Hsp70-containing extracellular vesicles are capable of activating of adaptive immunity in models of mouse melanoma and colon carcinoma

Autor: Elena Y. Komarova, Roman V. Suezov, Alina D. Nikotina, Nikolay D. Aksenov, Luiza A. Garaeva, Tatiana A. Shtam, Alexander V. Zhakhov, Marina G. Martynova, Olga A. Bystrova, Maria S. Istomina, Alexander M. Ischenko, Boris A. Margulis, Irina V. Guzhova

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)

Abstract The release of Hsp70 chaperone from tumor cells is found to trigger the full-scale anti-cancer immune response. Such release and the proper immune reaction can be induced by the delivery of recombinant Hsp70 to a tumor and we sought to explo

Externí odkaz: https://doaj.org/article/762a5bdc6a4f4b2b84b8badc8231ca47

Hydrocortisone 21-hemisuccinate did not prevent exogenous GAPDH-induced apoptosis in human neuroblastoma cells

Autor: Vladimir F. Lazarev, Elizaveta A. Dutysheva, Elena Y. Komarova, Irina V. Guzhova, Boris A. Margulis

Publikováno v: Data in Brief, Vol 20, Iss , Pp 899-902 (2018)

These data are related to our paper “GAPDH-targeted therapy – a new approach for secondary damage after traumatic brain injury on rats” (Lazarev et al., In press), in which we explore the role of exogenous GAPDH in traumatic brain injury-induce

Externí odkaz: https://doaj.org/article/b0bd037f9222433c99c1fecfd96f024f

Prevention of High Glucose-Mediated EMT by Inhibition of Hsp70 Chaperone

Autor: Viktor G Kartsev, Sergey G. Polonik, Elena Y. Komarova, Boris A. Margulis, Elizaveta Leonova, Dmitry G. Alexeev, Alina D. Nikotina, Sergey M. Efremov, Snezhana A Vladimirova, Irina V. Guzhova, Rostislav V. Pavlov

Publikováno v: International Journal of Molecular Sciences; Volume 22; Issue 13; Pages: 6902
International Journal of Molecular Sciences, Vol 22, Iss 6902, p 6902 (2021)
International Journal of Molecular Sciences

Hyperglycemia may contribute to the progression of carcinomas by triggering epithelial-to-mesenchymal transition (EMT). Some proteostasis systems are involved in metastasis; in this paper, we sought to explore the mechanism of Hsp70 chaperone in EMT.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47980f1922b9b93d09ac680568b49d7

GAPDH-targeted therapy – A new approach for secondary damage after traumatic brain injury on rats

Autor: Elena Y. Komarova, Irina V. Guzhova, Vladimir F. Lazarev, Elena R. Mikhaylova, Elizaveta A. Dutysheva, Boris A. Margulis

Publikováno v: Biochemical and Biophysical Research Communications. 501:1003-1008

Massive neuronal death caused by a neurodegenerative pathology or damage due to ischaemia or traumatic brain injury leads to the appearance of cytosolic proteins in the extracellular space. We found that one of the most abundant cellular polypeptides

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23706a4c9216157b9205aad42a66a1c7
https://doi.org/10.1016/j.bbrc.2018.05.099

Etoposide-Induced Apoptosis in Cancer Cells Can Be Reinforced by an Uncoupled Link between Hsp70 and Caspase-3

Autor: Dmitry V Sverchinsky, Boris A. Margulis, Vladimir Poroikov, Elena R. Mikhaylova, Irina V. Guzhova, Dmitry S. Druzhilovskiy, Vladimir F. Lazarev, Alina D. Nikotina, N. D. Aksenov, Vladimir A. Mitkevich, Elena Y. Komarova, Roman V. Suezov

Publikováno v: International Journal of Molecular Sciences
Volume 19
Issue 9
International Journal of Molecular Sciences, Vol 19, Iss 9, p 2519 (2018)

The Hsp70 chaperone binds and inhibits proteins implicated in apoptotic signaling including Caspase-3. Induction of apoptosis is an important mechanism of anti-cancer drugs, therefore Hsp70 can act as a protective system in tumor cells against therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39814e2c2ca36ffda78dfa35560234b9