Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Elena Y. Komarova"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 3951 (2024)
The accumulation of misfolded and aggregated α-synuclein can trigger endoplasmic reticulum (ER) stress and the unfolded protein response (UPR), leading to apoptotic cell death in patients with Parkinson’s disease (PD). As the major ER chaperone, g
Externí odkaz:
https://doaj.org/article/6d9cd33c71a84b1cb472f516d02ba69c
Autor:
Elena Y. Komarova, Roman V. Suezov, Alina D. Nikotina, Nikolay D. Aksenov, Luiza A. Garaeva, Tatiana A. Shtam, Alexander V. Zhakhov, Marina G. Martynova, Olga A. Bystrova, Maria S. Istomina, Alexander M. Ischenko, Boris A. Margulis, Irina V. Guzhova
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract The release of Hsp70 chaperone from tumor cells is found to trigger the full-scale anti-cancer immune response. Such release and the proper immune reaction can be induced by the delivery of recombinant Hsp70 to a tumor and we sought to explo
Externí odkaz:
https://doaj.org/article/762a5bdc6a4f4b2b84b8badc8231ca47
Autor:
Alina D. Nikotina, Snezhana A. Vladimirova, Nadezhda E. Kokoreva, Elena Y. Komarova, Nikolay D. Aksenov, Sergey Efremov, Elizaveta Leonova, Rostislav Pavlov, Viktor G. Kartsev, Zhichao Zhang, Boris A. Margulis, Irina V. Guzhova
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 923 (2022)
Despite significant progress in the diagnosis and treatment of colorectal cancer, drug resistance continues to be a major limitation of therapy. In this regard, studies aimed at creating combination therapy are gaining popularity. One of the most pro
Externí odkaz:
https://doaj.org/article/95091978f5174c428b61b1cc9fcb38c8
Autor:
Vladimir F. Lazarev, Elizaveta A. Dutysheva, Elena Y. Komarova, Irina V. Guzhova, Boris A. Margulis
Publikováno v:
Data in Brief, Vol 20, Iss , Pp 899-902 (2018)
These data are related to our paper “GAPDH-targeted therapy – a new approach for secondary damage after traumatic brain injury on rats” (Lazarev et al., In press), in which we explore the role of exogenous GAPDH in traumatic brain injury-induce
Externí odkaz:
https://doaj.org/article/b0bd037f9222433c99c1fecfd96f024f
Autor:
Alina D. Nikotina, Snezhana A. Vladimirova, Elena Y. Komarova, Dmitry Alexeev, Sergey Efremov, Elizaveta Leonova, Rostislav Pavlov, Viktor G. Kartsev, Sergey G. Polonik, Boris A. Margulis, Irina V. Guzhova
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 6902 (2021)
Hyperglycemia may contribute to the progression of carcinomas by triggering epithelial-to-mesenchymal transition (EMT). Some proteostasis systems are involved in metastasis; in this paper, we sought to explore the mechanism of Hsp70 chaperone in EMT.
Externí odkaz:
https://doaj.org/article/3fcce8279a9c44c5aa680fb98dc45500
Autor:
Dmitry V. Sverchinsky, Alina D. Nikotina, Elena Y. Komarova, Elena R. Mikhaylova, Nikolay D. Aksenov, Vladimir F. Lazarev, Vladimir A. Mitkevich, Roman Suezov, Dmitry S. Druzhilovskiy, Vladimir V. Poroikov, Boris A. Margulis, Irina V. Guzhova
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 9, p 2519 (2018)
The Hsp70 chaperone binds and inhibits proteins implicated in apoptotic signaling including Caspase-3. Induction of apoptosis is an important mechanism of anti-cancer drugs, therefore Hsp70 can act as a protective system in tumor cells against therap
Externí odkaz:
https://doaj.org/article/e4f1fb4b0a4740738f556d7d8091a52e
Autor:
Alexander V. Zhakhov, N. D. Aksenov, Elena Y. Komarova, Maria S. Istomina, Alina D. Nikotina, M. G. Martynova, Irina V. Guzhova, Tatiana Shtam, Alexander M. Ischenko, Boris A. Margulis, O. A. Bystrova, Roman V. Suezov, Luiza Garaeva
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports
BackgroundThe release of Hsp70 chaperone from tumor cells is found to trigger the full-scale anti-cancer immune response. Such release and the proper immune reaction can be induced by the delivery of recombinant Hsp70 to a tumor and we sought to expl
Autor:
Viktor G Kartsev, Sergey G. Polonik, Elena Y. Komarova, Boris A. Margulis, Elizaveta Leonova, Dmitry G. Alexeev, Alina D. Nikotina, Sergey M. Efremov, Snezhana A Vladimirova, Irina V. Guzhova, Rostislav V. Pavlov
Publikováno v:
International Journal of Molecular Sciences; Volume 22; Issue 13; Pages: 6902
International Journal of Molecular Sciences, Vol 22, Iss 6902, p 6902 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 6902, p 6902 (2021)
International Journal of Molecular Sciences
Hyperglycemia may contribute to the progression of carcinomas by triggering epithelial-to-mesenchymal transition (EMT). Some proteostasis systems are involved in metastasis; in this paper, we sought to explore the mechanism of Hsp70 chaperone in EMT.
Autor:
Roman V. Suezov, Boris A. Margulis, Irina V. Guzhova, Alexander V. Zhakhov, N. D. Aksenov, Alexander M. Ischenko, Alina D. Nikotina, Larisa V Marchenko, Elena Y. Komarova
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 1
Volume 21
Issue 1
Cancer cells are known to contain high levels of the heat shock protein 70 kDa (Hsp70), which mediates increased cell proliferation, escape from programmed cell death, enhanced invasion, and metastasis. A part of Hsp70 molecules may release from canc
Autor:
Elena Y. Komarova, Irina V. Guzhova, Vladimir F. Lazarev, Elena R. Mikhaylova, Elizaveta A. Dutysheva, Boris A. Margulis
Publikováno v:
Biochemical and Biophysical Research Communications. 501:1003-1008
Massive neuronal death caused by a neurodegenerative pathology or damage due to ischaemia or traumatic brain injury leads to the appearance of cytosolic proteins in the extracellular space. We found that one of the most abundant cellular polypeptides