Výsledky vyhledávání - "Eleonora, Cescon"

Akademický článek

'Dual Anta-Inhibitors' of the A2A Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies

Autor: Andrea Spinaci, Michela Buccioni, Daniela Catarzi, Chang Cui, Vittoria Colotta, Diego Dal Ben, Eleonora Cescon, Beatrice Francucci, Ilenia Grieco, Catia Lambertucci, Gabriella Marucci, Davide Bassani, Matteo Pavan, Flavia Varano, Stephanie Federico, Giampiero Spalluto, Stefano Moro, Rosaria Volpini

Publikováno v: Pharmaceuticals, Vol 16, Iss 2, p 167 (2023)

Based on a screening of a chemical library of A2A adenosine receptor (AR) antagonists, a series of di- and tri-substituted adenine derivatives were synthesized and tested for their ability to inhibit the activity of the enzyme casein kinase 1 delta (

Externí odkaz: https://doaj.org/article/1f850dd815cb47c18c31a8c7ecb2492f

Zobrazit plný text záznamu

Plný text ve formátu HTML

{\textquotedblleft}Dual Anta-Inhibitors{\textquotedblright} of the A2A Adenosine Receptor and Casein Kinase {CK}1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies

Autor: Andrea, Spinaci, Michela, Buccioni, Daniela, Catarzi, Chang, Cui, Vittoria, Colotta, Diego Dal Ben, Eleonora, Cescon, Beatrice, Francucci, Ilenia, Grieco, Catia, Lambertucci, Gabriella, Marucci, Bassani, Davide, Pavan, Matteo, Flavia, Varano, Stephanie, Federico, Giampiero, Spalluto, Moro, Stefano, Rosaria, Volpini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3657::04f30cf1fb13eb226d665596b83a9386
https://hdl.handle.net/11577/3469385

Zobrazit plný text záznamu

Glycogen Synthase Kinase 3β Involvement in Neuroinflammation and Neurodegenerative Diseases

Autor: Teresa Gianferrara, Eleonora Cescon, Ilenia Grieco, Giampiero Spalluto, Stephanie Federico

Background:GSK-3β activity has been strictly related to neuroinflammation and neurodegeneration. Alzheimer’s disease is the most studied neurodegenerative disease, but GSK-3β seems to be involved in almost all neurodegenerative diseases, includin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4082858fd69b7e4ceea5d896cefe16c2
https://hdl.handle.net/11368/3035111

Zobrazit plný text záznamu

A Computational Workflow for the Identification of Novel Fragments Acting as Inhibitors of the Activity of Protein Kinase CK1δ

Autor: Mattia Sturlese, Maicol Bissaro, Davide Bassani, Stephanie Federico, Eleonora Cescon, Stefano Moro, Giovanni Bolcato, Giampiero Spalluto, Matteo Pavan

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 18
International Journal of Molecular Sciences, Vol 22, Iss 9741, p 9741 (2021)

Fragment-Based Drug Discovery (FBDD) has become, in recent years, a consolidated approach in the drug discovery process, leading to several drug candidates under investigation in clinical trials and some approved drugs. Among these successful applica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082671a93fc35e3a7ed79dc5a818905b
https://www.mdpi.com/1422-0067/22/18/9741

Zobrazit plný text záznamu

Scaffold Repurposing of in-House Chemical Library toward the Identification of New Casein Kinase 1 δinhibitors

Autor: Gianpiero Spalluto, Alice Valentini, Maicol Bissaro, Mattia Sturlese, Stefano Moro, Maria Grazia Ferlin, Stephanie Federico, Eleonora Cescon, Giovanni Bolcato

Publikováno v: ACS Med Chem Lett

[Image: see text] Recent studies have highlighted the key role of Casein kinase 1 δ (CK1δ) in the development of several neurodegenerative pathologies, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e389b24b092bc7b50d16f764e8729717
http://hdl.handle.net/11577/3349043

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání