SARS-CoV-2 lineage B.1.1.7 is associated with greater disease severity among hospitalised women but not men: multicentre cohort study

Autor: Judith Breuer, Catherine F Houlihan, Nick Freemantle, David Partridge, Gaia Nebbia, Jacqui Prieto, Gee Yen Shin, Andrew Copas, Oliver Stirrup, Kenneth Laing, Rachel Williams, Helen Wheeler, Paul Randell, Ana da Silva Filipe, Maria-Teresa Cutino-Moguel, Tommy Rampling, Tabassum Khan, James Price, Eleni Nastouli, Katie Johnson, Sharon Glaysher, Scott Elliott, Helen Umpleby, Emanuela Pelosi, Emma Thomson, Cristina Venturini, Anna Riddell, Alison Cox, Andrew C Hayward, Malin Bergström, David Harrington, Charlotte Williams, Tanzina Haque, Dianne Irish, Adrienn Angyal, Marios Margaritis, Moira Spyer, Florencia Boshier, José Afonso Guerra-Assunção, Adela Alcolea-Medina, Angela Beckett, Themoula Charalampous, Raghavendran Kulasegaran Shylini, Beatrix Kele, Irene Monahan, Guy Mollett, Matthew Parker, Sunando Roy, Joshua Taylor, Sophie Weller, Eleri Wilson-Davies, Phillip Wade, Joseph Hughes, Tabitha Mahungu, Cassie Pope, Samuel Robson, Kordo Saeed, Thushan de Silva, Luke Snell, Adam A Witney, James Blackstone, Leanne Hockey, Georgia Marley, Christine Peters, Flavia Flaviani, Bindi Patel, Tom G S Williams, Rahul Batra, Jonathan D Edgeworth, Pinglawathee Madona, Jennifer Hart, Juanita Pang, Helena Tutill, Nadua Bayzid, Marius Cotic, Luke Green, Benjamin Lindsey, Amy State, Alison Cope, Peijun Zhang, Max Whiteley, Marta Gallis Ramalho, Stella Christou, Stavroula Louka, Hailey Hornsby, Benjamin Foulkes, Paige Wolverson, Joe Heffer, Nikki Smith, Salman Goudarzi, Chris Fearn, Kate Cook, Katie Loveson, Adhyana Mahamana, Buddhini Samaraweera, Siona Silveira, Stephen Aplin, Sarah Jeremiah, Matthew Harvey, Thea Sass, Ngee Keong Tan, Claudia Cardoso Pereira, Dan Frampton, Matt Byott, Judith Heaney, Emilie Sanchez, Stavroula M Paraskevopoulou

Publikováno v: BMJ Open Respiratory Research, Vol 8, Iss 1 (2021)

Background SARS-CoV-2 lineage B.1.1.7 has been associated with an increased rate of transmission and disease severity among subjects testing positive in the community. Its impact on hospitalised patients is less well documented.Methods We collected v

Externí odkaz: https://doaj.org/article/8a895e04928046eab408c7338ade581c

Eyeglasses and risk of COVID-19 transmission—analysis of the Virus Watch Community Cohort study

Autor: Annalan M.D. Navaratnam, Christopher O'Callaghan, Sarah Beale, Vincent Nguyen, Anna Aryee, Isobel Braithwaite, Thomas E. Byrne, Wing Lam Erica Fong, Ellen Fragaszy, Cyril Geismar, Susan Hoskins, Jana Kovar, Parth Patel, Madhumita Shrotri, Sophie Weber, Alexei Yavlinsky, Robert W. Aldridge, Andrew C. Hayward, Susan Michie, Pia Hardelid, Linda Wijlaars, Eleni Nastouli, Moira Spyer, Ben Killingley, Ingemar Cox, Vasileios Lampos, Rachel A. McKendry, Tao Cheng, Yunzhe Liu, Jo Gibbs, Richard Gilson, Alison Rogers, Anne M. Johnson

Publikováno v: International Journal of Infectious Diseases, Vol 139, Iss , Pp 28-33 (2024)

