzaccaro, Gina La Sala, Chiara Di Pietro, Mira Palizban, Sabino Liuni, Giuseppina DePedro, Stefano Morara, Giovanni Nano, James Kehler, Burkhard Greve, Alessio Noghero, Daniela Marazziti, Federico Bussolino, Gianfranco Bellipanni, Igea D’Agnano, Martin Götte, Ileana Zucchi, Rolland Reinbold

Publikováno v: Frontiers in Cellular Neuroscience, Vol 15 (2021)

Glioblastomas (GBM) are the most aggressive tumors originating in the brain. Histopathologic features include circuitous, disorganized, and highly permeable blood vessels with intermittent blood flow. These features contribute to the inability to dir

Externí odkaz: https://doaj.org/article/75f0ce9fbf4943ef8b3abd80f17950d9

The heparan sulfate proteoglycan syndecan‐1 regulates colon cancer stem cell function via a focal adhesion kinase—Wnt signaling axis

Autor: Valeria Tria, Rolland Reinbold, George W. Yip, Wey-Cheng Sim, Sherif Abdelaziz Ibrahim, Ileana Zucchi, Burkhard Greve, Sampath Kumar Katakam, Theodoros Karnavas, Martin Götte, Stefano Molgora, Paride Pelucchi, Eleonora Piscitelli, Eslam A. El-Ghonaimy

Publikováno v: The FEBS Journal
The FEBS journal
(2020). doi:10.1111/febs.15356
info:cnr-pdr/source/autori:Katakam, Sampath Kumar; Tria, Valeria; Sim, Wey-Cheng; Yip, George W.; Molgora, Stefano; Karnavas, Theodoros; Elghonaimy, Eslam A.; Pelucchi, Paride; Piscitelli, Eleonora; Ibrahim, Sherif Abdelaziz; Zucchi, Ileana; Reinbold, Rolland; Greve, Burkhard; Goette, Martin/titolo:The heparan sulfate proteoglycan syndecan-1 regulates colon cancer stem cell function via a focal adhesion kinase-Wnt signaling axis/doi:10.1111%2Ffebs.15356/rivista:The FEBS journal (Print)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume

In colon cancer, downregulation of the transmembrane heparan sulfate proteoglycan syndecan-1 (Sdc-1) is associated with increased invasiveness, metastasis, and dedifferentiation. As Sdc-1 modulates signaling pathways relevant to stem cell function, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ea4b24fab851ea7f018baf542f61c0
https://doi.org/10.1111/febs.15356

Integrating microstructured electrospun scaffolds in an open microfluidic system for in vitro studies of human patient-derived primary cells

Autor: Valentina Cirillo, Diego Repetto, Ioannis Missitzis, Luigi Ambrosio, Giovanni Bertalot, Denise Pezzuoli, Ugo Valbusa, Rolland Reinbold, Valentina Martino, Angelos D. Gritzapis, Gianfranco Bellipanni, Marica Marrese, Patrizia Guida, Paride Pelucchi, Martin Götte, Giuseppe Firpo, Vincenzo Guarino, Elena Angeli, Theodoros Karnavas, Giovanni Porta, Luca Repetto, Marietta D’Albore, Cinzia Cocola, Ileana Zucchi, Eleonora Piscitelli

Publikováno v: ACS biomaterials science & engineering 6 (2020): 3649–3663. doi:10.1021/acsbiomaterials.0c00352
info:cnr-pdr/source/autori:Guida P.; Piscitelli E.; Marrese M.; Martino V.; Cirillo V.; Guarino V.; Angeli E.; Cocola C.; Pelucchi P.; Repetto L.; Firpo G.; Karnavas T.; Gotte M.; Gritzapis A.; D'Albore M.; Repetto D.; Pezzuoli D.; Missitzis I.; Porta G.; Bertalot G.; Bellipanni G.; Zucchi I.; Ambrosio L.; Valbusa U.; Reinbold R.A./titolo:Integrating microstructured electrospun scaffolds in an open microfluidic system for in vitro studies of human patient-derived primary cells/doi:10.1021%2Facsbiomaterials.0c00352/rivista:ACS biomaterials science & engineering/anno:2020/pagina_da:3649/pagina_a:3663/intervallo_pagine:3649–3663/volume:6

Recent studies have suggested that microenvironmental stimuli play a significant role in regulating cellular proliferation and migration, as well as in modulating self-renewal and differentiation processes of mammary cells with stem cell (SCs) proper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0080112bb76d3d035f37dc14ee7787e
http://hdl.handle.net/11383/2131583

FGF2 and EGF Are Required for Self-Renewal and Organoid Formation of Canine Normal and Tumor Breast Stem Cells

Autor: Brian M. Gray, Luciano Milanesi, Stefano Molgora, Gianfranco Bellipanni, Cinzia Cocola, Gaia Cecilia Luvoni, James Kehler, Rolland Reinbold, Mariacristina Crosti, Ileana Zucchi, Valeria Grieco, Cinzia Bragato, Antonio Giordano, Maria Cristina Veronesi, Monica Moro, Marianna Greco, Eleonora Piscitelli

Publikováno v: Journal of Cellular Biochemistry. 118:570-584

Recent studies suggest that human tumors are generated from cancer cells with stem cell (SC) properties. Spontaneously occurring cancers in dogs contain a diversity of cells that like for human tumors suggest that certain canine tumors are also gener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3352ca5f548f4939eefd37cf5755e3f6
https://doi.org/10.1002/jcb.25737