Mannan-MOG35-55 Reverses Experimental Autoimmune Encephalomyelitis, Inducing a Peripheral Type 2 Myeloid Response, Reducing CNS Inflammation, and Preserving Axons in Spinal Cord Lesions

Autor: Anastasia Dagkonaki, Maria Avloniti, Maria Evangelidou, Irini Papazian, Ioannis Kanistras, Vivian Tseveleki, Fotis Lampros, Theodore Tselios, Lise Torp Jensen, Wiebke Möbius, Torben Ruhwedel, Maria-Eleni Androutsou, John Matsoukas, Maria Anagnostouli, Hans Lassmann, Lesley Probert

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

CNS autoantigens conjugated to oxidized mannan (OM) induce antigen-specific T cell tolerance and protect mice against autoimmune encephalomyelitis (EAE). To investigate whether OM-peptides treat EAE initiated by human MHC class II molecules, we admin

Externí odkaz: https://doaj.org/article/01e6e4ce64414d3fbec5f23cf0834a95

Facile and Efficient Syntheses of a Series of N-Benzyl and N-Biphenylmethyl Substituted Imidazole Derivatives Based on (E)-Urocanic acid, as Angiotensin II AT1 Receptor Blockers

Autor: Theodore Tselios, Catherine Koukoulitsa, Demetrios Vlahakos, Panagiotis Plotas, Dimitra Kalavrizioti, Maria-Eleni Androutsou, Amalia Resvani, Konstantinos Kelaidonis, George Agelis, Thomas Mavromoustakos, John Matsoukas

Publikováno v: Molecules, Vol 18, Iss 7, Pp 7510-7532 (2013)

In the present work, a facile and efficient route for the synthesis of a series of N-substituted imidazole derivatives is described. Docking studies have revealed that N-substituted imidazole derivatives based on (E)-urocanic acid may be potential an

Externí odkaz: https://doaj.org/article/c3f9c354ea824649b5becf16b8c22cf5

Mannan-MOG35-55 Reverses Experimental Autoimmune Encephalomyelitis, Inducing a Peripheral Type 2 Myeloid Response, Reducing CNS Inflammation, and Preserving Axons in Spinal Cord Lesions

Autor: Maria Evangelidou, Vivian Tseveleki, Ioannis Kanistras, Fotis Lampros, Hans Lassmann, Anastasia Dagkonaki, Maria-Eleni Androutsou, Irini Papazian, Theodore Tselios, Torben Ruhwedel, Lise T. Jensen, Maria Anagnostouli, Maria Avloniti, Lesley Probert, John Matsoukas, Wiebke Möbius

Publikováno v: Frontiers in Immunology
Dagkonaki, A, Avloniti, M, Evangelidou, M, Papazian, I, Kanistras, I, Tseveleki, V, Lampros, F, Tselios, T, Jensen, L T, Möbius, W, Ruhwedel, T, Androutsou, M E, Matsoukas, J, Anagnostouli, M, Lassmann, H & Probert, L 2020, ' Mannan-MOG35-55 Reverses Experimental Autoimmune Encephalomyelitis, Inducing a Peripheral Type 2 Myeloid Response, Reducing CNS Inflammation, and Preserving Axons in Spinal Cord Lesions ', Frontiers in Immunology, vol. 11, 575451 . https://doi.org/10.3389/fimmu.2020.575451
Frontiers in Immunology, Vol 11 (2020)

CNS autoantigens conjugated to oxidized mannan (OM) induce antigen-specific T cell tolerance and protect mice against autoimmune encephalomyelitis (EAE). To investigate whether OM-peptides treat EAE initiated by human MHC class II molecules, we admin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb7385b0b831c52b951e62281ba380d
http://europepmc.org/articles/PMC7711156

Cyclic citrullinated MBP87–99 peptide stimulates T cell responses: Implications in triggering disease

Autor: George Deraos, Vasso Apostolopoulos, Theodore Tselios, Stephanie Day, Lily Stojanovska, John Matsoukas, Minos-Timotheos Matsoukas, Maria-Eleni Androutsou

Publikováno v: Bioorganic & Medicinal Chemistry. 25:528-538

Amino acid mutations to agonist peptide epitopes of myelin proteins have been used to modulate immune responses and experimental autoimmune encephalomyelitis (EAE, animal model of multiple sclerosis). Such amino acid alteration are termed, altered pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6086b561eeb2025d8349b32093c4f995
https://doi.org/10.1016/j.bmc.2016.11.029

Gonadotropin-Releasing Hormone and GnRH Receptor: Structure, Function and Drug Development

Autor: Theodore Tselios, Maria-Eleni Androutsou, Agathi Nteli, Haralambos Tzoupis

Publikováno v: Current medicinal chemistry. 27(36)

Background: Gonadotropin-Releasing Hormone (GnRH) is a key element in sexual maturation and regulation of the reproductive cycle in the human organism. GnRH interacts with the pituitary cells through the activation of the Gonadotropin Releasing Hormo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee311876f8b7d990363081997828735
https://pubmed.ncbi.nlm.nih.gov/31309882