Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Elena de la Cuesta"'
Autor:
Juan F. González, María-Auxiliadora Dea-Ayuela, Lena Huck, José María Orduña, Francisco Bolás-Fernández, Elena de la Cuesta, Nazia Haseen, Ashraf Ali Mohammed, J. Carlos Menéndez
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 487 (2024)
We present a new category of quinoxaline di-N-oxides (QdNOs) containing amino acid side chains with dual antituberculosis and antileishmanial activity. These compounds were synthesized by combining a regioselective 2,5-piperazinedione opening and a B
Externí odkaz:
https://doaj.org/article/81f7d0e10c1b4f46b4287417861449ee
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 1772-1777 (2016)
A sequential three-component process is described, starting from 3-arylmethylene-2,5-piperazinediones and involving a one-pot sequence of reactions achieving regioselective opening of the 2,5-diketopiperazine ring and diastereoselective generation of
Externí odkaz:
https://doaj.org/article/c8261804429148f5ab4dce9783c499b9
Publikováno v:
ARKIVOC, Vol 2011, Iss 3, Pp 200-211 (2011)
Externí odkaz:
https://doaj.org/article/bfc86273c15240ba8a8d1340c434f2de
Publikováno v:
ARKIVOC, Vol 2005, Iss 9, Pp 30-38 (2005)
Externí odkaz:
https://doaj.org/article/66af4a0d7fba46e19d77e2e189d66707
Publikováno v:
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 1772-1777 (2016)
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 1772-1777 (2016)
A sequential three-component process is described, starting from 3-arylmethylene-2,5-piperazinediones and involving a one-pot sequence of reactions achieving regioselective opening of the 2,5-diketopiperazine ring and diastereoselective generation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998283277e44828d85f4da2ae094a81e
http://europepmc.org/articles/PMC4979736
http://europepmc.org/articles/PMC4979736
Publikováno v:
ARKIVOC, Vol 2011, Iss 3, Pp 200-211 (2011)
A multi-step synthetic strategy to obtain N-4-nitrophenyl-pyruvoyl-amino esters at a multi-gram scale has been developed. The subsequent domino reaction promoted by catalytic hydrogenation of the nitro group gave diaza-paracyclophane 3, 13 and 14. Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c295ec388b62ccaf28e74189946c88b
https://doi.org/10.3998/ark.5550190.0012.316
https://doi.org/10.3998/ark.5550190.0012.316
Publikováno v:
Tetrahedron. 66:8707-8713
Pyrazino[1,2- b ]isoquinoline-1,4-diones ( 3 ) having a bulky activating group at the N(2)-position were rearranged to tetramic acids with a benzo[ f ]indolizine skeleton ( 8 ) in the presence of K t BuO or LHMDS as bases. This rearrangement was dias
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd6ebd56eb8b28337a71e778088394f7
https://doi.org/10.1016/j.tet.2010.09.011
https://doi.org/10.1016/j.tet.2010.09.011
Publikováno v:
Tetrahedron. 66:646-652
The hypervalent iodine reagent PhI(OH)OTs (HTIB) promoted oxidative demethylation of 1,4-hydroquinone methyl ethers to give quinones in a quantitative conversion. The efficacy of this reaction, that has been applied to simple arene compounds and to h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f848ea002dae0782a33f9ec9056dfaf
https://doi.org/10.1016/j.tet.2009.11.070
https://doi.org/10.1016/j.tet.2009.11.070
Autor:
Elena de la Cuesta, Juan Francisco González, Irene Ortín, Cristina Manguan-García, Rosario Perona, Carmen Avendaño
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:8040-8047
The cytotoxicity showed by 1b, an interesting representant of the title compounds, for HT-29 human colon cancer cells (CI(50) value of 1.95 x 10(-7)M) has been related to the induced cell death at the G2 phase and not to DNA damage. This compound pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ea4e18ea324b53cadd00504af1e11a
https://doi.org/10.1016/j.bmc.2009.10.007
https://doi.org/10.1016/j.bmc.2009.10.007
Publikováno v:
Tetrahedron. 65:9944-9951
To avoid the epimerization of the C(11a)-stereocenter previously observed in 6,11a-cis-pyrazino[1,2-b]isoquinolin-1,4-diones, we present in this paper the C(3)-alkylation of 1-methoxy-pyrazino[1,2-b]isoquinolin-4-ones to obtain all-cis derivatives th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9281e2b8cfb3487fd9d0b9a5ad7eb20d
https://doi.org/10.1016/j.tet.2009.10.016
https://doi.org/10.1016/j.tet.2009.10.016