Výsledky vyhledávání - "Eleni Panagioti"

Akademický článek

Clinical implications of cytomegalovirus in glioblastoma progression and therapy

Autor: Noe B. Mercado, Jacqueline N. Real, Jacob Kaiserman, Eleni Panagioti, Charles H. Cook, Sean E. Lawler

Publikováno v: npj Precision Oncology, Vol 8, Iss 1, Pp 1-11 (2024)

Abstract Glioblastoma (GBM) is one of the deadliest brain cancers with a median survival of only 15 months. This poor prognosis has prompted exploration of novel therapeutic targets for GBM patients. Human cytomegalovirus (HCMV) has been implicated i

Externí odkaz: https://doaj.org/article/018f7697d6444b4abc5f1b05d01732e2

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Akademický článek

Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

BackgroundThe GL261 and CT2A syngeneic tumor lines are frequently used as immunocompetent orthotopic mouse models of human glioblastoma (huGBM) but demonstrate distinct differences in their responses to immunotherapy.MethodsTo decipher the cell-intri

Externí odkaz: https://doaj.org/article/0d4ef411871943b490bc6d2c4f558fb2

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Akademický článek

Preclinical safety assessment of MV-s-NAP, a novel oncolytic measles virus strain armed with an H. pylori immunostimulatory bacterial transgene

Autor: Kimberly B. Viker, Michael B. Steele, Ianko D. Iankov, Susanna C. Concilio, Arun Ammayappan, Brad Bolon, Nathan J. Jenks, Matthew P. Goetz, Eleni Panagioti, Mark J. Federspiel, Minetta C. Liu, Kah Whye Peng, Evanthia Galanis

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 532-546 (2022)

Despite recent therapeutic advances, metastatic breast cancer (MBC) remains incurable. Engineered measles virus (MV) constructs based on the attenuated MV Edmonston vaccine platform have demonstrated significant oncolytic activity against solid tumor

Externí odkaz: https://doaj.org/article/57a8d49639d54665a6d7814a47ceb75e

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Akademický článek

Live Attenuated Measles Virus Vaccine Expressing Helicobacter pylori Heat Shock Protein A

Autor: Ianko D. Iankov, Cheyne Kurokawa, Kimberly Viker, Steven I. Robinson, Arun Ammayappan, Eleni Panagioti, Mark J. Federspiel, Evanthia Galanis

Publikováno v: Molecular Therapy: Oncolytics, Vol 19, Iss , Pp 136-148 (2020)

Measles virus (MV) Edmonston derivative strains are attractive vector platforms in vaccine development and oncolytic virotherapy. Helicobacter pylori heat shock protein A (HspA) is a bacterial heat shock chaperone with essential function as a Ni-ion

Externí odkaz: https://doaj.org/article/68e91f8905c648be95292648fbd4d1a1

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Akademický článek

Demarcated thresholds of tumor-specific CD8 T cells elicited by MCMV-based vaccine vectors provide robust correlates of protection

Autor: Elham Beyranvand Nejad, Robert B. Ratts, Eleni Panagioti, Christine Meyer, Jennifer D. Oduro, Luka Cicin-Sain, Klaus Früh, Sjoerd H. van der Burg, Ramon Arens

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-17 (2019)

Abstract Background The capacity of cytomegalovirus (CMV) to elicit long-lasting strong T cell responses, and the ability to engineer the genome of this DNA virus positions CMV-based vaccine vectors highly suitable as a cancer vaccine platform. Defin

Externí odkaz: https://doaj.org/article/9a0739e7a5214c78a3304101c5cb7652

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Akademický článek

Cytomegalovirus infection exacerbates autoimmune mediated neuroinflammation

Autor: Marjan Vanheusden, Bieke Broux, Suzanne P. M. Welten, Liesbet M. Peeters, Eleni Panagioti, Bart Van Wijmeersch, Veerle Somers, Piet Stinissen, Ramon Arens, Niels Hellings

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Abstract Cytomegalovirus (CMV) is a latent virus which causes chronic activation of the immune system. Here, we demonstrate that cytotoxic and pro-inflammatory CD4+CD28null T cells are only present in CMV seropositive donors and that CMV-specific Imm

Externí odkaz: https://doaj.org/article/3fd87ea4885746a9880b7294e7de70e8

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Akademický článek

Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections

Autor: Eleni Panagioti, Paul Klenerman, Lian N. Lee, Sjoerd H. van der Burg, Ramon Arens

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

For many years, the focus of prophylactic vaccines was to elicit neutralizing antibodies, but it has become increasingly evident that T cell-mediated immunity plays a central role in controlling persistent viral infections such as with human immunode

Externí odkaz: https://doaj.org/article/ee47ca5542c94777978e937406ce06c4

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Akademický článek

The Breadth of Synthetic Long Peptide Vaccine-Induced CD8+ T Cell Responses Determines the Efficacy against Mouse Cytomegalovirus Infection.

Autor: Eleni Panagioti, Anke Redeker, Suzanne van Duikeren, Kees Lmc Franken, Jan Wouter Drijfhout, Sjoerd H van der Burg, Ramon Arens

Publikováno v: PLoS Pathogens, Vol 12, Iss 9, p e1005895 (2016)

There is an ultimate need for efficacious vaccines against human cytomegalovirus (HCMV), which causes severe morbidity and mortality among neonates and immunocompromised individuals. In this study we explored synthetic long peptide (SLP) vaccination

Externí odkaz: https://doaj.org/article/cd937639b4a94516848a65de40877560

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