Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis

Autor: Irfete S. Fetahu, Wolfgang Esser-Skala, Rohit Dnyansagar, Samuel Sindelar, Fikret Rifatbegovic, Andrea Bileck, Lukas Skos, Eva Bozsaky, Daria Lazic, Lisa Shaw, Marcus Tötzl, Dora Tarlungeanu, Marie Bernkopf, Magdalena Rados, Wolfgang Weninger, Eleni M. Tomazou, Christoph Bock, Christopher Gerner, Ruth Ladenstein, Matthias Farlik, Nikolaus Fortelny, Sabine Taschner-Mandl

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Abstract Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood tumor has been molecularly defined at the primary cancer site, however, the bone marrow (BM) as the metastatic niche of NB is poorly characterized. Here

Externí odkaz: https://doaj.org/article/117133ab2f214dc88c7d58fa27ea3acd

Sarcoma treatment in the era of molecular medicine

Autor: Thomas GP Grünewald, Marta Alonso, Sofia Avnet, Ana Banito, Stefan Burdach, Florencia Cidre‐Aranaz, Gemma Di Pompo, Martin Distel, Heathcliff Dorado‐Garcia, Javier Garcia‐Castro, Laura González‐González, Agamemnon E Grigoriadis, Merve Kasan, Christian Koelsche, Manuela Krumbholz, Fernando Lecanda, Silvia Lemma, Dario L Longo, Claudia Madrigal‐Esquivel, Álvaro Morales‐Molina, Julian Musa, Shunya Ohmura, Benjamin Ory, Miguel Pereira‐Silva, Francesca Perut, Rene Rodriguez, Carolin Seeling, Nada Al Shaaili, Shabnam Shaabani, Kristina Shiavone, Snehadri Sinha, Eleni M Tomazou, Marcel Trautmann, Maria Vela, Yvonne MH Versleijen‐Jonkers, Julia Visgauss, Marta Zalacain, Sebastian J Schober, Andrej Lissat, William R English, Nicola Baldini, Dominique Heymann

Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 11, Pp 1-33 (2020)

Abstract Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and compr

Externí odkaz: https://doaj.org/article/32421af97ff64f339c73c8bfd6f57409

Figure S2 from Quantification of Translocation-Specific ctDNA Provides an Integrating Parameter for Early Assessment of Treatment Response and Risk Stratification in Ewing Sarcoma

Autor: Markus Metzler, Uta Dirksen, Wolfgang Hartmann, Tobias Bäuerle, Abbas Agaimy, Eleni M. Tomazou, Peter Peneder, Adrian M Stütz, Christian Schmidkonz, Jakob Zierk, Andreas Ranft, Johanna Eiblwieser, Manuela Krumbholz

Event-free survival (EFS) and overall survival (OS) by sex, age at diagnosis, pelvis localization, tumor volume, presence of metastases, and histological response in patients with EWS.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4dbfb3f2d0ccbb401845a07c7fd8be
https://doi.org/10.1158/1078-0432.22481355

High-content drug screening in zebrafish xenografts reveals high efficacy of dual MCL-1/BCL-X

Autor: Sarah, Grissenberger, Caterina, Sturtzel, Andrea, Wenninger-Weinzierl, Branka, Radic-Sarikas, Eva, Scheuringer, Lisa, Bierbaumer, Vesnie, Etienne, Fariba, Némati, Susana, Pascoal, Marcus, Tötzl, Eleni M, Tomazou, Martin, Metzelder, Eva M, Putz, Didier, Decaudin, Olivier, Delattre, Didier, Surdez, Heinrich, Kovar, Florian, Halbritter, Martin, Distel

Publikováno v: Cancer letters. 554

Ewing sarcoma is a pediatric bone and soft tissue cancer with an urgent need for new therapies to improve disease outcome. To identify effective drugs, phenotypic drug screening has proven to be a powerful method, but achievable throughput in mouse x

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f4d14e7da1850327c2861d6bd66a4bcd
https://pubmed.ncbi.nlm.nih.gov/36462556

