Impact of the Polymorphism of the PACRG and CD80 Genes on the Development of the Different Stages of Tuberculosis Infection

Autor: Elena Yu. Bragina, Nadezhda P. Babushkina, Anna F. Garaeva, Alexey A. Rudko, Dmitry Yu. Tsitrikov, Densema E. Gomboeva, Maxim B. Freidin

Publikováno v: Iranian Journal of Medical Sciences, Vol 44, Iss 3, Pp 236-244 (2019)

Background: Tuberculosis (TB) is one of the most significant health-care problems worldwide. The host’s genetics play an important role in the development of TB in humans. The disease progresses through several stages, each of which can be under th

Externí odkaz: https://doaj.org/article/92b5fb53294a44d6936210f0704b488e

GenCoNet – A Graph Database for the Analysis of Comorbidities by Gene Networks

Autor: Alban Shoshi, Vladimir A. Ivanisenko, Ralf Hofestädt, Alex Maier, Victor E. Dosenko, Marcel Friedrichs, Olga Zolotareva, Elena Yu. Bragina

Publikováno v: Journal of Integrative Bioinformatics, Vol 15, Iss 4, Pp 85-90 (2018)
Journal of Integrative Bioinformatics

The prevalence of comorbid diseases poses a major health issue for millions of people worldwide and an enormous socio-economic burden for society. The molecular mechanisms for the development of comorbidities need to be investigated. For this purpose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7cc9be4b3fbd40f4110ad41ebf4d26
https://doaj.org/article/1ae103c1dd7c4af7a28017c3c3f2a1a7

Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks

Autor: Inna N. Lavrik, Ralf Hofestaedt, Maxim B. Freidin, Olga Zolotareva, Victor E. Dosenko, I. A. Goncharova, Elena Yu. Bragina, Olga V. Saik, Evgeny I. Rogaev, Timofey V. Ivanisenko, P. S. Demenkov, Vladimir A. Ivanisenko

Publikováno v: BMC Medical Genomics, Vol 11, Iss S1, Pp 61-76 (2018)
BMC Medical Genomics

Background Hypertension and bronchial asthma are a major issue for people’s health. As of 2014, approximately one billion adults, or ~ 22% of the world population, have had hypertension. As of 2011, 235–330 million people globally have been affec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d094ed4273fa9c3cd791fd79e9184e2
http://link.springer.com/article/10.1186/s12920-018-0331-4

shRNA-Induced Knockdown of a Bioinformatically Predicted Target IL10 Influences Functional Parameters in Spontaneously Hypertensive Rats with Asthma

Autor: Roman Morhachov, Vasyl S. Nagibin, Vladimir A. Ivanisenko, Veronika L. Gurianova, Maxim B. Freidin, Tatiana Lapikova-Bryhinska, Oleksiy I. Boldyriev, Lesya V. Tumanovska, Borys Dons'koi, Ralf Hofestädt, Elena Yu. Bragina, Victor E. Dosenko, Tatiana Drevytska, Georgiy Portnichenko

Publikováno v: Journal of Integrative Bioinformatics, Vol 15, Iss 4, Pp 455-68 (2018)
Drevytska, T, Morhachov, R, Tumanovska, L, Portnichenko, G, Nagibin, V, Boldyriev, O, Lapikova-Bryhinska, T, Gurianova, V, Dons'koi, B, Freidin, M, Ivanisenko, V, Bragina, E Y, Hofestaedt, R & Dosenko, V 2018, ' shRNA-Induced Knockdown of a Bioinformatically Predicted Target IL10 Influences Functional Parameters in Spontaneously Hypertensive Rats with Asthma ', Journal of integrative bioinformatics, vol. 15, no. 4 . https://doi.org/10.1515/jib-2018-0053
Journal of Integrative Bioinformatics

One of the most common comorbid pathology is asthma and arterial hypertension. For experimental modeling of comorbidity we have used spontaneously hypertensive rats with ovalbumin (OVA)-induced asthma. Rats were randomly divided into three groups: co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa67f8b7c49f888d37029abd7d0532b2
https://doi.org/10.1515/jib-2018-0053

Differential genetic background of primary and secondary tuberculosis in Russians

Autor: A. A. Rudko, Maxim B. Freidin, Anna F. Garaeva, Nadezda P. Babushkina, Elena Yu. Bragina, I. A. Goncharova

Publikováno v: Meta Gene. 11:178-180

Tuberculosis is a global healthcare challenge. Host genetic factors were proven to modify risk of the disease. Genome-wide association studies revealed a number of loci associated with TB in different populations. However, no systematic analysis of g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c96b27f9cea7f24aa597d7d2f8aee02
https://doi.org/10.1016/j.mgene.2016.10.008