Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Elena Zelin"'
Publikováno v:
PLoS Biology, Vol 16, Iss 7, p e2005840 (2018)
Clustered, regularly interspaced, short palindromic repeat (CRISPR)-CRISPR-associated 9 (Cas9) genome editing is revolutionizing fundamental research and has great potential for the treatment of many diseases. While editing of immortalized cell lines
Externí odkaz:
https://doaj.org/article/c2e3474cd33b4e4b8a7eacf1fd692fe4
Autor:
Celeste Riepe, Elena Zelin, Phillip A. Frankino, Zuriah A. Meacham, Samantha G. Fernandez, Nicholas T. Ingolia, Jacob E. Corn
Publikováno v:
The FEBS Journal, 289 (11)
DNA damage activates a robust transcriptional stress response, but much less is known about how DNA damage impacts translation. The advent of genome editing with Cas9 has intensified interest in understanding cellular responses to DNA damage. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe61567d7d91d27c9cc2ab25771b6289
https://doi.org/10.1111/febs.16321
https://doi.org/10.1111/febs.16321
Autor:
Champak Chatterjee, Abhinav Dhall, Jacob E. Corn, Rachel E. Klevit, Elena Zelin, Mary Claire King, Mikaela D. Stewart, Esha Upadhyay, Tom Walsh
Publikováno v:
Proceedings of the National Academy of Sciences. 115:1316-1321
Missense mutations that disrupt the RING domain of the tumor suppressor gene BRCA1 lead to increased risk of breast and ovarian cancer. The BRCA1 RING domain is a ubiquitin ligase, whose structure and function rely critically on forming a heterodimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c283f34b68bbec999566e28262a2364a
https://doi.org/10.1073/pnas.1715467115
https://doi.org/10.1073/pnas.1715467115
Double Stranded DNA Breaks and Genome Editing Trigger Ribosome Remodeling and Translational Shutdown
Autor:
Elena Zelin, Nicholas T. Ingolia, Alexander Marson, Jr Liang, Jonathan T. Vu, Jacob E. Corn, C Riepe, Stacia K. Wyman, Phillip A. Frankino, David N. Nguyen, Zuriah A. Meacham
SummaryDNA damage activates a robust transcriptional stress response, but much less is known about how DNA impacts translation. The advent of genome editing via a Cas9-induced DNA double-strand break has intensified interest in understanding cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f549f80682a83164078ed3ed1630660
Publikováno v:
PLoS Biology, Vol 16, Iss 7, p e2005840 (2018)
PLoS biology, vol 16, iss 7
PLoS biology, vol 16, iss 7
Clustered, regularly interspaced, short palindromic repeat (CRISPR)–CRISPR-associated 9 (Cas9) genome editing is revolutionizing fundamental research and has great potential for the treatment of many diseases. While editing of immortalized cell lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650420afcb51b17167c1315991b9f825
http://europepmc.org/articles/PMC6049001?pdf=render
http://europepmc.org/articles/PMC6049001?pdf=render
CRISPR-Cas9 genome editing is revolutionizing fundamental research and has great potential for the treatment of many diseases. While editing of immortalized cell lines has become relatively easy, editing of therapeutically relevant primary cells and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90ad5a8b6e2f5140e2a84589e6b6a0ac
Autor:
Nicholas L. Bray, Katelynn R. Kazane, Stephen N. Floor, Jacob E. Corn, Christopher D. Richardson, Sharon J. Feng, Axel J. Schäfer, Elena Zelin
Publikováno v:
Nature genetics. 50(8)
CRISPR–Cas genome editing creates targeted DNA double-strand breaks (DSBs) that are processed by cellular repair pathways, including the incorporation of exogenous DNA via single-strand template repair (SSTR). To determine the genetic basis of SSTR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b62f9506cab75e0dc5da86ef59e458
https://pubmed.ncbi.nlm.nih.gov/30054595
https://pubmed.ncbi.nlm.nih.gov/30054595
Publikováno v:
Molecular Cell. 48(3):459-470
Cellular processes function through multi-step pathways that are reliant on the controlled association and disassociation of sequential protein complexes. While dynamic action is critical to propagate and terminate work, the mechanisms used to disass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940048223b00387525782181c969101f
Autor:
Brian C. Freeman, Michael J. Garabedian, Ellinor Oxelmark, Elena Zelin, Joyce I. Woo, Frank J. Echtenkamp, Brenda J. Andrews
Publikováno v:
Molecular Cell. 43(2):229-241
In parallel with evolutionary developments, the Hsp90 molecular chaperone system shifted from a simple prokaryotic factor into an expansive network that includes a variety of cochaperones. We have taken high-throughput genomic and proteomic approache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc30dee9902994039c53dd611ed92fc
Autor:
Scott K. Silverman, Elena Zelin
Publikováno v:
ChemBioChem. 8:1907-1911
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c86da91c56eabeba7ec7c25aa20e7c01
https://doi.org/10.1002/cbic.200700437
https://doi.org/10.1002/cbic.200700437