Contributors

Autor: Carlos Ferrer Albiach, C. Alix-Panabières, Fernanda Amary, Andrea Angelini, Gustavo A. Arias-Pinilla, Hector M. Arredondo Carrera, Sofia Avnet, Dominic Bagguley, Nicola Baldini, Jean-Yves Blay, Claudine Blin-Wakkach, Edith Bonnelye, Corinne Bouvier, J.V.M.G. Bovée, Mehdi Brahmi, Janet Brown, Thomas J. Brown, Janet E. Brown, Ø.S. Bruland, Teresa Piquer Camañes, Preston Campbell, Giovana Carrasco, Daniel Chappard, Michael M. Chau, Edward Chow, Dimitrios Christoulas, Anne-Marie Cleton-Jansen, Philippe Clézardin, Denis R. Clohisy, Denis Cochonneau, Robert Coleman, Nadege Corradini, Ovidiu Daescu, Heike Daldrup-Link, Dylan C. Dean, Gonzague de Pinieux, Zhenfeng Duan, Armelle Dufresne, Maryne Dupuy, A. Dutour, Claire M. Edwards, Jouglar Emmanuel, Fei Fei, Adrienne M. Flanagan, null Florent Elefteriou, Ramses Forsyth, Pierrick G.J. Fournier, Stefano Gambera, Dingcheng Gao, Javier García-Castro, Christopher George, Steven Georges, Anne Gomez-Brouchet, Francois Gouin, Agamemnon E. Grigoriadis, Arwin Groenewoud, Thomas G.P. Grünewald, Julia Halper, Yujiao Han, Shuko Harada, Jendrik Hardes, Jiri Hatina, Marie-Francoise Heymann, Dominique Heymann, David G. Hicks, L.S. Hiemcke-Jiwa, Tina Thi Ho, Pancras C.W. Hogendoorn, Ingunn Holen, Konstantin Horas, Francis J. Hornicek, Aymen I. Idris, Brenda I. Iduarte, Hakan Ilaslan, Victoria James, Prem Ruben Jayaram, Emmanuel Jouglar, Yan-Ran Joyce Wang, Patricia Juárez, A. Juzeniene, Yibin Kang, Mathijs Kint, Helen J. Knowles, Udo Kontny, Francois Lamoureux, R.H. Larsen, Mélanie Lavaud, Nathan Lawrentschuk, Michelle A. Lawson, Bénédicte Brounais Le-Royer, Patrick Leavey, Fernando Lecanda, Jiyun Lee, Mélanie Legrand, Frédéric Lézot, Shibo Li, Fiona Lim, Chun-Yu Lin, Andrej Lissat, Ana Lopez-Guajardo, Ollivier Luc, Joseph Ludwig, Jorma A. Määttä, Virginia Morillo Macías, Maria-Bernadette Madel, Paul I. Mallinson, Perrine Marec-Berard, Carina Marques, Ingrid Masson, Antonio Maurizi, Andreas F. Mavrogenis, Camila M. Melo, Sofía T. Menéndez, Nichole Michael, Himabindu Mikkilineni, Vivek Mittal, Sarah Morice, Peter L. Munk, Javier Muñoz-Garcia, Marcia A. Munoz, Ioannis Ntanasis-Stathopoulos, Oumaima Omran, Sean Ong, Benjamin Ory, Penelope D. Ottewell, Hugue A. Ouellette, Hui Pang, K. Pantel, Alexander H.G. Paterson, Ana Patiño-García, Peter Peneder, Tanguy Perennec, Margherita Puppo, Neiroshan Rajarubendra, Srinivas Raman, M.E. Revheim, I. Richert, Günther Richter, René Rodríguez, Michael J. Rogers, Nadia Rucci, Pietro Ruggieri, Lubaid Saleh, Markus J. Seibel, Gene P. Siegal, B. Ewa Snaar-Jagalska, Sofia Sousa, Jeremy A. Squire, Arne Streitbuerger, Murali Sundaram, Stéphane Supiot, Julie Talbot, Matthias Tallegas, Marta Téllez-Gabriel, Evangelos Terpos, Pichaya Thanindratarn, Erik W. Thompson, Roberto Tirabosco, Franck Tirode, Eleni M. Tomazou, Marcus Tötzl, Bradley M. Turner, Martin Valentine, Manoj K. Valluru, Gualter Vaz, Franck Verrecchia, Ning Wang, Shi Wei, Fern Wesson, Steven L. Wood, Liangcheng Henry Xu, Yet Yen Yan, Lidan You, Xiang H. -F. Zhang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee46c4bf7e143bcb3da3205c20b89b28
https://doi.org/10.1016/b978-0-12-821666-8.01002-1