Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Elene A Clemens"'
Publikováno v:
Vaccines, Vol 12, Iss 4, p 415 (2024)
A number of studies have demonstrated the role of sex in regulating immune responses to vaccination. However, these findings have been limited to adults for both human and animal models. As a result, our understanding of the impact of sex on vaccine
Externí odkaz:
https://doaj.org/article/15f1099d57074586b10a0d5bdffb237d
Autor:
Elene A. Clemens, Beth C. Holbrook, Brendan McNeilly, Masaru Kanekiyo, Barney S. Graham, Martha A. Alexander-Miller
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract The newborn immune system is characterized by diminished immune responses that leave infants vulnerable to virus-mediated disease and make vaccination more challenging. Optimal vaccination strategies for influenza A virus (IAV) in newborns s
Externí odkaz:
https://doaj.org/article/0195d32458f045e08656e0ff0104f0be
Publikováno v:
Viruses, Vol 13, Iss 7, p 1392 (2021)
The immune system of young infants is both quantitatively and qualitatively distinct from that of adults, with diminished responsiveness leaving these individuals vulnerable to infection. Because of this, young infants suffer increased morbidity and
Externí odkaz:
https://doaj.org/article/9428c0f289284eb5a240b16b227be717
Autor:
Elene A Clemens, Jonathan W. Yewdell, Martha A. Alexander-Miller, Barney S. Graham, Beth C. Holbrook, Masaru Kanekiyo
Publikováno v:
J Infect Dis
Eliciting broadly protective antibodies is a critical goal for the development of more effective vaccines against influenza. Optimizing protection is of particular importance in newborns, who are highly vulnerable to severe disease following infectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e7b600c27a5761811b1a7f8914bd72
https://europepmc.org/articles/PMC8280492/
https://europepmc.org/articles/PMC8280492/
Autor:
Matthew J. Jorgensen, Elene A Clemens, Jonathan W. Yewdell, Beth C. Holbrook, Martha A. Alexander-Miller, Davide Angeletti, Barney S. Graham, Masaru Kanekiyo
Publikováno v:
JCI insight. 5(5)
The specificity of antibodies (Abs) generated against influenza A virus (IAV) infection can significantly alter protection and viral clearance. At present, the impact of age upon this process is relatively unexplored. Here, we evaluated the Ab respon
Autor:
S. Bruce King, Elene A Clemens, Marlena M. Westcott, Beth C. Holbrook, Martha A. Alexander-Miller
Publikováno v:
Vaccine. 36:1174-1182
Inactivated influenza vaccines are not approved for use in infants less than 6 months of age due to poor immunogenicity in that population. While the live attenuated influenza vaccine has the potential to be more immunogenic, it is not an option for
Autor:
S. Bruce King, S. Tyler Aycock, Beth C. Holbrook, Emily Machiele, Mallinath B. Hadimani, Elene A Clemens, Matthew J. Jorgensen, Martha A. Alexander-Miller, Danielle Gries
Publikováno v:
Immunology. 153:357-367
Impaired immune responsiveness is a significant barrier to vaccination of neonates. By way of example, the low seroconversion observed following influenza vaccination has led to restriction of its use to infants over 6 months of age, leaving younger
Autor:
Elene A Clemens, Davide Angeletti, Beth C Holbrook, Scott Tyler Aycock, Jonathan W. Yewdell, Martha A Alexander-Miller
Publikováno v:
The Journal of Immunology. 202:74.13-74.13
Generation of effective antibody responses following virus infection is challenging in neonates as a result of impairments in the innate and adaptive immune systems that characterize early life. This leaves them particularly susceptible to severe dis