Objectives: The importance of SARS-CoV-2 transmission via the eyes is unknown, with previous studies mainly focusing on protective eyewear in healthcare settings. This study aimed to test the hypothesis that wearing eyeglasses is associated with a lo

Externí odkaz: https://doaj.org/article/226649ca8e6243bba90a57f7163b122c

Low unspliced cell-associated HIV RNA in early treated adolescents living with HIV on long suppressive ART

Autor: Kathleen Gärtner, Sara Domínguez-Rodríguez, Judith Heaney, Triantafylia Gkouleli, Paul Grant, Karim Dorgham, Delphine Sauce, Cathia Soulie, Eloise J. Busby, Denise M. O’Sullivan, Moira Spyer, Johannes C. Botha, Maria Angeles Muñoz-Fernandez, Alfredo Tagarro, Nicola Cotugno, Jim F. Huggett, Nigel Klein, Paolo Palma, Pablo Rojo Conejo, Caroline Foster, Carlo Giaquinto, Paolo Rossi, Deborah Persaud, Anita De Rossi, Anne-Geneviève Marcelin, Eleni Nastouli

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionInitiation of antiretroviral treatment (ART) in patients early after HIV-infection and long-term suppression leads to low or undetectable levels of HIV RNA and cell-associated (CA) HIV DNA and RNA. Both CA-DNA and CA-RNA, overestimate the

Externí odkaz: https://doaj.org/article/4ff5de9e0e7d46feaef69aac5332bac4

Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK [version 2; peer review: 2 approved]

Autor: Eleni Nastouli, Eleanor Barnes, Graham S. Cooke, Cori Campbell, Theresa Noble, David A. Smith, Steve Harris, Kinga A Várnai, Gail Roadknight, Hizni Salih, Ben Glampson, Stephanie Little, Dimitri Papadimitriou, Paul Klenerman, Luca Mercuri, Vince Taylor, Christopher R Jones, Hang Phan, Afzal Chaudhry, Josune Olza, Florina Borca, Luis Romão, Frazer Warricker, Louise English, David Ramlakhan, Monique I. Andersson, Salim I. Khakoo, Jane Collier, Philippa C. Matthews, Kerrie Woods, William Gelson, Tingyan Wang, Oliver Freeman, Jim Davies

Publikováno v: Wellcome Open Research, Vol 7 (2023)

Background To determine the impact of the COVID-19 pandemic on the population with chronic Hepatitis B virus (HBV) infection under hospital follow-up in the UK, we quantified the coverage and frequency of measurements of biomarkers used for routine s

Externí odkaz: https://doaj.org/article/c0516a624eaf4e1986582e7833115042

Nucleocapsid and spike antibody responses following virologically confirmed SARS-CoV-2 infection: an observational analysis in the Virus Watch community cohort

Autor: Annalan M D Navaratnam, Madhumita Shrotri, Vincent Nguyen, Isobel Braithwaite, Sarah Beale, Thomas E Byrne, Wing Lam Erica Fong, Ellen Fragaszy, Cyril Geismar, Susan Hoskins, Jana Kovar, Parth Patel, Alexei Yavlinsky, Anna Aryee, Alison Rodger, Andrew C Hayward, Robert W Aldridge, Susan Michie, Pia Hardelid, Linda Wijlaars, Eleni Nastouli, Moira Spyer, Ben Killingley, Ingemar Cox, Vasileios Lampos, Rachel A McKendry, Tao Cheng, Yunzhe Liu, Jo Gibbs, Richard Gilson, Anne M Johnson

Publikováno v: International Journal of Infectious Diseases, Vol 123, Iss , Pp 104-111 (2022)

Objectives: Seroprevalence studies can provide a measure of SARS-CoV-2 cumulative incidence, but a better understanding of spike and nucleocapsid (anti-N) antibody dynamics following infection is needed to assess the longevity of detectability. Metho

Externí odkaz: https://doaj.org/article/8cb29b22a2e64be8b2e7cef278f83f53